| Danielle @ Borough Barbers Limited | Other services | 2019 |
| Danne Services Limited | Construction | 2025 |
| Danni Vanman Limited | Transport & logistics | 2024 |
| Dan’S Car Hospital Limited | Wholesale & retail | 2025 |
| Dargo Property Solutions Limited | Administrative & support | 2017 |
| Darin Barber Birkenhead Ltd | Other services | 2024 |
| Dark Phoenix Customs Ltd | Wholesale & retail | 2022 |
| Dark Reign Productions Limited | Arts & recreation | 2023 |
| Darts HQ Ltd | Wholesale & retail | 2025 |
| DAS Assets Limited | Real estate | 2020 |
| Data Monarque Ltd | Information & communication | 2026 |
| Data Zone London Ltd | Information & communication | 2023 |
| Datumo Ltd | Information & communication | 2013 |
| Dave Arch Products Limited | Professional & scientific | 2015 |
| Dave Bell Maths Tuition Ltd | Education | 2022 |
| Dave Ellis Quality Consultancy Limited | Information & communication | 1998 |
| Davhall Limited | Wholesale & retail | 2025 |
| David Bellis Consulting Surveyors Limited | Other services | 2004 |
| David Hayhurst Consultant Limited | Professional & scientific | 2020 |
| David Williams Marble and Granite Limited | Manufacturing | 1999 |
| Davida Engineering Limited | Manufacturing | 2019 |
| Davies Estate Management Company Limited | Real estate | 2009 |
| Davies Hospitality Wirral Ltd | Hospitality | 2024 |
| Davison Flynn Duke Solicitors LLP | | 2018 |
| Day & Night Events Ltd | Hospitality | 2026 |
| DB Properties (Southport) Ltd | Real estate | 2023 |
| DB Shiny Limited | Administrative & support | 2026 |
| DBE Sales & Service Limited | Other services | 1959 |
| DBS Liverpool Ltd | Hospitality | 2025 |
| DC Aviation Ltd | Other services | 2024 |
| DC Brickwork (NW) Limited | Construction | 2019 |
| DCT Removals Ltd | Transport & logistics | 2025 |
| Dealbern Marketing Ltd | Wholesale & retail | 2022 |
| Dean Timson Pipefitters Limited | Construction | 2012 |
| Debbie'Z Diamond'Z Ltd | Arts & recreation | 2025 |
| Debra Mccool Ltd | Other services | 2023 |
| DEC Properties NW Ltd | Real estate | 2025 |
| Decks and Dreams Ltd | Administrative & support | 2025 |
| Dee's Ginger Ltd | Wholesale & retail | 2023 |
| Deep Blue Sapphire Limited | Professional & scientific | 2015 |
| Deep Green Digital Ltd | Professional & scientific | 1994 |
| Deep Green Investments Ltd | Real estate | 2024 |
| Deeside Developments Limited | Construction | 2014 |
| Deeside Motor Centre Limited | Wholesale & retail | 2002 |
| Definite Talent Ltd | Professional & scientific | 2021 |
| Delicioso Noodle Bar Limited | Hospitality | 2022 |
| Delight Foodz UK Ltd | Hospitality | 2023 |
| Deliver Media Limited | Professional & scientific | 2012 |
| Delivery Right Couriers Ltd | Transport & logistics | 2022 |
| Deltatype Limited | Information & communication | 1986 |
| Delvemont Ltd | Information & communication | 2021 |
| Denbridge Marine Limited | Administrative & support | 2003 |
| Denebola Limited | Professional & scientific | 2002 |
| Denis Oakley & Co Limited | Professional & scientific | 2019 |
| Dependable Concrete (North West) Limited | Manufacturing | 2013 |
| Deralam Laminates Limited | Administrative & support | 1983 |
| Dermaessence Solutions Ltd | Other services | 2023 |
| Deserted Island Ltd Limited | Hospitality | 2025 |
| Deshi Spice Wirral Ltd | Hospitality | 2025 |
| Design My Stairs Ltd | Construction | 2019 |
| Designer Greetings UK Ltd | Manufacturing | 2025 |
| Desres Investments Ltd | Real estate | 2017 |
| Deva Electronic Controls Limited | Manufacturing | 1985 |
| Deva Office Automation Limited | | 1989 |
| Deva Resins Ltd | Construction | 2007 |
| Deva Roofing Ltd | Construction | 2018 |
| Devbros Consultancy Ltd | Information & communication | 2015 |
| Devicemark Limited | Health & social care | 2006 |
| Devon Holistic Neurodiversity Ltd | Health & social care | 2024 |
| DEX Digital Ltd | Information & communication | 2022 |
| DF Studios Limited | Professional & scientific | 2021 |
| DFI Services Ltd | Wholesale & retail | 2026 |
| DFM 11 Limited | Professional & scientific | 2011 |
| DGH Property Management Limited | Real estate | 2012 |
| Diamond Drainage NW Ltd | Construction | 2025 |
| Diamond Education Hub Limited | Education | 2017 |
| Diamond Precision Engineering (Wirral) Limited | Manufacturing | 2002 |
| Diegolinokcl Limited | Real estate | 2021 |
| Difficult Done Consulting Limited | Information & communication | 2024 |
| Digikape Ltd | Information & communication | 2022 |
| Digital Black Security Limited | Construction | 2014 |
| Digitel Europe Limited | Information & communication | 1992 |
| Diglo Global Ltd | Wholesale & retail | 2025 |
| Dilivad Limited | Transport & logistics | 2025 |
| Dilivah Ltd | Administrative & support | 2026 |
| Dillon Engineering Limited | Administrative & support | 1996 |
| Dingwall Media Limited | Information & communication | 2024 |
| Dinos Pizzeria Ltd | Hospitality | 2026 |
| Diponio Developments Ltd | Construction | 2024 |
| Direct Alarm Systems Limited | Manufacturing | 2003 |
| Discount Carpet Centre (New Ferry) Limited | Wholesale & retail | 2003 |
| Discovery Geological Limited | Mining & quarrying | 2018 |
| DIY Daddys Ltd | Real estate | 2025 |
| DJ Rigging Limited | Construction | 2019 |
| DKH Rentals Ltd | Hospitality | 2025 |
| Dkks Management Ltd | Real estate | 2024 |
| DKM Signs Ltd | Manufacturing | 2025 |
| DL IT Services Limited | Information & communication | 2005 |
| DM Direct Trading Ltd | Wholesale & retail | 2024 |
| DM Electrics (NW) Limited | Construction | 2019 |