| S&I Nexus Ltd | Wholesale & retail | 2025 |
| S&J Holiday Properties Limited | Real estate | 2013 |
| S&J Premier Ltd | Wholesale & retail | 2024 |
| S&K Pro Limited | Real estate | 2026 |
| S&M Connections Ltd | Professional & scientific | 2024 |
| S&S Trading Online Ltd | Wholesale & retail | 2023 |
| S&Sp Contracts Ltd | Professional & scientific | 2020 |
| S&T Destiny Limited | Health & social care | 2020 |
| S&U Logistic Ltd | Transport & logistics | 2011 |
| S-Nia Services Ltd | Health & social care | 2026 |
| S. J. Helliwell Ltd | Construction | 2014 |
| S.A.Smith Limited | Transport & logistics | 2020 |
| S.C Transport & Recovery Ltd | Transport & logistics | 2023 |
| S.D. Investment Group Limited | Financial services | 2025 |
| S.D.C. Builders Limited | Construction | 1976 |
| S.D.G. Electrical and Mechanical Engineering Limited | Construction | 1993 |
| S.E Sparks Electrical Limited | Construction | 2020 |
| S.J Logistics Limited | Transport & logistics | 2026 |
| S.John (Haulage) Limited | Real estate | 1954 |
| S.O. Automation Limited | Information & communication | 2012 |
| S.S Industrial Solutions Ltd | Manufacturing | 2026 |
| S.T.G. Ltd | Transport & logistics | 1994 |
| S.W GAS Works Limited | Construction | 2022 |
| S2 Property Solution Ltd | Construction | 2020 |
| S3 Builders Ltd | Construction | 2014 |
| SA BIZ UK Limited | Information & communication | 2009 |
| SA Consulting Services Limited | Real estate | 1994 |
| SA Global Ventures Ltd | Wholesale & retail | 2026 |
| SAA Enterprise Ltd | Professional & scientific | 2026 |
| Saab Estates Ltd | Construction | 2021 |
| Saai Ltd | Health & social care | 2023 |
| Saak Engineering Limited | Administrative & support | 2015 |
| Saas Magic Ltd | Information & communication | 2025 |
| SAB Scientific Consultancy Ltd | Professional & scientific | 2019 |
| Sabac Ltd | Professional & scientific | 2018 |
| Sabe Interactive Ltd | Information & communication | 2011 |
| Sabnoc Limited | Wholesale & retail | 2003 |
| Sabre Contractors Ltd | Construction | 2024 |
| Sabro Logistics Ltd | Transport & logistics | 2014 |
| Sabz Executive Cars Ltd | Transport & logistics | 2025 |
| Sacha Course Limited | Professional & scientific | 2002 |
| Sacha Harding Performance Coaching Limited | Arts & recreation | 2016 |
| Sackville Forge Ltd | Agriculture & fishing | 2021 |
| Sacred Symphony Limited | Information & communication | 2011 |
| Sadat Limited | Health & social care | 2026 |
| SAE Ventures Ltd | Administrative & support | 2024 |
| Saee Limited | Real estate | 2024 |
| Saem Ltd | Hospitality | 2024 |
| SAF Bedford Enterprises Ltd | Wholesale & retail | 2026 |
| SAF Bedford Holdings Ltd | Wholesale & retail | 2022 |
| SAF Distribution Limited | Transport & logistics | 2022 |
| Safar E Umrah Ltd | Administrative & support | 2026 |
| Safarik Ltd | Construction | 2020 |
| Safe Cars MK Limited | Wholesale & retail | 2019 |
| Safe Hands Care Group Ltd | Other services | 2025 |
| Safe Point Services Ltd | Health & social care | 2023 |
| Safedine Technology Ltd | Information & communication | 2023 |
| Safeguard Build Ltd | Construction | 2026 |
| Safer Charging Limited | Manufacturing | 2024 |
| Safespark Electrical & Plumbing Ltd | Construction | 2020 |
| Safety Biomedical Ltd | Professional & scientific | 2007 |
| Safety Consulting Partnership Limited | Professional & scientific | 2011 |
| Safety Logistics Ltd | Transport & logistics | 2025 |
| Safety Studio Associates Limited | Professional & scientific | 2024 |
| Safety Symbiosis Ltd | Professional & scientific | 2024 |
| Safeway Unlocked Limited | Wholesale & retail | 2022 |
| Saffron (Papworth) Ltd | Other services | 2019 |
| Saffron Bricks Ltd | Real estate | 2024 |
| Saffron Residents Association Limited | Households | 1975 |
| Saffron Xpress Ltd | Hospitality | 2020 |
| Safi and Sons Limited | Health & social care | 2022 |
| Sagarsons (UK) Limited | Wholesale & retail | 2018 |
| Sage Baobab Limited | Professional & scientific | 2025 |
| SAH Solutions Limited | Financial services | 2017 |
| Saharm Limited | Health & social care | 2023 |
| Sahih Devs Limited | Information & communication | 2022 |
| SAI G Estates Ltd | Real estate | 2024 |
| SAI Handicrafts Ltd | Wholesale & retail | 2018 |
| SAI Prime Limited | Real estate | 2020 |
| SAI Siddhivinayak Ventures Ltd | Hospitality | 2025 |
| Saigal Prime Limited | Wholesale & retail | 2026 |
| Saige Interiors Ltd | Manufacturing | 2019 |
| Saint David's Private Members Club Ltd | Arts & recreation | 2019 |
| Saint Joseph T/A Four Seasons Motors Ltd | Wholesale & retail | 2023 |
| Saints - Striving Athletes Inspiring Nurturing Transforming for Success Ltd | Arts & recreation | 2016 |
| Saints Estates Agents Ltd | Real estate | 2023 |
| Saints Retail Ltd | Wholesale & retail | 2023 |
| Sajscardsncreps Ltd | Wholesale & retail | 2025 |
| Sakaa Ltd | Real estate | 2011 |
| Saks Estates Ltd | Construction | 2020 |
| Salamandridae Limited | Hospitality | 2010 |
| Salcey Pine Limited | Manufacturing | 2007 |
| Salcey Properties Limited | Real estate | 2019 |
| Salerno Homewares Limited | Professional & scientific | 2015 |
| Salerno Investments Limited | Financial services | 2018 |
| Salford ORL Inns Limited | Hospitality | 2017 |
| Salieymara Cosmetics Limited | Wholesale & retail | 2024 |
| Sally Abbotts Ltd | Professional & scientific | 2017 |
| Salon Collective Bedford Limited | Other services | 2024 |
| Salon GLD Limited | Other services | 2025 |