| Rolleston Dairy Limited | Agriculture & fishing | 2026 |
| Roof Warehouse Limited | Construction | 2018 |
| Roots Creative Marketing Ltd | Professional & scientific | 2016 |
| ROS Contracting Ltd | Construction | 2016 |
| Rose & Tucker Construction Limited | Construction | 2022 |
| Rosedown Mill Limited | Agriculture & fishing | 1994 |
| Rosehill (Bideford) Limited | Health & social care | 2024 |
| Rosko Services Ltd | Construction | 2016 |
| Roundswell Company Limited | Financial services | 2025 |
| Rowan Homes (SW) Limited | Construction | 2004 |
| ROY Watts & Sons Limited | Construction | 2002 |
| RS Kleenz Ltd | Administrative & support | 2025 |
| Rsd-Uk Ltd | Wholesale & retail | 2025 |
| RSJ Bookkeeping LLP | | 2021 |
| Runes GIN Ltd | Wholesale & retail | 2025 |
| Runland Park Limited | Information & communication | 1982 |
| Rural Care (North Devon) Ltd | Other services | 2015 |
| Rustic Roots Craft Co Limited | Wholesale & retail | 2023 |
| Ryan Ashton Coaching Ltd | Other services | 2026 |
| S & K Pomeroy LLP | | 2020 |
| S J Symons & SON Limited | Extraterritorial | 2017 |
| S L M Homes Ltd | Hospitality | 2023 |
| S&L Home Cleaning Service Limited | Administrative & support | 2025 |
| S&P Gent Limited | Financial services | 2025 |
| S&W Automotive Ltd | Wholesale & retail | 2023 |
| S.R. Arnold Ltd | Construction | 2003 |
| S.T.Ruggling Ltd | Construction | 2025 |
| Sacred Vapes Ltd | Wholesale & retail | 2022 |
| Safe Harbour Investments Ltd | Professional & scientific | 2013 |
| Safe Heating & Plumbing LLP | | 2019 |
| Safe T Solutions SW Ltd | Administrative & support | 2025 |
| Safety Access & Rescue Limited | Other services | 2014 |
| Safety Access and Rescue Training Limited | Other services | 2025 |
| Safety Supplies Direct Ltd | Administrative & support | 2020 |
| Sally Ltd | Administrative & support | 2005 |
| Sally Nichols & Associates LLP | | 2025 |
| Saltline Campers Limited | Wholesale & retail | 2020 |
| Salvx Skin Ltd | Wholesale & retail | 2025 |
| Sandpiper Cottage (Willingcott) Ltd | Hospitality | 2023 |
| Sands Pharma Consultancy Ltd | Professional & scientific | 2026 |
| Sarsons Property (SW) Limited | Real estate | 2026 |
| Sawyer Associates Limited | Real estate | 2007 |
| SAY Something Creative Ltd | Information & communication | 2024 |
| SB Motor Trade Ltd | Wholesale & retail | 2026 |
| Schein UK Ltd | Wholesale & retail | 2025 |
| Schofield Property Group Ltd | Real estate | 2018 |
| Scope Architecture Ltd | Professional & scientific | 2018 |
| Scotts (London) Ltd | Wholesale & retail | 2014 |
| Scotty Kitt Limited | Other services | 2021 |
| SD Music Supplies Ltd | Manufacturing | 2017 |
| Sea Lion (Devon) Ltd | Mining & quarrying | 2017 |
| Seahorse Creative Limited | Professional & scientific | 2020 |
| Seascape Management Company Westward HO! Limited | Households | 2016 |
| Seaside at Nassau Limited | Real estate | 2024 |
| Seasons Ecology Limited | Professional & scientific | 2018 |
| Second Key Limited | Administrative & support | 2021 |
| Seed & Roots Holdings Limited | Financial services | 2023 |
| Seed & Roots Limited | Administrative & support | 2023 |
| Seldons LLP | | 2010 |
| Semacom Limited | Professional & scientific | 2018 |
| Semantic Trading Ltd | Information & communication | 2017 |
| Semma Homes Limited | Real estate | 2016 |
| Sentinel Builders Ltd | Construction | 2020 |
| Sentry Corner Corporate Services Ltd | Information & communication | 2020 |
| Serene Skye Fishing Ltd | Agriculture & fishing | 2020 |
| Seymour Places Ltd | Hospitality | 2016 |
| SG Editorial Services Limited | Information & communication | 2014 |
| Shaizi Trading Limited | Wholesale & retail | 2025 |
| Shamrock Cottages Ltd | Administrative & support | 1996 |
| Shamwickshire House Limited | Hospitality | 2008 |
| Shardelow Designs Ltd | Professional & scientific | 2006 |
| SHELLAC4U Limited | Wholesale & retail | 2014 |
| SHOOT2EDIT Limited | Information & communication | 2002 |
| Shooters Sports Bar LLP | | 2024 |
| Shore Drift Ltd | Wholesale & retail | 2016 |
| Shoreline (SW) Ltd | Construction | 2023 |
| Shortie Electrical LLP | | 2021 |
| Shourage Limited | Professional & scientific | 1992 |
| Silonyx Limited | Transport & logistics | 2001 |
| Simply Concept Limited | Manufacturing | 2018 |
| Sirrom Homes Ltd | Real estate | 2016 |
| SIXTEEN88 Limited | Wholesale & retail | 2017 |
| SIXTEEN88 Retail Limited | Extraterritorial | 2024 |
| Sixton-Brend Group Limited | Financial services | 2025 |
| Sixton-Brend Trading Company Limited | Hospitality | 2025 |
| Sjbl Holdings Limited | Financial services | 2022 |
| Skinners Engineering Limited | Manufacturing | 2013 |
| Sktd Limited | Construction | 2026 |
| Sloan's Spaces Limited | Real estate | 2020 |
| Slotunit Residents Management Limited | Households | 1988 |
| Smart Landscaping Limited | Construction | 2011 |
| Smart Manufacturing Limited | Manufacturing | 2009 |
| Snapdragons Pre-School | Education | 2012 |
| Sodhi Ankamma Enterprises Limited | Wholesale & retail | 2024 |
| Software Craftsmanship Limited | Information & communication | 2022 |
| Solairex Limited | Professional & scientific | 2016 |
| Solo Retail Limited | Wholesale & retail | 2011 |
| Solo Retail Trustees Limited | Administrative & support | 2025 |
| Sothersqs (Hants) Ltd | Professional & scientific | 2025 |
| Soulcarers Ltd | Health & social care | 2020 |