| Soundguard Acoustics Ltd | Professional & scientific | 2008 |
| Sourcing Concepts Limited | Administrative & support | 2009 |
| South Coast Installers Ltd | Construction | 2025 |
| South West Eco Facilities Ltd | Construction | 2020 |
| South West Event Management Solutions CIC | Health & social care | 2022 |
| South West Fabrications Ltd | Manufacturing | 2011 |
| South West Fitted Kitchens Ltd. | Administrative & support | 2017 |
| South West Locations Limited | Information & communication | 2017 |
| South West Paving Contractors Limited | Construction | 2019 |
| Southcott Support Services Ltd | Health & social care | 2008 |
| Southern Alarm Services Limited | Construction | 2019 |
| Southern Coast Care Ltd | Health & social care | 2019 |
| Southern Environmental Contracts Limited | Other services | 2010 |
| Southside Photography Ltd | Professional & scientific | 2009 |
| Sparrex Limited | Arts & recreation | 2013 |
| Speed Dial Ltd | Wholesale & retail | 2009 |
| Speke Valley Services Limited | Real estate | 1979 |
| SPORTY40 Ltd | Professional & scientific | 2026 |
| Spring Avon Ltd | Hospitality | 2025 |
| Spring Elizabeth Ltd | Administrative & support | 2024 |
| Spring Events 1 Ltd | Administrative & support | 2024 |
| Spring Lodges 1 Ltd | Hospitality | 2023 |
| Spring Towan Ltd | Hospitality | 2025 |
| SPS Press Limited | Administrative & support | 2009 |
| Squires Garages (Barnstaple) Limited | Real estate | 1959 |
| SR Furniture Limited | Manufacturing | 2010 |
| SR Mini Loads Ltd | Transport & logistics | 2021 |
| Ssbc Contractors Ltd | Construction | 2022 |
| ST Cross Creative Services Limited | Administrative & support | 1998 |
| ST Helens Property Management North Devon Ltd | Real estate | 2024 |
| ST Michael's Learning Centres Limited | Health & social care | 2013 |
| Stables Foods Ltd | Manufacturing | 2010 |
| Stafford House Properties Ltd | Hospitality | 2016 |
| Staines Builders Limited | Construction | 2019 |
| Staines Engineering Limited | Construction | 2019 |
| Staines Hire Limited | Construction | 2019 |
| Stairway to Devon Ltd | Hospitality | 2022 |
| Stand 2 Protection Ltd | Administrative & support | 2025 |
| Staples and Vine Ltd | Manufacturing | 1996 |
| Starfish Holiday Cottages Ltd | Hospitality | 2017 |
| Starlings Cottage Ltd | Hospitality | 2023 |
| Stashby Limited | Information & communication | 2014 |
| Stay in Media Limited | Extraterritorial | 2010 |
| Steadystyle Limited | Manufacturing | 2026 |
| Stefan Spiby Building Contractor Ltd | Construction | 2023 |
| Step Into Clarity Limited | Education | 2025 |
| Steve Birch Roofing Ltd | Construction | 2016 |
| Stibb Cross Management Company Limited | Households | 2022 |
| Stibb Cross Warren Limited | Households | 2021 |
| Sticker Garage UK Ltd | Professional & scientific | 2021 |
| Stoke Barton LLP | | 2024 |
| Stoned Pizza Limited | Hospitality | 2016 |
| Store and More Limited | Administrative & support | 2014 |
| Storeys and Tails Ltd | Wholesale & retail | 2021 |
| Storkey Property Development Ltd | Real estate | 2022 |
| Storkey Property Management Ltd | Households | 2023 |
| Strathmore Court Management Company Limited | Households | 2005 |
| Strawberry Ventures Limited | Hospitality | 2011 |
| Strouds Woodworking Company Limited | Manufacturing | 2003 |
| Stuart Lamble Designs LLP | | 2025 |
| Substrata Limited | Professional & scientific | 2016 |
| Suck IT Vapes Ltd | Administrative & support | 2022 |
| Summerhouse Conservatories (South West) Limited | Construction | 2010 |
| Sun and Lune Ltd | Hospitality | 2023 |
| Sunleys Services Ltd | Administrative & support | 2015 |
| Sunrise Recovery CIC | Health & social care | 2025 |
| Surf Bay Motor Homes Ltd | Wholesale & retail | 2025 |
| Surf Bay Properties Limited | Real estate | 2021 |
| Surf SUP Academy Limited | Arts & recreation | 2023 |
| Surfice Limited | Administrative & support | 2011 |
| Surgebuster Limited | Professional & scientific | 2002 |
| Survival Paintball Limited | Arts & recreation | 2004 |
| Sussex and Rose Ltd | Hospitality | 2021 |
| SW Fitness Ltd | Arts & recreation | 2012 |
| Swingdon Renewables Ltd | Manufacturing | 2013 |
| Swiss Technologies Ltd | Manufacturing | 2024 |
| Switched on Electrical (SW) Ltd | Construction | 2026 |
| Swivna Ltd | Wholesale & retail | 2019 |
| SWW Commercial and Property Services Ltd | Construction | 2019 |
| Symbro Group Limited | Financial services | 2014 |
| Symbro Ltd | Wholesale & retail | 2006 |
| Symbro Retail Limited | Hospitality | 2024 |
| Symmetric Recruitment Ltd | Administrative & support | 2021 |
| Synergy Eco Electrical Ltd | Construction | 2026 |
| Systematic Innovation Ltd | Education | 2007 |
| T B Pett Limited | Manufacturing | 2018 |
| T Bellas Fishing Ltd | Agriculture & fishing | 2025 |
| T&T Shellfish Ltd | Wholesale & retail | 2014 |
| TA GAS (SW) Ltd | Energy | 2003 |
| Tabspace Ltd | Information & communication | 2019 |
| Tadworthy Management Company Ltd | Households | 2021 |
| Taffs Trading Ltd | Hospitality | 2020 |
| Tails & Twine Ltd | Wholesale & retail | 2025 |
| Tap-Cnc Ltd | Manufacturing | 2026 |
| Tarka Accommodation Ltd | Other services | 2022 |
| Tarka CAD Design Limited | Professional & scientific | 2023 |
| Tarka Clinics Ltd | Health & social care | 2003 |
| Tarka Construction Ltd | Construction | 2020 |
| Tarka Design & Media Ltd | Professional & scientific | 2021 |
| Tarka Diner Ltd | Hospitality | 2021 |