| Seahorse Operations Limited | Real estate | 2021 |
| Seahorse Property LLP | | 2020 |
| Seal NW Ltd | Administrative & support | 2023 |
| Seaside Bars Ltd | Hospitality | 2025 |
| Seaside Chippy Ltd | Hospitality | 2023 |
| Seaside E-Bikes Ltd | Wholesale & retail | 2025 |
| Seaside Fish & Chips Limited | Hospitality | 2012 |
| Seaside Group Plumbing & Heating Limited | Construction | 2024 |
| Seasiders Properties Limited | Real estate | 2026 |
| Seasonal Stock Ltd | Wholesale & retail | 2022 |
| Seasons 24 Guest House Limited | Hospitality | 2013 |
| Seatondale Auctions Limited | Wholesale & retail | 2025 |
| Seaworks Offshore Services Limited | Professional & scientific | 2008 |
| Sebastian Ziabka Limited | Information & communication | 2019 |
| Seca One Art Ltd | Arts & recreation | 2024 |
| Secret Scents Limited | Wholesale & retail | 2024 |
| Secure Perspective Limited | Information & communication | 2012 |
| SECURED24 Limited | Administrative & support | 2019 |
| Securetronics Ltd | Wholesale & retail | 2018 |
| Security Air Services Limited | Extraterritorial | 1992 |
| Securlec Limited | Construction | 1999 |
| Sedaco Limited | Information & communication | 2015 |
| Seedle Properties Limited | Real estate | 2026 |
| Seegan Properties Limited | Real estate | 2018 |
| Seeley Developments Limited | Real estate | 2024 |
| SEI Events Northwest Ltd | Administrative & support | 2025 |
| SEI Northwest Ltd | Construction | 2024 |
| Selbourne Mini Market Ltd | Wholesale & retail | 2022 |
| Select Audio Ltd | Wholesale & retail | 2019 |
| Select Floorcoverings Limited | Information & communication | 2004 |
| Select Joinery Ltd | Construction | 2017 |
| Select Properties Northwest Ltd | Real estate | 2020 |
| Select Sports Group Limited | Professional & scientific | 2016 |
| Selene Invest Limited | Information & communication | 2021 |
| Selene Investments Limited | Real estate | 2019 |
| Selenite Guest House Ltd | Hospitality | 2019 |
| Selitsany Ltd | Real estate | 2024 |
| Sell a Vend Holdings Limited | Financial services | 2024 |
| Sell a Vend LLP | | 2013 |
| Sell a Vend Trading Limited | Other services | 2024 |
| Sell Your House Today Limited | Real estate | 2005 |
| Sellertons Limited | Wholesale & retail | 2024 |
| Semesys Ltd | Administrative & support | 2018 |
| Semh Services Limited | Information & communication | 2016 |
| Semiotica Ltd | Information & communication | 2009 |
| Semoma Limited | Extraterritorial | 2022 |
| Semsys Ltd | Information & communication | 2012 |
| Senior Life Magazine Limited | Information & communication | 2020 |
| Seniors North West Limited | Hospitality | 2000 |
| Sensory Adventures Limited | Hospitality | 2026 |
| Sensus Properties Ltd | Hospitality | 2024 |
| Sentient Logic Limited | Information & communication | 2007 |
| Sentinel Information Technology Services Limited | Information & communication | 2013 |
| Septa Consulting Limited | Administrative & support | 2020 |
| Sequoia Strategy Advisors Limited | Professional & scientific | 2017 |
| Seraph Automotive Software Consultancy Ltd | Professional & scientific | 2018 |
| Sereneai Ltd | Information & communication | 2025 |
| Serenity Care Homes Group Ltd | Health & social care | 2024 |
| Serenity Techcode Ltd | Information & communication | 2025 |
| Seriva Ltd | Wholesale & retail | 2025 |
| Servit-Ak Limited | Information & communication | 2010 |
| Seta Estates Limited | Real estate | 2026 |
| Settled in Properties Limited | Real estate | 2025 |
| Seven of Nine Holdings Ltd | Real estate | 2023 |
| Seven V Limited | Professional & scientific | 2006 |
| Sevenoaks Court Management Company Limited | Households | 1972 |
| Sevindie Limited | Financial services | 2020 |
| Sewa Ventures Ltd | Wholesale & retail | 2025 |
| SG Business Finance Solutions Ltd | Information & communication | 2018 |
| SG Joinery & Building NW Ltd | Construction | 2022 |
| SG Leisure Ltd | Hospitality | 2025 |
| SG Moore Limited | Professional & scientific | 2022 |
| SG Oakwell Limited | Hospitality | 2025 |
| SG Shgf Ltd | Education | 2023 |
| SG78 Ltd | Extraterritorial | 2025 |
| Sgas Limited | Extraterritorial | 2004 |
| SGB Construction (Northwest) Limited | Construction | 2020 |
| SGR Delivers Ltd | Transport & logistics | 2026 |
| SGR TM Ltd | Construction | 2018 |
| SGS & SFR Limited | Professional & scientific | 2022 |
| SH Shinka Ltd | Hospitality | 2026 |
| SHABBY2CHIC Community Interest Company | Education | 2009 |
| Shabstermobiles Ltd | Wholesale & retail | 2018 |
| Shabzys Ltd | Hospitality | 2019 |
| Shadow Wraps NW Ltd | Wholesale & retail | 2022 |
| Shafaqat ALI Ltd | Wholesale & retail | 2024 |
| Shaktiscaffolding Limited | Construction | 2025 |
| Shampoodles Limited | Professional & scientific | 2006 |
| Shane Boswell Ltd | Administrative & support | 2020 |
| Shannon Educational Psychology Ltd | Education | 2014 |
| Shapla Spice (Fylde) Ltd | Hospitality | 2017 |
| Shapley Homes Limited | Construction | 2008 |
| Sharda Consulting Ltd | Professional & scientific | 2011 |
| Sharnsure Ltd | Information & communication | 2017 |
| Sharon Caro Limited | Health & social care | 2013 |
| Sharp Flint Productions Limited | Information & communication | 2025 |
| Sharp Industrial Services Ltd | Administrative & support | 2017 |
| Sharp Property Maintenance Ltd | Construction | 2025 |
| Sharp Removals Limited | Transport & logistics | 2020 |
| Sharp Scaffolding Ltd | Construction | 2020 |