| Rpms Block & Facilities Management Limited | Households | 2020 |
| RR TANNING2 Limited | Other services | 2023 |
| RRJ Solutions Limited | Health & social care | 2023 |
| RSH Civil Engineering & Construction Services Ltd | Professional & scientific | 2026 |
| Rubicon Commissions Limited | Administrative & support | 2016 |
| Rubicon Consultants Limited | Professional & scientific | 1979 |
| Rugby Union. COM Ltd | Professional & scientific | 2026 |
| Rugbytots Harrogate LLP | | 2019 |
| Rural ELM Limited | Professional & scientific | 2021 |
| Russell Ombler Ltd | Administrative & support | 2019 |
| Rutter Property Limited | Real estate | 2025 |
| Rydal Properties Limited | Real estate | 2015 |
| S & J Enterprises (U.K.) Limited | Real estate | 1999 |
| S & M Scaffolding Ltd | Construction | 2008 |
| S & P Fabrications Limited | Construction | 1986 |
| S & R Business Services (East Yorkshire) Limited | Professional & scientific | 2002 |
| S & S Site Services (Nationwide) Limited | Construction | 2003 |
| S & W Riding Funerals Limited | Other services | 2007 |
| S C Electrical Engineers Limited | Construction | 2020 |
| S C Humber Limited | Construction | 2011 |
| S D Barker Construction Limited | Construction | 2004 |
| S L Marine Crane Hire Limited | Administrative & support | 2006 |
| S L Marine Limited | Other services | 2006 |
| S L Property Innovation Limited | Real estate | 2025 |
| S&A Ice Blasting Limited | Administrative & support | 2023 |
| S.J.S. Flooring Limited | Construction | 2008 |
| S.N.G.A.S. Limited | Health & social care | 2009 |
| S.P. Smedley Limited | Construction | 2006 |
| S2 Data Analytics Ltd | Information & communication | 2026 |
| Sabre Technology (Hull) Limited | Professional & scientific | 1995 |
| Safe 'N' Sound Nurseries & Pre-Schools Limited | Education | 2002 |
| Safeguarding Futures Ltd | Other services | 2017 |
| Safety & Environmental Management Systems Limited | Professional & scientific | 2014 |
| Safety Assured Services Limited | Professional & scientific | 2018 |
| Sahindal Limited | Hospitality | 2018 |
| Salar Ventures Limited | Financial services | 2017 |
| Sales and Business Guru Ltd | Wholesale & retail | 2025 |
| Salt and Wild Limited | Wholesale & retail | 2025 |
| SAM Hollis Web Design Ltd | Information & communication | 2017 |
| Sam's Way Services Limited | Transport & logistics | 2023 |
| Samlet Ec&I Engineering Ltd | Professional & scientific | 2018 |
| Samlet Property Ltd | Real estate | 2020 |
| Samuel Kendall Associates Limited | Professional & scientific | 2005 |
| Sandersons Mews Management Company Limited | Real estate | 2007 |
| Sangwin & Sons Ltd | Construction | 2021 |
| Sangwin Architects Ltd | Professional & scientific | 2011 |
| Sans Personal Care Ltd | Wholesale & retail | 2019 |
| Sapling Education Ltd | Information & communication | 2024 |
| Sasshnb Ltd | Other services | 2025 |
| Sasso Automotive Limited | Wholesale & retail | 2015 |
| Sattire Ltd | Wholesale & retail | 2024 |
| Saturday Market PUB Co Ltd | Hospitality | 2021 |
| Savemart Limited | Wholesale & retail | 1987 |
| Savvybuy Digital Culture Limited | Wholesale & retail | 2024 |
| Sawlb Limited | Real estate | 2023 |
| Saxon Computing Solutions Ltd | Information & communication | 2018 |
| SBL Investment Limited | Real estate | 2020 |
| SBS Property Investment Limited | Real estate | 2021 |
| SC 61 Ltd | Construction | 2025 |
| SC Foods Ltd | Hospitality | 2022 |
| Scarborough Athletic Community Trust | Education | 2023 |
| Scarlet Lounge Limited | Hospitality | 2010 |
| School Business Management Solutions Ltd | Professional & scientific | 2014 |
| Schrodinger MMC Solutions Limited | Construction | 2022 |
| Scoop Graphics Ltd | Professional & scientific | 2010 |
| Scorborough Sporting Limited | Agriculture & fishing | 2008 |
| Scotney Limited | Real estate | 2005 |
| Scott Clark Electrical Ltd | Construction | 2013 |
| Scott Wiseman Ltd | Financial services | 2017 |
| Scott’S Caravan Services Ltd | Manufacturing | 2025 |
| Scqs Ltd | Professional & scientific | 2001 |
| Screw Pressing Technology Limited | Wholesale & retail | 2020 |
| SD Essential Health Ltd | Health & social care | 2022 |
| SE Energy Limited | Professional & scientific | 2025 |
| Seamer Power Limited | Energy | 2017 |
| Seapoint Properties (Filey) Ltd | Real estate | 2023 |
| Search and Rescue Trading Company Ltd | Wholesale & retail | 2013 |
| Search Auth Ltd | Information & communication | 2020 |
| Sector Civil Engineering Limited | Construction | 2020 |
| Securemedia Ltd | Information & communication | 2010 |
| Security Direct Products Limited | Manufacturing | 2010 |
| Select Homes (BTL) Limited | Real estate | 2025 |
| Select Stone Ltd | Other services | 2020 |
| Self Stor Limited | Transport & logistics | 2020 |
| Selfnode Ltd | Information & communication | 2026 |
| Selnat Ltd | Real estate | 2020 |
| Senco Software Limited | Information & communication | 2007 |
| Sendpilot Limited | Information & communication | 2025 |
| Sentiments Independent Funeral Home Ltd | Other services | 2012 |
| Serendipity Care Yorkshire Limited | Health & social care | 2024 |
| Serial Data Systems Limited | Information & communication | 1999 |
| Service and Sweeps Limited | Administrative & support | 2015 |
| Setgear Residents Association Limited | Households | 1985 |
| Sewell Law Limited | Professional & scientific | 2020 |
| SFL Management Limited | Financial services | 2018 |
| SFS Calcs Ltd | Construction | 2020 |
| Shamichef Limited | Information & communication | 2023 |
| Sharewell Residential Limited | Real estate | 2013 |
| Sharewood Estates Ltd | Real estate | 2017 |
| Shark Bikes Ltd | Manufacturing | 2020 |