| Sbayleys Investments Limited | Extraterritorial | 2007 |
| SBC London Ltd | Financial services | 2021 |
| Sbmg Services Limited | Transport & logistics | 2018 |
| Sbrown Administration Limited | Extraterritorial | 2007 |
| Sbrown Investments Limited | Extraterritorial | 2007 |
| Sbrown Services Limited | Extraterritorial | 2007 |
| SC BAO Ltd | Transport & logistics | 2018 |
| SC Carpentry and Construction Limited | Construction | 2007 |
| SC Employment Solutions Ltd | Administrative & support | 2026 |
| Scale Your Sales Ltd | Administrative & support | 2024 |
| Scaled Construction Group Ltd | Real estate | 2025 |
| Scarab Services Limited | Administrative & support | 2019 |
| Scared SO What Limited | Professional & scientific | 2022 |
| Scarytown Ltd | Information & communication | 2023 |
| SCB Development Limited | Construction | 2012 |
| Scepta Consulting Ltd | Professional & scientific | 2019 |
| SCG Conditioning Ltd | Arts & recreation | 2014 |
| SCH Presentations Limited | Professional & scientific | 2024 |
| Schemanest Ltd | Information & communication | 2019 |
| Schematix Automation Limited | Professional & scientific | 2026 |
| Schemeta Limited | Information & communication | 2000 |
| Schnell Solutions Limited | Information & communication | 2006 |
| Schoder Factory Ltd | Information & communication | 2018 |
| School Data Managed Limited | Information & communication | 2015 |
| School Lane Great Barford Management Company Limited | Administrative & support | 2005 |
| School of Civil Celebrancy Ltd | Education | 2023 |
| Schoudhury Occhealth Ltd | Health & social care | 2025 |
| Schreiber Associates International Limited | Financial services | 2011 |
| Scientific Marketing Limited | Professional & scientific | 2022 |
| Scimitar Motor Services Ltd | Wholesale & retail | 2000 |
| SCK Group Ltd | Construction | 2018 |
| SCK Scaffolding Limited | Construction | 2024 |
| SCL Properties (MK) Limited | Real estate | 2024 |
| SCO Associates Limited | Information & communication | 2020 |
| Scodaro Limited | Health & social care | 2022 |
| Scolt Head Properties Limited | Real estate | 2025 |
| Scorebridge Limited | Administrative & support | 2018 |
| Scorpio Investments Limited | Financial services | 2024 |
| Scothouseltd Ltd | Wholesale & retail | 2025 |
| Scotswood Industries Limited | Manufacturing | 2013 |
| Scott Hamlyn Ltd | Construction | 2022 |
| Scott Veterinary Clinic Ltd | Professional & scientific | 2023 |
| Scott White and Hookins LLP | | 2013 |
| Scotties Roastery Limited | Hospitality | 2016 |
| Scotties Coffee Limited | Other services | 2013 |
| SCR Utility and Transportation Solutions Ltd | Wholesale & retail | 2026 |
| Screen International Group Limited | Administrative & support | 2016 |
| Screening Eagle UK Limited | Administrative & support | 2009 |
| Scriptwriting Associates Limited | Arts & recreation | 1998 |
| Scritsy Limited | Arts & recreation | 2017 |
| Scrufc Limited | Arts & recreation | 2022 |
| Scrumptious Creative Treats Ltd | Hospitality | 2021 |
| SCS Bedford Limited | Construction | 2018 |
| Scsf Limited | Administrative & support | 2021 |
| Scuba Scaffolding Ltd | Construction | 2024 |
| Sculpt Beauty Laser Ltd | Other services | 2025 |
| Sculpt Beauty Ltd | Health & social care | 2020 |
| Scvc Group Holdings Limited | Construction | 2025 |
| Scvc Tachograph Analysis Services Limited | Professional & scientific | 2025 |
| SCY Holdings Ltd | Professional & scientific | 2026 |
| SD Fashion Ltd | Wholesale & retail | 2018 |
| SDC (Anglia) Limited | Real estate | 1976 |
| SDC (Properties) Limited | Real estate | 1984 |
| SDC Cleaning Limited | Transport & logistics | 2025 |
| SDJ PA Services Limited | Administrative & support | 2019 |
| Sdkproperty Services Limited | Real estate | 2016 |
| SDL Firewall Limited | Construction | 2023 |
| Sdlt Claims Ltd | Professional & scientific | 2011 |
| SDM Distribution Ltd | Transport & logistics | 2023 |
| Sdmm Limited | Construction | 2021 |
| Seabrook Investments Colmworth Limited | Real estate | 2004 |
| Seacross Pharmaceuticals Ltd | Manufacturing | 2011 |
| Seaforth Consulting Limited | Extraterritorial | 2014 |
| Seagull Property Management Ltd | Households | 2019 |
| Seahorse Bikes Limited | Wholesale & retail | 2019 |
| Sealeco Limited | Financial services | 2011 |
| Sean Bailey Builders Limited | Construction | 2017 |
| Sean Buxton Consultancy Ltd | Professional & scientific | 2024 |
| Sean Rose Roofing Ltd | Construction | 2021 |
| Sean White Limited | Construction | 2009 |
| Search Click Convert Ltd | Information & communication | 2024 |
| Seasonal Supplies Ltd | Agriculture & fishing | 2019 |
| Seawillow Limited | Health & social care | 2013 |
| SEB Capital Ltd | Real estate | 2026 |
| SEB Philpott Ltd | Arts & recreation | 2024 |
| Sebastian Building Solutions Ltd. | Construction | 2017 |
| Sebastian Contractors Ltd | Construction | 2015 |
| Sebborn Construction Limited | Construction | 2024 |
| Seber Contracting Limited | Agriculture & fishing | 2025 |
| Sechmond Limited | Information & communication | 2014 |
| Second Croyland Property Company Limited | Extraterritorial | 1965 |
| Second Shift Ltd | Real estate | 2025 |
| Secret Beauty-Waxing and Holistics Ltd | Other services | 2024 |
| Section Eight Contracting Ltd | Wholesale & retail | 2017 |
| Section Nine Consulting Ltd | Information & communication | 2010 |
| Secura Limited | Information & communication | 2025 |
| Secure Analysis Ltd | Professional & scientific | 2023 |
| Secure Debug Limited | Information & communication | 2019 |
| Secure IT Destruction Ltd | Extraterritorial | 2014 |
| Secure IT Disposals Limited | Extraterritorial | 2003 |