| DM Joinery and Building Limited | Construction | 2018 |
| Dmml Properties Limited | Real estate | 2018 |
| DMS Telecommunications Limited | Information & communication | 2009 |
| DNT Online Ltd | Wholesale & retail | 2024 |
| Dodecahedron Digital Ltd | Wholesale & retail | 2022 |
| Dog Wash (NW) Ltd | Other services | 2021 |
| Dogstar Consulting Ltd | Information & communication | 2026 |
| Donnelly Eco GAS Services Limited | Construction | 2013 |
| Donnelly Property Services Ltd | Real estate | 2024 |
| Don’T Panic Event Hire Ltd | Other services | 2020 |
| Don’T Panic Events Ltd | Other services | 2019 |
| Door Life Ltd | Wholesale & retail | 2026 |
| Doorstore (Wirral) Holding Limited | Financial services | 2024 |
| Doorstore (Wirral) Limited | Wholesale & retail | 1993 |
| Doorstore (Wirral) Property Limited | Real estate | 2024 |
| Dope Crusts Ltd | Hospitality | 2024 |
| DOT Art Limited | Arts & recreation | 2006 |
| DOT Art Services CIC | Arts & recreation | 2009 |
| DOT Art Training Ltd | Education | 2016 |
| Double Lucky House 888 Ltd | Hospitality | 2025 |
| Down to Earth Electrical Services Ltd | Construction | 2019 |
| Downey Structural Engineering Ltd | Professional & scientific | 2026 |
| Downing Close Flats Management Limited | Households | 1975 |
| Dowsett Electrical Limited | Construction | 2011 |
| Dowsett RAE Limited | Construction | 2010 |
| DPB Metals Ltd | Construction | 2026 |
| DR AMY Law Aesthetic Training Limited | Health & social care | 2024 |
| DR AMY Law Limited | Health & social care | 2021 |
| DR G Aesthetics Ltd | Other services | 2025 |
| DR Genevieve Limited | Health & social care | 2020 |
| DR Louise MAY Limited | Administrative & support | 2013 |
| DR Paul Holland Ltd | Health & social care | 2025 |
| DR. Eftekhari Ltd | Health & social care | 2011 |
| DRA Consultants Limited | Professional & scientific | 2015 |
| Dragon Maps Ltd | Information & communication | 2021 |
| Draki Limited | Administrative & support | 2014 |
| Dream Squad Ltd | Other services | 2018 |
| Drip Fashion Limited | Wholesale & retail | 2026 |
| Drip IT Limited | Other services | 2025 |
| Drip Limited | Wholesale & retail | 2022 |
| Drip Mode Ltd | Wholesale & retail | 2026 |
| Drivealong Ltd | Manufacturing | 2025 |
| Drivehub (NW) Limited | Wholesale & retail | 2025 |
| Drmcnrentals Ltd | Households | 2025 |
| Dromond Ltd | Professional & scientific | 2021 |
| Dropbox Green Energy Solutions (Global) Ltd | Professional & scientific | 2023 |
| DRP Super Sales Ltd | Financial services | 2019 |
| DRS Innovation Ltd. | Professional & scientific | 2014 |
| DRY Golf Limited | Arts & recreation | 2023 |
| Dsolomon Ltd | Information & communication | 2015 |
| Dt&G(Services) Ltd | Manufacturing | 2012 |
| Duart Group Ltd | Financial services | 2025 |
| Duckandgo Ltd | Construction | 2025 |
| Duckworks Ltd | Real estate | 2024 |
| DUN COW Leisure Limited | Hospitality | 2019 |
| Durst Financial Management Ltd | Professional & scientific | 2026 |
| Dusty Productions Ltd | Arts & recreation | 2024 |
| Dwight Turner Counselling Limited | Other services | 2007 |
| Dybur Property Limited | Professional & scientific | 2017 |
| Dylni Limited | Real estate | 1980 |
| Dymazoo Ltd | Information & communication | 2016 |
| E B Lyle Ltd | Wholesale & retail | 2025 |
| E&S Transport Ltd | Transport & logistics | 2019 |
| E. Reynolds (Timber) Ltd. | Manufacturing | 2009 |
| E.M.R Contracts Ltd. | Administrative & support | 2019 |
| Eagle Moon Ltd | Real estate | 2014 |
| Eamonn T Cookson & Company Limited | Professional & scientific | 2002 |
| Earth Flowers & Floral Academy Ltd | Wholesale & retail | 2024 |
| Earth Management Services Ltd | Water & waste | 2026 |
| Easi Rental Limited | Extraterritorial | 2007 |
| Eastham Aluminium Limited | Construction | 2016 |
| Eastham Woods Boarding Cattery Limited | Other services | 2012 |
| Echo Travel Limited | Transport & logistics | 2026 |
| Echosystems Technology Ltd | Information & communication | 2025 |
| Eco Homes Wirral Ltd | Construction | 2020 |
| Eco Travel Pet Taxi Ltd | Transport & logistics | 2025 |
| Ecoway Enterprises Limited | Water & waste | 2010 |
| Eden Rainsford Retail Partnerships Limited | Wholesale & retail | 2019 |
| Edge & SON Limited | Hospitality | 2017 |
| Edge Performance Limited | Other services | 2016 |
| Edible Cocktail Toppers Ltd | Wholesale & retail | 2019 |
| Edley Properties Ltd | Real estate | 2026 |
| Eesb Engineering Limited | Wholesale & retail | 2005 |
| Egerton Property Holdings Ltd | Real estate | 2017 |
| Egerton Park 5052 Ltd | Households | 1982 |
| Egerton Park Residents Limited | Households | 2005 |
| Egsm Associates Ltd | Professional & scientific | 2023 |
| Eight Star Food Limited | Other services | 2018 |
| EK Akaal Ltd | Transport & logistics | 2025 |
| ELC Wirral East Limited | Education | 2025 |
| Electro Vapors Ltd | Administrative & support | 2021 |
| Electromec Engineering Ltd | Other services | 2018 |
| Elegantly Chauffeured Limited | Transport & logistics | 2026 |
| Elektronix Ltd | Administrative & support | 2017 |
| Elephant Pumps Ltd | Extraterritorial | 2015 |
| Elevate Women’S Wellness Ltd | Professional & scientific | 2026 |
| Elif Aligul Ltd | Hospitality | 2024 |
| Elinas Impo-Expo Limited | Wholesale & retail | 2010 |
| Elite Boards Limited | Manufacturing | 2008 |
| Elite Building Services NW Ltd | Construction | 2024 |