| Sands Leisure (Blackpool) Ltd | Hospitality | 2010 |
| Sands Property (North West) Limited | Construction | 2025 |
| Sandtsercurity Ltd | Financial services | 2025 |
| Sandwich Co. Manufacturing Ltd | Wholesale & retail | 2025 |
| Sangreal Rings Ltd | Wholesale & retail | 2023 |
| Saniplex Ltd | Water & waste | 2021 |
| Sanjeevbp Limited | Hospitality | 2022 |
| Sanjefe Consultancy Ltd | Information & communication | 2014 |
| Sanplex International Ltd | Construction | 2018 |
| Sansberg Limited | Manufacturing | 2013 |
| Santerem Limited | Professional & scientific | 2003 |
| Santy Correa Properties Limited | Real estate | 2024 |
| Saoko Cocktail Club Limited | Hospitality | 2023 |
| Sapientia Engineering Ltd | Professional & scientific | 2019 |
| Sapphire Beauty Ltd | Other services | 2017 |
| Sapphire Mortgage & Protection Solutions Ltd | Financial services | 2015 |
| Sarah Bentley Optometry Ltd | Health & social care | 2015 |
| Sarah Jane Nielsen Ltd | Construction | 2003 |
| Sarah Lundy Marketing Limited | Professional & scientific | 2026 |
| Sarazen Limited | Professional & scientific | 2004 |
| Sargent Fitness Limited | Arts & recreation | 2018 |
| Sargesons Plumbers Merchants Limited | Wholesale & retail | 2011 |
| Sars Infoservices Ltd | Information & communication | 2018 |
| Sartaj Builders Ltd | Construction | 2026 |
| Sascouk Estate Agency Limited | Real estate | 2025 |
| Sascouk Limited | Households | 2018 |
| Sassthetics Training Academy Limited | Education | 2025 |
| Saturn Blue Limited | Administrative & support | 2025 |
| Savayon IT Consultancy and Training Ltd | Information & communication | 2017 |
| Savi Fella Ltd | Wholesale & retail | 2022 |
| Saxually Active Limited | Arts & recreation | 2015 |
| Saxually Active Records Ltd | Arts & recreation | 2020 |
| SAY IT With a Sweetie Ltd | Wholesale & retail | 2009 |
| SAY Less Clothing UK Ltd | Wholesale & retail | 2025 |
| SB Cowley Ltd | Wholesale & retail | 2024 |
| SB Gibson Homes Ltd | Real estate | 2025 |
| SB Gibson Properties Ltd | Real estate | 2018 |
| SB Inspection & Expediting Services Ltd | Professional & scientific | 2006 |
| SB Logistics and Training Ltd | Transport & logistics | 2025 |
| SB Shortridge Ltd | Other services | 2024 |
| SB Waste Management Limited | Water & waste | 2006 |
| SBD IT Consulting Limited | Other services | 2013 |
| SBG Contracts Limited | Construction | 2008 |
| SBL Careservices (UK) Ltd | Health & social care | 2018 |
| SBL Contractors Ltd | Construction | 2023 |
| SBL Holdings (NW) Ltd | Financial services | 2026 |
| Sbma Ltd | Professional & scientific | 2019 |
| SBR Foxhills Limited | Agriculture & fishing | 2017 |
| SBS Financial Solutions Ltd | Financial services | 2024 |
| SBS Portal Ltd | Financial services | 2021 |
| Scalesceugh Management Company Ltd | Households | 2018 |
| Scanlite Visual Communications Limited | Manufacturing | 1996 |
| Scantarni Properties Limited | Real estate | 2002 |
| Scarlett Couriers Limited | Transport & logistics | 2010 |
| Scatola Limited | Other services | 2018 |
| SCD Promotions (Properties) Limited | Real estate | 2020 |
| SCD Promotions Limited | Professional & scientific | 2012 |
| Scenario Housing C.I.C. | Real estate | 2022 |
| Scenicdesigner Ltd | Professional & scientific | 2023 |
| SCF Consulting Limited | Information & communication | 2008 |
| Schaefer Property Invest Ltd | Real estate | 2017 |
| Schiltrom Limited | Professional & scientific | 2004 |
| Schneider Property (Management) Ltd | Households | 2021 |
| Schofields Electrical Services (NW) Ltd | Construction | 2018 |
| Scholars Court (ST Annes) Limited | Households | 2001 |
| School Community Lettings Ltd | Arts & recreation | 2020 |
| Schreiber Rail Ltd | Construction | 2016 |
| Schur Thing Limited | Administrative & support | 2025 |
| SCJ Haines Limited | Financial services | 2023 |
| Sclyne Civils Ltd | Construction | 2025 |
| SCM Financial Planning Ltd | Professional & scientific | 2024 |
| Scoops Ice Cream Ltd | Hospitality | 2020 |
| Scope Construction Services Ltd | Construction | 2020 |
| Score by Goldstar Limited | Arts & recreation | 2024 |
| Scotish Law and Lawyers Limited | Professional & scientific | 2024 |
| Scott Elliott Limited | Administrative & support | 2003 |
| Scottlarock Ltd | Wholesale & retail | 2025 |
| Scratch Doctor Limited | Wholesale & retail | 2010 |
| Scream Management Limited | Administrative & support | 1998 |
| Scream Theatre Schools LLP | | 2018 |
| Screenco Ltd | Information & communication | 2020 |
| Scrivens Holdings Limited | Financial services | 2022 |
| Scrivens Recycling Limited | Water & waste | 2021 |
| Scrumsoft Limited | Information & communication | 2017 |
| Scubaco Limited | Arts & recreation | 2004 |
| SD Football Club Community Interest Company | Education | 2023 |
| SDG Light Limited | Information & communication | 2011 |
| SDH Drylining Ltd | Construction | 2022 |
| SE Blake Consulting Ltd | Information & communication | 2016 |
| SE Creations Limited | Manufacturing | 2025 |
| Sea Breeze Apartments Management Limited | Households | 2012 |
| Sea Cote Ltd | Hospitality | 2026 |
| Sea Glass Marketing Ltd | Professional & scientific | 2024 |
| Sea View Fish and Chips Limited | Hospitality | 2024 |
| Seabreeze Lodge Hotel Ltd | Hospitality | 2026 |
| Seadragon Software Limited | Information & communication | 2022 |
| Seafarers' Christian Friend Society | Health & social care | 1943 |
| Seafield House Management Limited | Households | 2009 |
| Seafront Collection Ltd | Hospitality | 2019 |
| Seagypsyness Limited | Extraterritorial | 2014 |