| Commerce House Wirral Ltd | Administrative & support | 2015 |
| Complete Commando Ltd | Education | 2020 |
| Complete Works Performance School Limited | Arts & recreation | 2016 |
| Complete Workspace Group Ltd | Wholesale & retail | 2025 |
| Composite Design and Fabrication Limited | Professional & scientific | 2022 |
| Composite Door Store Ltd | Wholesale & retail | 2022 |
| Condiment Cupboard Ltd | Manufacturing | 2025 |
| Connectapipe Limited | Wholesale & retail | 2020 |
| Construction Planning Limited | Construction | 2018 |
| Contact Finance Limited | Financial services | 2007 |
| Converte Global Ltd | Manufacturing | 2024 |
| Conway Street Food & Dessert Limited | Hospitality | 2024 |
| Cookcooks Limited | Hospitality | 2023 |
| Copacobana Classics Ltd | Wholesale & retail | 2020 |
| Copland Fiberoptics Ltd | Other services | 2022 |
| Cora Events Ltd | Hospitality | 2025 |
| Core Distribution Ltd | Wholesale & retail | 2020 |
| Core IT Limited | Information & communication | 2015 |
| Core Project Birkenhead CIC | Administrative & support | 2019 |
| Core Trade Supplies Limited | Wholesale & retail | 2023 |
| Corefitz Solutions Ltd | Professional & scientific | 2016 |
| Coreoptimise Ltd | Manufacturing | 2025 |
| Corinthian Welding & Fabrication Ltd | Manufacturing | 2025 |
| Corke Accountancy Services Limited | Professional & scientific | 2019 |
| Cornelia Trading Limited | Financial services | 2025 |
| Corporate Commando Ltd | Arts & recreation | 2024 |
| Corrotec Limited | Manufacturing | 2023 |
| Cortex Group Ltd | Information & communication | 2022 |
| Corvidae Jones Ltd | Administrative & support | 2023 |
| Cottage Street Commercial Limited | Real estate | 2025 |
| Cottonson Limited | Wholesale & retail | 2024 |
| County Cost Consultants Limited | Administrative & support | 2001 |
| Courtney Chan Hair Design Ltd | Other services | 2014 |
| Covella Limited | Wholesale & retail | 2010 |
| Coverall Roofing and Developments Ltd | Construction | 2022 |
| Coverplus Finance Limited | Administrative & support | 2000 |
| CPL UK Southern Ltd | Wholesale & retail | 2014 |
| CR Pulse Ltd | Information & communication | 2019 |
| Crawf Ltd | Wholesale & retail | 2026 |
| CRE8IVE Consulting Ltd | Professional & scientific | 2010 |
| Creating Understandings Psychology Ltd | Health & social care | 2024 |
| Creation Tech Ltd | Information & communication | 2022 |
| Creative Design Landscapes Ltd | Construction | 2020 |
| Cressington Place Management Company Limited | Construction | 2008 |
| Critical AGE Ltd | Health & social care | 2024 |
| Croeso Hotels (Haverfordwest) Ltd | Hospitality | 2021 |
| Crofthey Holdings Ltd | Financial services | 2015 |
| Crompton Property Investments (NW) Ltd | Real estate | 2026 |
| Cross and Co Electrical NW Limited | Construction | 2024 |
| Cross Hill Properties Limited | Real estate | 1991 |
| Crow Flies Travel Ltd | Transport & logistics | 2015 |
| Crowder & Co Limited | Information & communication | 1994 |
| Crown Roofing NW Limited | Construction | 2019 |
| CRT Investments Ltd | Real estate | 2013 |
| Crunchy Software Ltd | Information & communication | 2023 |
| Cryoclinic (North West) Limited | Health & social care | 2019 |
| Crystal Clean Wirral Ltd | Administrative & support | 2022 |
| Crystal Clear Window Systems Ltd | Manufacturing | 2016 |
| CS Windows Limited | Extraterritorial | 2017 |
| CSA Systems Ltd | Extraterritorial | 2021 |
| CSJ Domestic Services Ltd | Administrative & support | 2024 |
| CSJ Leasings Ltd | Real estate | 2025 |
| CSP Homes NW Ltd | Construction | 2023 |
| CSR Tuning Ltd | Wholesale & retail | 2025 |
| CTJ Trading Limited | Wholesale & retail | 2017 |
| Cubicle Works Ltd | Manufacturing | 1985 |
| Cuero Ltd | Real estate | 2021 |
| Cullen Construction (NW) Ltd | Construction | 2023 |
| Cult Coffee Ltd | Hospitality | 2019 |
| Cumbria Invest Ltd | Health & social care | 2023 |
| Current Care Electrical Services Limited | Construction | 2026 |
| Curtis Radiology Ltd | Health & social care | 2019 |
| Curzon Rose Limited | Administrative & support | 2013 |
| Custom Wraps and Tints Ltd | Wholesale & retail | 2025 |
| Cut'N'Shave(Birkenhead) Ltd | Other services | 2019 |
| CVC251 Management Ltd | Real estate | 2025 |
| CW Expert Physio Ltd | Health & social care | 2026 |
| CW Transport Limited | Transport & logistics | 2017 |
| Cymro 2021 | Financial services | 2022 |
| D & a Property Services Limited | Professional & scientific | 2014 |
| D & S Fabrication & Welding Ltd | Construction | 2017 |
| D Carl Jones Ltd | Health & social care | 2012 |
| D J Jackson (UK) Ltd | Transport & logistics | 2008 |
| D L Jones Surveying Services Limited | Professional & scientific | 2019 |
| D&S Properties North West Ltd | Real estate | 2025 |
| D.E. Griffiths (Butchers) Limited | Wholesale & retail | 1982 |
| D.M.C Northwest Group Ltd | Construction | 2026 |
| D.W.Fencing (Cheshire) Limited | Construction | 1991 |
| D247AUTOSERVICES Ltd | Professional & scientific | 2026 |
| D2ISYSTEMS Limited | Information & communication | 2006 |
| DADONE8 Ltd | Real estate | 2025 |
| DADONE88 Ltd | Real estate | 2025 |
| Dadu Limited | Hospitality | 2026 |
| Daibelle Ltd | Information & communication | 2021 |
| Daisygro Limited | Wholesale & retail | 2016 |
| Dalby Fire Limited | Public administration | 2019 |
| Damp Safe Developments Ltd | Construction | 2025 |
| DAN Skillen Property Ltd | Real estate | 2024 |
| Danad Ltd | Real estate | 2022 |
| Daniel Labno Interpreting Ltd | Professional & scientific | 2023 |