| Shark Ebikes Ltd | Extraterritorial | 2024 |
| Sharon Drew Sales & Commercial Consulting Limited | Professional & scientific | 2025 |
| Shave Ice Company Ltd | Wholesale & retail | 2012 |
| Shaw Bookkeeping Limited | Administrative & support | 2010 |
| Shepherds Rest Beverley Limited | Households | 2020 |
| Sheriff Bar Limited | Hospitality | 2018 |
| Shift Key Theatre Limited | Extraterritorial | 2021 |
| Shiryon Investments Limited | Professional & scientific | 2014 |
| Shoppingslide Ltd | Construction | 2018 |
| Shore Care Services Limited | Health & social care | 2021 |
| Siba Enterprises Ltd | Wholesale & retail | 2025 |
| Side Events Ltd | Administrative & support | 2025 |
| Signal Solvers Ltd | Construction | 2019 |
| Signature Rental Services Ltd | Real estate | 2023 |
| Signford Limited | Manufacturing | 1992 |
| Silverthorn Change Limited | Professional & scientific | 2021 |
| Simax Care Limited | Health & social care | 2011 |
| Simpatico Communications Limited | Information & communication | 2016 |
| Simple Life Beauty Ltd | Wholesale & retail | 2024 |
| Simpleslice Limited | Wholesale & retail | 2006 |
| Simply Breathe Holdings Limited | Professional & scientific | 2019 |
| Simply Breathe Ltd | Manufacturing | 2012 |
| Simpsons Seafoods Limited | Hospitality | 2015 |
| SIN City Spirits Ltd | Wholesale & retail | 2023 |
| Single Stone Construction Company Ltd | Construction | 2017 |
| Sirinthra Thai Massage Therapy Limited | Other services | 2026 |
| Siro Recruitment Ltd | Administrative & support | 2015 |
| Sisko Studio Ltd | Real estate | 2026 |
| SJH Welding Services Limited | Other services | 2016 |
| SJN (East Yorkshire) Limited | Financial services | 2019 |
| SJN Commercial (East Yorkshire) Limited | Real estate | 2019 |
| SJN Developments Limited | Construction | 2019 |
| SJN Project Services Limited | Information & communication | 2016 |
| SJN Residential Limited | Real estate | 2019 |
| SJS Holiday Letting Ltd | Hospitality | 2019 |
| SK Cards & Gifts Limited | Wholesale & retail | 2026 |
| Skcm Private Limited | Real estate | 2017 |
| Skelmersdale Funeral Service Limited | Other services | 2000 |
| Sklifecoach UK Ltd | Other services | 2019 |
| Skylatech Ltd | Manufacturing | 2025 |
| Skyline (I) Limited | Professional & scientific | 2022 |
| Skyrise Creative Ltd | Professional & scientific | 2020 |
| SLB Properties (PVT) Ltd | Real estate | 2024 |
| SLH Safety Ltd | Professional & scientific | 2026 |
| Slice Marketing (Hull) Limited | Professional & scientific | 2019 |
| SLM Training Limited | Education | 2024 |
| SM Parker Ltd | Health & social care | 2008 |
| SM Site Services Limited | Other services | 2022 |
| Smart Card World Ltd | Professional & scientific | 2010 |
| Smart GAS Limited | Construction | 2022 |
| Smart Machine Company Limited | Administrative & support | 2003 |
| Smarttech Digital Ltd | Information & communication | 2026 |
| SMD Property Limited | Hospitality | 2019 |
| SMG Works Ltd | Professional & scientific | 2025 |
| Smith's Refrigeration Ltd | Manufacturing | 2014 |
| Smugglers (Fish & Chip Bar) Limited | Hospitality | 2012 |
| Snack Tech Consulting Ltd | Professional & scientific | 2020 |
| Snake Bite Coffee Limited | Wholesale & retail | 2021 |
| Snic Rail Ltd | Manufacturing | 2023 |
| Snic Rail UK Ltd | Manufacturing | 2019 |
| Social Socials Limited | Information & communication | 2024 |
| Social Tech Beverley Limited | Information & communication | 2026 |
| Socially Automated Ltd | Information & communication | 2025 |
| Sofran Ltd | Information & communication | 2019 |
| Soju Beverley Ltd | Hospitality | 2020 |
| Sold Estates Limited | Real estate | 2013 |
| Solo One Fitness Ltd | Arts & recreation | 2022 |
| Sommer House Ltd | Real estate | 2015 |
| Soncon Limited | Professional & scientific | 2010 |
| Southfleet Management Company (Hull) Limited | Households | 1975 |
| Southwell County Homes Limited | Construction | 2008 |
| Sowerby FRS LLP | | 2004 |
| Spencer Engineering Solutions Ltd | Professional & scientific | 2024 |
| Spencer Street Development Management Company Limited | Real estate | 1983 |
| Spindle Thorn Limited | Construction | 2002 |
| Spiritus Health Limited | Health & social care | 2024 |
| Sport Vision Limited | Professional & scientific | 2019 |
| Sports 2000 Racing Car Club Ltd | Arts & recreation | 2020 |
| Sports Stars Academy Limited | Arts & recreation | 2023 |
| Squires Close (Sherburn) Management Company Limited | Households | 2010 |
| SRB Process Consulting Ltd | Professional & scientific | 2025 |
| SRC Property Hull Ltd | Real estate | 2021 |
| SRC Site Engineering Limited | Construction | 2024 |
| SS Beverley Ltd | Hospitality | 2018 |
| ST Andrews Court (Hull) Management Co Limited | Real estate | 2007 |
| ST Crispins Antiques & Collectors Centre Limited | Wholesale & retail | 2018 |
| ST Helens Garth Management Co Limited | Real estate | 2012 |
| ST Mary's Manor (Beverley) Limited | Households | 1999 |
| Stable Bistro Ltd | Hospitality | 2007 |
| Stack Hornsea Ltd | Hospitality | 2024 |
| Stackhouse Bar Hornsea Ltd | Hospitality | 2019 |
| Stainforth Haulage Ltd | Transport & logistics | 2014 |
| Stamford Property Developments Limited | Construction | 2009 |
| Stanbury Properties Limited | Financial services | 2002 |
| Standwall Developments Ltd | Construction | 2008 |
| Star Nails Beverley Ltd | Other services | 2024 |
| Starcross Partnership Ltd | Real estate | 2008 |
| Starspan Ltd | Professional & scientific | 2020 |
| State of Flux Services Ltd | Professional & scientific | 2023 |
| Staysmart Grounds Maintenance Ltd | Administrative & support | 2019 |