| Dion Express Ltd | Transport & logistics | 2024 |
| Discover.He CIC | Education | 2025 |
| Distraction Freehouses Limited | Hospitality | 2025 |
| DJ Oral Healthcare Ltd | Health & social care | 2025 |
| DJH Solutions Ltd | Construction | 2009 |
| DJP Developments Limited | Construction | 2007 |
| DJT Roofing Limited | Construction | 2016 |
| DK Morgan Ltd | Professional & scientific | 2017 |
| DMR Pyro Limited | Other services | 2015 |
| Docs Healthcare Limited | Health & social care | 2020 |
| Doctora Claudia Ltd | Health & social care | 2022 |
| Document Scan Ltd | Information & communication | 2014 |
| Docusoft Limited | Information & communication | 2003 |
| Dog Wash Express Ltd | Other services | 2024 |
| Dolphin Inn Trading Co Ltd | Hospitality | 2023 |
| Dolphin IT Solutions (UK) Ltd | Information & communication | 2008 |
| Dom's Freehold Ltd | Real estate | 2025 |
| Dom's Property Empire Ltd | Real estate | 2020 |
| DON Bailey & SON (Appliance Engineers) Ltd | Manufacturing | 2013 |
| Dopco Limited | Wholesale & retail | 2020 |
| Double Hand Devon Ltd | Hospitality | 2026 |
| DPL Services Ltd | Administrative & support | 2022 |
| Dream Town Devon Ltd | Hospitality | 2025 |
| Drews Motor Co. Limited | Wholesale & retail | 2004 |
| Driftwood (Woolacombe) Ltd | Real estate | 2023 |
| Drone Photography Services Ltd | Information & communication | 2016 |
| Drone School Ltd | Education | 2017 |
| Dryrun Labs Ltd | Information & communication | 2025 |
| DTL100 Ltd | Hospitality | 2021 |
| Ducard Limited | Professional & scientific | 2015 |
| Duck EGG Construction Ltd | Construction | 2022 |
| Duckies Pre-School Ltd | Health & social care | 2019 |
| DUE Diligence Limited | Financial services | 1995 |
| Dunbavand Holdings Ltd | Wholesale & retail | 2026 |
| Dune & Coastal Group Ltd | Professional & scientific | 2026 |
| Dunphy Polymer Ltd | Manufacturing | 2021 |
| Dunphy Technical Services Ltd. | Manufacturing | 2013 |
| DVD Windows Limited | Construction | 2011 |
| DW Solicitors Limited | Professional & scientific | 2013 |
| DX Signs Ltd | Professional & scientific | 2013 |
| Dynamic Heating Ltd | Construction | 2024 |
| E B Clinical Limited | Professional & scientific | 2003 |
| E.A.R. Consultancy Limited | Professional & scientific | 2019 |
| E.Dent Limited | Health & social care | 2010 |
| Eanum Limited | Professional & scientific | 1997 |
| Early Nourishment Community Interest Company | Education | 2018 |
| Earlybirds Day Nursery Limited | Health & social care | 2022 |
| Earth Inspired Ltd | Construction | 2017 |
| Earth Inspired Renewables Ltd | Construction | 2021 |
| Earth Inspired Solar Limited | Construction | 2022 |
| Earth Rebel Ltd | Manufacturing | 2019 |
| East & West Bakery Limited | Wholesale & retail | 2006 |
| East Meadow Management Limited | Households | 2019 |
| East Okewill Farm Ltd | Professional & scientific | 2025 |
| Easterbrook Tractor and Machinery Limited | Manufacturing | 2013 |
| Eclipse Care (Southwest) Ltd | Health & social care | 2017 |
| Eclipse Financial Solutions (SW) Limited | Professional & scientific | 2015 |
| Eclipse Financial Solutions Limited | Extraterritorial | 2005 |
| Eco Green Solar Ltd | Professional & scientific | 2018 |
| Edwards Electrical North Devon Ltd | Construction | 2015 |
| Edwards Plumbing Solutions Ltd | Construction | 2025 |
| EIA Adjudication Services Ltd | Professional & scientific | 2019 |
| EIGHT12 Ltd | Professional & scientific | 2022 |
| EJC Propertyservices Ltd | Professional & scientific | 2022 |
| EK Medical Limited | Health & social care | 2014 |
| Elephant IT Ltd | Information & communication | 2021 |
| Elite Fire Protection South West Ltd | Public administration | 2024 |
| Elite Publications Ltd | Information & communication | 2011 |
| Elite Recovery & Wellness Spa Ltd | Other services | 2025 |
| Elkins Ltd | Real estate | 2025 |
| Ellese Enterprises Limited | Wholesale & retail | 2010 |
| Elmdell Limited | | 1990 |
| Elmhay Communications Ltd | Professional & scientific | 2011 |
| Elvara Ltd | Health & social care | 2025 |
| Elysian Court Management Company (South Molton) Limited | Hospitality | 1996 |
| Emiliani Architects Limited | Professional & scientific | 2026 |
| Emma Hole Limited | Professional & scientific | 2024 |
| Emma Rawicz Music Ltd | Arts & recreation | 2023 |
| Empowering Lives Devon Ltd | Other services | 2025 |
| Encompass Southwest | Health & social care | 2010 |
| Enderley Management Company Limited | Households | 1992 |
| Endsleigh Dental Practices Limited | Health & social care | 2006 |
| Entertainment Rltt Ltd | Hospitality | 2026 |
| Environmental Infrastructure Associates Limited | Professional & scientific | 2000 |
| Envy Game Builders Limited | Professional & scientific | 2016 |
| EPN Fitness Limited | Arts & recreation | 2016 |
| Equi Lane Ltd | Wholesale & retail | 2026 |
| Equibale Limited | Wholesale & retail | 2018 |
| Eren Barber Limited | Other services | 2024 |
| Eriad Digital Solutions Ltd | Information & communication | 2025 |
| ESL Teacher Recruitment Limited | Information & communication | 2024 |
| Essential Mobility Ltd | Wholesale & retail | 2011 |
| Essex Arboriculture Ltd | Agriculture & fishing | 2012 |
| Eurocomp Limited | Information & communication | 2003 |
| European Computer Support Services Limited | Information & communication | 1994 |
| European Tasty Foods Limited | Wholesale & retail | 2025 |
| Evans & Co Accountants & Tax Consultants Ltd. | Professional & scientific | 2003 |
| Evans Heating & Plumbing (SW) Limited | Construction | 2011 |
| Evans Heating & Plumbing Limited | Construction | 2005 |
| Evans Property Management LLP | | 2002 |