| Sharp's Properties Limited | Real estate | 2022 |
| Sharpe Family Travel Ltd | Administrative & support | 2024 |
| Shaughnessy Consulting Limited | Professional & scientific | 2015 |
| Shaw IT Services Ltd | Information & communication | 2020 |
| Shawarma Trend Limited | Hospitality | 2025 |
| Shawries Ltd | Hospitality | 2021 |
| She's Nails Boutique Ltd | Other services | 2023 |
| SHE: Systems, Humans, Evolution Ltd | Information & communication | 2025 |
| Sheffield Electrical Access Limited | Construction | 2007 |
| Sheldon Enterprises Ltd | Manufacturing | 1996 |
| Shell City Studios Ltd | Information & communication | 2024 |
| Shell Creative Limited | Information & communication | 2005 |
| Shenanigans Holdings Ltd | Real estate | 2024 |
| Shenanigans Ltd | Hospitality | 2012 |
| Shenko Enterprise Ltd | Real estate | 2016 |
| Shenko Inspection Services Ltd | Mining & quarrying | 2018 |
| Shenko Property Group Ltd | Real estate | 2022 |
| Shenko Property Ltd | Real estate | 2019 |
| Sherbert Lemon (UK) Limited | Information & communication | 2014 |
| Sherborne Court Apartments Management Company Limited | Households | 2014 |
| Shergrim Properties Ltd | Wholesale & retail | 2025 |
| Sheshea Naturals Ltd | Wholesale & retail | 2019 |
| She’S Nails 68 Ltd | Other services | 2026 |
| Shickers Tavern Ltd | Hospitality | 2024 |
| Shift Men’S Hub Limited | Other services | 2025 |
| Shinfix Ltd | Information & communication | 2020 |
| Shippy Chippy Fish and Chip Company Limited | Hospitality | 2016 |
| Shire Mason Limited | Manufacturing | 2025 |
| Shirmazzy Ltd | Wholesale & retail | 2016 |
| Shocked Events Ltd | Hospitality | 2025 |
| Shoemarket Limited | Wholesale & retail | 1982 |
| Shomi Ventures Ltd | Wholesale & retail | 2025 |
| Shop Localy Food Store Floryy Ltd | Manufacturing | 2020 |
| Shopello Hub Limited | Wholesale & retail | 2025 |
| Shoreline Estates Ltd | Real estate | 2020 |
| Shoretech Ltd | Professional & scientific | 2018 |
| Short Circuit Electrical NW Ltd | Construction | 2024 |
| SHOW2GO Events Ltd | Administrative & support | 2026 |
| Showseats Limited | Wholesale & retail | 2012 |
| Shray Foods Limited | Hospitality | 2023 |
| Shray Hotel Limited | Hospitality | 2025 |
| Shrewd-Move Ltd | Real estate | 2025 |
| SHS Fencing Limited | Construction | 2018 |
| SHS Fencing Supplies (North West) Ltd | Wholesale & retail | 2023 |
| Shundraw Limited | Real estate | 2020 |
| Shurmzzz Supplies Ltd | Wholesale & retail | 2023 |
| Shuttleworth Solutions Limited | Health & social care | 2021 |
| SIA PVT Ltd | Wholesale & retail | 2015 |
| SIA Trading Ltd | Wholesale & retail | 2019 |
| Siam Barber Ltd | Other services | 2026 |
| Siam Orca Asia (UK) Ltd | Mining & quarrying | 2025 |
| Sicily Food and Wine Ltd | Hospitality | 2018 |
| Sico-Developments Ltd | Wholesale & retail | 2014 |
| Sidato Ltd | Wholesale & retail | 2012 |
| Sidechain Consulting Ltd | Administrative & support | 2015 |
| Sidsshop.Com Ltd | Wholesale & retail | 2022 |
| Sigma Consultancy Solutions Limited | Professional & scientific | 2016 |
| Sigma Fabrics Ltd | Wholesale & retail | 2010 |
| Sigma Joinery Ltd | Construction | 2020 |
| Signature Apartments Ltd | Real estate | 2022 |
| Signature Collection Publishing Limited | Information & communication | 2025 |
| Signature Homes (Fleetwood) Ltd | Construction | 2020 |
| Signature Linen Limited | Other services | 2024 |
| Signature Property Lettings Ltd | Real estate | 2013 |
| Silkmill Mansion Limited | Construction | 2009 |
| Silly's Ices Ltd | Manufacturing | 2025 |
| Silvacreate Digital Agency Ltd | Information & communication | 2021 |
| Silvadynamics Limited | Information & communication | 2016 |
| Silver Lining Assets Ltd | Real estate | 2021 |
| Silver Links Property Management Limited | Real estate | 2026 |
| Silver Software Consultancy Ltd | Information & communication | 2021 |
| Silver Yacht Limited | Extraterritorial | 2015 |
| Silverbelly Western Ltd | Wholesale & retail | 2025 |
| Silverburn Services Limited | Households | 1970 |
| Silvercloud Properties Limited | Administrative & support | 2011 |
| Silverfish & Chips Ltd | Hospitality | 2023 |
| Silverstar Aviation Limited | Transport & logistics | 2003 |
| Simdav Holdings Limited | Administrative & support | 2024 |
| Simon Burgess Ltd | Information & communication | 2019 |
| Simon Hall DBA Limited | Information & communication | 2013 |
| Simpkin Consulting Limited | Information & communication | 2019 |
| Simple Property Investing Ltd | Administrative & support | 2020 |
| Simple Solutions Blackpool Ltd | Construction | 2024 |
| Simple Touches Care Ltd | Health & social care | 2023 |
| Simply Haven Limited | Construction | 2021 |
| Simply Native Limited | Manufacturing | 2018 |
| Simply Natural Health and Beauty 2011 Limited | Other services | 2011 |
| Simply Stunning Styling Ltd | Real estate | 2024 |
| Simply-City Ltd | Information & communication | 2020 |
| Simpson's Beverage Supply Company Limited | Manufacturing | 1948 |
| Simpsons Holdings Limited | Financial services | 2017 |
| Simtech Golf Limited | Wholesale & retail | 2025 |
| Sine EAR Care Ltd | Health & social care | 2021 |
| Singh Properties U.K Limited | Real estate | 2025 |
| Singleton & Smart (Holdings) Limited | Construction | 1973 |
| Singleton & Smart Construction Ltd | Construction | 2022 |
| Singleton & Smart Limited | Construction | 1984 |
| Singleton Hall Management Company Limited | Households | 2006 |
| Sion Mills Contractors Limited | Wholesale & retail | 2025 |
| Sionmills Ltd | Wholesale & retail | 2025 |