| Steampunkeddecor Ltd | Wholesale & retail | 2024 |
| Steel Electrical Services Ltd | Construction | 2020 |
| Stephen W Ltd | Construction | 2014 |
| Stephen Whitaker International Limited | Arts & recreation | 2004 |
| Steve Pickering Ltd | Construction | 2008 |
| Steve Riley Driving Services Limited | Transport & logistics | 2017 |
| Steve Squared Solutions Limited | Professional & scientific | 2011 |
| Stipendia Payroll Solutions Limited | Administrative & support | 2013 |
| Stitch and Stash Ltd | Wholesale & retail | 2019 |
| Stock to Trade Ltd | Wholesale & retail | 2023 |
| Stockcare Gold Label Limited | Professional & scientific | 1995 |
| Stoddart S Limited | Wholesale & retail | 2003 |
| Stoddart S Property Holdings Limited | Real estate | 2018 |
| Stone Holdings (Yorkshire) Limited | Financial services | 2020 |
| Stopford Properties Ltd | Real estate | 1999 |
| Strada Music International Limited | Arts & recreation | 2023 |
| Strange & Others Ltd | Professional & scientific | 2025 |
| Strathmore Poplar Ltd | Real estate | 2016 |
| Strawberry Consulting Limited | Professional & scientific | 2022 |
| Strawberry Fields Holiday Park Ltd | Hospitality | 2010 |
| Stress-Tec (UK) Limited | Professional & scientific | 2020 |
| Stroke Specialist Ltd | Health & social care | 2024 |
| Strong Thick Dark Beer Limited | Hospitality | 2025 |
| Structural Frames Limited | Construction | 2013 |
| Strung OUT Audio Ltd | Information & communication | 2015 |
| Stylo Fade Ltd | Wholesale & retail | 2019 |
| Subani Consulting Limited | Professional & scientific | 2006 |
| Succeed and Achieve Tuition Services Ltd | Education | 2024 |
| SUE Cain Properties Limited | Real estate | 2023 |
| Summer Breeze Property Consultants Limited | Professional & scientific | 2023 |
| Summer Oral Care Ltd | Health & social care | 2021 |
| Sungym Ltd | Arts & recreation | 2019 |
| Sunvia Ltd | Construction | 2025 |
| Supply Chain Sourcing Limited | Administrative & support | 2002 |
| Susie and BEN Limited | Real estate | 2024 |
| Sustainable AG Solution's Limited | Wholesale & retail | 2017 |
| Sutana Ltd | Hospitality | 2021 |
| Sutton Design Architectural Limited | Professional & scientific | 2016 |
| Sutton Instruments Ltd | Manufacturing | 2014 |
| Suttons Carpentry & Joinery Limited | Construction | 2018 |
| Suzan Bar Grill Limited | Hospitality | 2019 |
| Swabys & Dyer Management Company Limited | Households | 2025 |
| SWE Solutions Limited | Professional & scientific | 2008 |
| Sweet Success Limited | Professional & scientific | 1998 |
| Swift Direct Distribution Limited | Transport & logistics | 2025 |
| Swincan Group Ltd | Financial services | 2024 |
| Swincan Property Maintenance Ltd | Construction | 2024 |
| Swinemoor Christian Trust | Wholesale & retail | 2004 |
| Sykes Close Beeford Management Ltd | Households | 2019 |
| Syllabubb Limited | Wholesale & retail | 2013 |
| Synergy Forward Limited | Real estate | 2010 |
| Synify Limited | Information & communication | 2024 |
| Sype Consulting Limited | Professional & scientific | 2022 |
| Syron Mainwaring Financial Limited | Extraterritorial | 2017 |
| Syron Mainwaring Ltd | Extraterritorial | 2017 |
| Systems Research Ltd | Professional & scientific | 2012 |
| T & R Motors Hull Ltd | Wholesale & retail | 2021 |
| T Barratt Limited | Administrative & support | 2006 |
| T C Patisserie Limited | Wholesale & retail | 2008 |
| T H Caley and Sons Limited | Agriculture & fishing | 2010 |
| T M Electrical Services (Beverley) Ltd | Other services | 2018 |
| T W Building and Joinery Ltd | Construction | 2026 |
| T. a. Bartlett (Pallets) Limited | Manufacturing | 2012 |
| T.G. Brumfield & SON Limited | Agriculture & fishing | 2012 |
| T.J.C. (Engineering Services) Limited | Manufacturing | 2002 |
| Talented Women Ltd | Professional & scientific | 2026 |
| Talk Psychological Therapies Ltd | Health & social care | 2022 |
| Talking IT Better Ltd | Health & social care | 2021 |
| Tansor Consulting Limited | Professional & scientific | 1996 |
| Tasc Project Management Limited | Professional & scientific | 2021 |
| Tattersall 1959 Limited | Extraterritorial | 2013 |
| TAW Fabrications Ltd | Manufacturing | 2022 |
| Taylor & Aldous Limited | Real estate | 2021 |
| Taylor & Co Property Ltd | Real estate | 2026 |
| Taylor ET AL Management Limited | Administrative & support | 2010 |
| Taylor's Bond Co Ltd | Wholesale & retail | 2019 |
| Taylor’S of Yorkshire Property Ltd | Real estate | 2021 |
| TC East Yorkshire Limited | Professional & scientific | 2019 |
| TDP Construction Services Ltd | Construction | 2025 |
| Teal Developments (Hull) Limited | Real estate | 2018 |
| Teal Estates (UK) Limited | Construction | 2003 |
| Tech Safety Solutions Ltd | Professional & scientific | 2020 |
| Teck Know Limited | Information & communication | 2016 |
| Teckno (Group) Limited | Administrative & support | 2011 |
| Teckno Developments Limited | Manufacturing | 1997 |
| Teckno Management Services Limited | Construction | 2014 |
| Teckno Properties Limited | Real estate | 2003 |
| Tektube Ltd | Other services | 2008 |
| Telecom Synergy (NL) Limited | Information & communication | 2011 |
| Telecom Synergy (UK) Limited | Extraterritorial | 2003 |
| Telli & Darren Brothers Limited | Hospitality | 2011 |
| Tempel Recruitment Ltd | Professional & scientific | 2025 |
| Temperate Isle Ltd | Manufacturing | 2024 |
| Tenaro Limited | Professional & scientific | 2020 |
| TENDER360 Ltd | Professional & scientific | 2024 |
| Terroir Artisanal Chocolates Ltd | Manufacturing | 2025 |
| Tetley Tax Limited | Professional & scientific | 2020 |
| Tetwin Properties Ltd | Hospitality | 2021 |
| TFT Woodexperts Limited | Professional & scientific | 2012 |
| TG Rentals Ltd | Real estate | 2023 |