| Ryelands Services Ltd | Construction | 2025 |
| Ryse Energy (UK) Limited | Construction | 2005 |
| Ryta Consulting Ltd | Information & communication | 2019 |
| S & C Housing Ltd | Real estate | 2018 |
| S & D Spinks Limited | Other services | 2012 |
| S & J Clarkson Properties Ltd | Real estate | 2025 |
| S & K PUB Co Ltd | Hospitality | 2013 |
| S & S Bars Management Ltd | Hospitality | 2019 |
| S & S Electrical Engineering Ltd | Construction | 2014 |
| S & S Timber Supplies Limited | Manufacturing | 1984 |
| S & T Shop Fittings Limited | Real estate | 2012 |
| S and L TM Ltd | Administrative & support | 2017 |
| S G (2025) Limited | Real estate | 2025 |
| S G Battersby Limited | Wholesale & retail | 2014 |
| S G Wilson & SON (Builders) Ltd | Construction | 2003 |
| S J Hamer Holdings Ltd | Financial services | 2025 |
| S L Metalworkers Limited | Manufacturing | 2011 |
| S Mason UK Limited | Information & communication | 2010 |
| S Mccabe Limited | Construction | 2017 |
| S O Groundworks Ltd | Construction | 2025 |
| S P Safety Decking Limited | Construction | 2017 |
| S R I.T. Consultancy Limited | Professional & scientific | 2007 |
| S Richardson Installation Ltd | Manufacturing | 2023 |
| S Royle Roofing and SON Limited | Construction | 2020 |
| S Taylor Consulting Limited | Other services | 2013 |
| S Taylor Joinery Ltd | Manufacturing | 2022 |
| S Thornton Property Limited | Real estate | 2024 |
| S&B Electrical Contractors NW Ltd | Construction | 2021 |
| S&B Maintenance Solutions Limited | Construction | 2026 |
| S&B Property Lettings Ltd | Real estate | 2023 |
| S&D Blackpool Ltd | Hospitality | 2025 |
| S&L North Notts Ltd | Real estate | 2025 |
| S&R Plastering Ltd | Construction | 2025 |
| S&S Catering NW Ltd | Hospitality | 2026 |
| S&Z Group Holding Ltd | Other services | 2024 |
| S. Crossbones Company Limited | Wholesale & retail | 2003 |
| S. D. B. Fine Jewellers Ltd | Wholesale & retail | 2003 |
| S.A.Resources Limited | Health & social care | 2009 |
| S.B. NDT Limited | Construction | 2014 |
| S.Campbell & Sons Ltd | Transport & logistics | 2016 |
| S.E.C.T.O.R 01 Ltd | Arts & recreation | 2025 |
| S.J. Beard Limited | Health & social care | 2026 |
| S.J.Harper Ltd | Real estate | 2020 |
| S.N. Khatun Ltd | Hospitality | 2023 |
| S.P Transport (Preston) Limited | Transport & logistics | 2006 |
| S.P.T. NW Limited | Administrative & support | 2026 |
| S.R. Hill Electrical Limited | Construction | 1996 |
| S.W. Property Investments North West Limited | Real estate | 2001 |
| S.Windsor & Sons Ltd | Health & social care | 2024 |
| SA Holidays Limited | Hospitality | 2024 |
| SA Security Ltd | Administrative & support | 2021 |
| Sabai in Thai Massage Ltd | Other services | 2026 |
| Saber Toumi Ltd | Wholesale & retail | 2021 |
| Sabina Holdings Ltd | Real estate | 2018 |
| SAC Electrical Installations Ltd | Construction | 2025 |
| Safdar Munir Ltd | Wholesale & retail | 2024 |
| Safe and Sound North West Limited | Transport & logistics | 2025 |
| Safe and Sound SW Limited | Health & social care | 2026 |
| Safestart School Ltd | Education | 2022 |
| Saff Unit Ltd | Hospitality | 2026 |
| Saffir Limited | Hospitality | 2023 |
| Safo-Global Ltd | Wholesale & retail | 2020 |
| SAG Validation Consultancy Ltd | Administrative & support | 2012 |
| SAI Innovative Solutions Ltd | Information & communication | 2010 |
| Sailmed Marine Ltd | Arts & recreation | 2025 |
| Saint.T Ltd | Information & communication | 2022 |
| Saintfield Properties Ltd | Wholesale & retail | 2025 |
| Sakhawat Prime Technologies Limited | Wholesale & retail | 2026 |
| Saliza Healthcare Private Limited | Professional & scientific | 2018 |
| Salon 142 Limited | Other services | 1999 |
| Salt & Vinegar Fish & Chips Ltd | Hospitality | 2023 |
| Salt & Vinegar Fisheries Ltd | Hospitality | 2025 |
| Salud Tapas Kirkham Ltd | Hospitality | 2019 |
| Salute Yachting Limited | Extraterritorial | 2024 |
| SAM & Co (Blackpool) Ltd | Hospitality | 2019 |
| SAM Benson Ltd | Transport & logistics | 2025 |
| Sam's Chippy Limited | Hospitality | 2022 |
| Sam's Place NW Ltd | Health & social care | 2006 |
| Samarie Ventures Ltd | Wholesale & retail | 2023 |
| Sambabamba Ltd | Professional & scientific | 2007 |
| Samir & Sons Ltd | Wholesale & retail | 2021 |
| Sammy Electrical Installation Limited | Construction | 2018 |
| Samson International Ltd | Information & communication | 2023 |
| Samweb (UK) Ltd | Professional & scientific | 2013 |
| Samy&Sofia Sushi Limited | Hospitality | 2024 |
| SAN Carlos Holding Ltd | Real estate | 2026 |
| Sand Hurst Court Management Limited | Households | 1974 |
| Sandalwood Medical Limited | Administrative & support | 2013 |
| Sandath Management Limited | Hospitality | 1993 |
| Sanderling Close Property Management Limited | Households | 1996 |
| Sanderson Creative Productions Ltd | Information & communication | 2025 |
| Sandersons (N.W.) Ltd | Construction | 2002 |
| Sandgrown Holdings Ltd. | Financial services | 2018 |
| Sandgrown Leisure Ltd | Hospitality | 2018 |
| Sandgrown Limited | Real estate | 2014 |
| Sandhurstfilms Ltd | Information & communication | 2022 |
| Sandicroft 193 Limited | Professional & scientific | 2003 |
| Sandras-Online Limited | Wholesale & retail | 2021 |
| Sands (Cockerham) Ltd | Hospitality | 2021 |
| Sands Blackpool Property Ltd | Real estate | 2018 |