| Salus Fire Ltd | Construction | 2017 |
| Salvation Homes Limited | Health & social care | 2023 |
| SAM Bedford Painting & Decorating Ltd | Construction | 2023 |
| SAM David Roberts Limited | Information & communication | 2019 |
| Samaz Ltd | Health & social care | 2014 |
| Sambroke Square (Freehold) Limited | Households | 2023 |
| Samcro Limited | Health & social care | 2014 |
| Sammat Investments Ltd. | Construction | 1999 |
| Sammy & Tandy's Consulting & Training Limited | Health & social care | 2016 |
| Sammy's Soul Food Ltd | Hospitality | 2025 |
| Sammyjoh Limited | Professional & scientific | 2016 |
| Sammy’S HAT Ltd | Wholesale & retail | 2023 |
| Samorem Global Limited | Administrative & support | 2016 |
| Samosa Corner Ltd | Hospitality | 2025 |
| Sample Holdings Limited | Real estate | 1995 |
| Sampson Property Consultants Limited | Professional & scientific | 2016 |
| Sampson Property Services Ltd | Real estate | 2017 |
| Sampson Style Ltd | Wholesale & retail | 2025 |
| Sams Home Improvements Limited | Wholesale & retail | 2023 |
| Samsons Limited | Real estate | 2003 |
| Samtom Properties Limited | Real estate | 2023 |
| Samy Private Cooking Ltd | Hospitality | 2025 |
| Samy's Car Sales Ltd | Wholesale & retail | 2009 |
| SAN & SAM Associates Ltd | Health & social care | 2025 |
| Sanctify Ltd | Health & social care | 2020 |
| Sanctum of YOU Ltd | Wholesale & retail | 2024 |
| Sand Cornish Holiday Homes Ltd | Real estate | 2022 |
| Sandalwood Accountants Limited | Professional & scientific | 2022 |
| Sandhu Chiropractic Limited | Health & social care | 2007 |
| Sandhu Global Consulting Ltd | Wholesale & retail | 2024 |
| Sandison Performance Ltd | Arts & recreation | 2025 |
| Sandy Property Maintenance Ltd | Construction | 2024 |
| Sandyworldshop Limited | Wholesale & retail | 2022 |
| Sanfa Solutions Ltd | Wholesale & retail | 2025 |
| Sangerconstructions Ltd | Construction | 2025 |
| Sanghvi JB Ltd | Professional & scientific | 2016 |
| Sanissia Investment Co Ltd | Real estate | 2025 |
| Sanita C Houses Limited | Manufacturing | 2025 |
| Sano Clean Ltd | Administrative & support | 2026 |
| Sansuri Limited | Administrative & support | 2023 |
| Santa's Grotto Ltd | Wholesale & retail | 2017 |
| Santee Santee Limited | Health & social care | 2024 |
| Sapidus LAB Ltd | Wholesale & retail | 2023 |
| Sapo Appliances Ltd | Manufacturing | 2025 |
| Sara Strategic Investments Ltd | Real estate | 2019 |
| Sara UK Homes Ltd | Real estate | 2023 |
| Sarah Adams Consultancy Services Ltd | Information & communication | 2018 |
| Sarah Freestone Ltd | Arts & recreation | 2025 |
| Sarah Lane Limited | Other services | 2009 |
| Sarah Logan HR Consultancy Limited | Professional & scientific | 2025 |
| Sarah Munday Consultancy Ltd | Professional & scientific | 2025 |
| Sarah Root Consulting Limited | Health & social care | 2018 |
| Sarah Viola Limited | Wholesale & retail | 2014 |
| Sara’S Investment Group Limited | Real estate | 2024 |
| Sarpel Ground Works Ltd | Administrative & support | 2019 |
| Sarro Properties Limited | Construction | 2014 |
| Sarrosons Limited | Real estate | 2011 |
| SAS Collections Limited | Administrative & support | 2025 |
| SAS Haulage Limited | Transport & logistics | 2025 |
| SAS Info Tech Ltd | Information & communication | 2017 |
| SAS Supermarket Ltd | Wholesale & retail | 2020 |
| Sasa Transport Ltd | Transport & logistics | 2015 |
| Sastr Ltd | Professional & scientific | 2019 |
| Sasy N Savy Ltd | Wholesale & retail | 2018 |
| SAT Drylining Ltd | Construction | 2019 |
| SAT Tax Ltd | Professional & scientific | 2024 |
| Satcau Limited | Construction | 2022 |
| Sathvik Ltd | Information & communication | 2009 |
| Sats IT Consulting Limited | Information & communication | 2018 |
| Saturn Systems Engineering Limited | Professional & scientific | 2002 |
| Sauce Shed Limited | Manufacturing | 2020 |
| Sauce Shed Logistics Ltd | Transport & logistics | 2021 |
| Saucedbyhs Limited | Wholesale & retail | 2024 |
| SAUD1 Properties Ltd | Real estate | 2021 |
| Saulvic Ltd | Health & social care | 2024 |
| Sauns Ltd | Health & social care | 2014 |
| Savage & Daughters Limited | Professional & scientific | 2013 |
| Savage Civils and Electrical Ltd | Construction | 2025 |
| Savanna Agro Limited | Wholesale & retail | 2020 |
| Savannah Logistic Services Ltd | Water & waste | 2025 |
| Savemove Ltd | Real estate | 2024 |
| Savemystuff Ltd | Other services | 2016 |
| Savin Nurseries Limited | Wholesale & retail | 2025 |
| Saving Hands Ltd | Health & social care | 2021 |
| Saviours Solution Limited | Health & social care | 2023 |
| Savvy Construction Group Ltd | Construction | 2026 |
| Savvy Innovation Limited | Professional & scientific | 2021 |
| Sawtry Day Nursery Ltd. | Administrative & support | 1998 |
| Saxon Skips Ltd | Water & waste | 2021 |
| Saxon Solutions Limited | Professional & scientific | 2019 |
| Saxophone Weddings Ltd | Arts & recreation | 2015 |
| SAY Coffee House Ltd | Hospitality | 2022 |
| SAY Doughnuts (Holdings) Ltd | Financial services | 2023 |
| SAY Doughnuts Ltd | Hospitality | 2020 |
| Saye Doors Ltd | Manufacturing | 2022 |
| Sayer Sales Ltd | Wholesale & retail | 2024 |
| SB Construction (Herts) Ltd | Construction | 2002 |
| SB Properties (Bedford) Limited | Real estate | 2024 |
| Sbayley Administration Limited | Extraterritorial | 2007 |
| Sbayley Services Limited | Extraterritorial | 2007 |