| Create Hospitality Limited | Hospitality | 2017 |
| Crick & Co. Limited | Professional & scientific | 1993 |
| CRM Safety Services Ltd | Construction | 2020 |
| Croesy Services Limited | Real estate | 2009 |
| Cross Street Social Ltd | Other services | 2024 |
| Crossfit North Devon Ltd | Arts & recreation | 2012 |
| Crossways Court Management Company Limited | Real estate | 2004 |
| Crsg Limited | Construction | 2019 |
| Cruise Excursions Worldwide Ltd | Administrative & support | 2026 |
| Crydda Property Ltd | Hospitality | 2026 |
| Crystal Light Growth Ltd | Administrative & support | 2025 |
| CSM Wealth Planning Limited | Financial services | 2011 |
| CTC LEY Ltd | Agriculture & fishing | 2003 |
| Cube Create Ltd | Manufacturing | 2023 |
| Curlstone Creatives Limited | Wholesale & retail | 2025 |
| Curry and Spice Ltd | Hospitality | 2025 |
| Curtis Netherway Financial Services Ltd | Financial services | 2016 |
| Curtis Training Associates Limited | Education | 2013 |
| Curtis’S Construction Ltd | Real estate | 2024 |
| Custom Lead Ltd | Manufacturing | 2025 |
| CW Chartered Physiotherapy Ltd | Professional & scientific | 2025 |
| CW Paving & Landscaping Ltd | Administrative & support | 2024 |
| CWH Avonmouth Limited | Construction | 2019 |
| Cwhl Ltd | Construction | 2019 |
| D & G General Builders Ltd | Construction | 2019 |
| D & J MAY Limited | Professional & scientific | 2006 |
| D & R Scott Building Contractors Limited | Construction | 2010 |
| D & S Recovery Limited | Wholesale & retail | 2002 |
| D G S K Holdings Limited | Real estate | 2024 |
| D R Birch Ltd | Real estate | 2024 |
| D S Carpentry & Building Services Limited | Construction | 2003 |
| D Scoff's Ltd | Hospitality | 2025 |
| D&C Entertainments and Events Ltd | Information & communication | 2026 |
| D&F Super Cranes Limited | Administrative & support | 2009 |
| D.J.L.Securities (Barum) Limited | Construction | 1963 |
| D.W.D Construction & Development Ltd | Construction | 2026 |
| DA & SE Ltd | Hospitality | 2025 |
| Daisy Layland Ltd | Real estate | 2022 |
| DAN Maynard’S Fencing Ltd | Administrative & support | 2025 |
| DAN Varley Plumbing & Heating Ltd | Construction | 2014 |
| Dancet Survey Solutions Limited | Professional & scientific | 2013 |
| Darkorchidonline Ltd | Wholesale & retail | 2021 |
| Darren Hearn REB Roofing Services Ltd | Construction | 2019 |
| Dashelmere Ltd | Agriculture & fishing | 2026 |
| Davatka Limited | Wholesale & retail | 2018 |
| David Glover Furniture Limited | Manufacturing | 2013 |
| David J Squire Ltd | Construction | 2003 |
| Davis & Snell (Engineering) Limited | Manufacturing | 1973 |
| DBC Plant Ltd | Other services | 2019 |
| DBS Ltd | Manufacturing | 2009 |
| DE North West Limited | Construction | 2017 |
| Deakin Holdings South West Limited | Financial services | 2020 |
| Decorating&Drylining Solutions Ltd | Construction | 2022 |
| Deepholm Limited | Real estate | 2022 |
| Deer Park (Westward HO) Management Company Limited | Households | 2014 |
| Deflector DC Ltd | Wholesale & retail | 2019 |
| Delicious Kebab Barnstaple Ltd | Hospitality | 2021 |
| Delightful Skin Ltd | Wholesale & retail | 2026 |
| DEM T&A Ltd | Other services | 2026 |
| Denise Bumford Ltd | Professional & scientific | 2003 |
| Dennis Developments (Devon) Limited | Real estate | 2006 |
| Desco Consulting Ltd | Health & social care | 2023 |
| Design Admin Studio Ltd | Professional & scientific | 2026 |
| Design Manage Build (South West) Limited | Construction | 2017 |
| Designlogica Limited | Information & communication | 2021 |
| Destroyer Surfboards Limited | Arts & recreation | 2025 |
| DEV Town Ltd | Information & communication | 2015 |
| Devon & Cornwall DC Power Limited | Manufacturing | 2002 |
| Devon Aircraft Recovery Training Ltd | Education | 2025 |
| Devon and Cornwall Removals Ltd | Transport & logistics | 2024 |
| Devon Antenatal Family Centre CIC | Education | 2018 |
| Devon Barbers Ltd | Other services | 2020 |
| Devon Barbershop Ltd | Other services | 2019 |
| Devon Beach Court Limited | Households | 2001 |
| Devon Buds Garden Design Ltd | Administrative & support | 2022 |
| Devon Building Group Ltd | Construction | 2026 |
| Devon Building Specialists Ltd | Construction | 2022 |
| Devon Building Supplies Limited | Professional & scientific | 1980 |
| Devon Disability Centre Ltd | Health & social care | 2020 |
| Devon Farming Limited | Agriculture & fishing | 2018 |
| Devon Fayre Ltd | Wholesale & retail | 2024 |
| Devon Finance Director LLP | | 2007 |
| Devon Hand Car Wash Ltd | Administrative & support | 2020 |
| Devon Holidays Limited | Real estate | 2019 |
| Devon HP Property Limited | Real estate | 2026 |
| Devon Maides Ltd | Administrative & support | 2018 |
| Devon Nail Salon Limited | Other services | 2021 |
| Devon Pixels Ltd | Professional & scientific | 2016 |
| Devon Science Ltd | Education | 2022 |
| Devon Stairlifts Ltd | Wholesale & retail | 2016 |
| Devon Staycations Limited | Hospitality | 2021 |
| Devon Wood Designs Ltd | Manufacturing | 2008 |
| Devonshire Motors Limited | Wholesale & retail | 1994 |
| Dexter's PB Ltd | Arts & recreation | 2022 |
| Dhilligence Limited | Wholesale & retail | 2019 |
| Diamond Detailing Pro Limited | Wholesale & retail | 2025 |
| Digital Technology UK Limited | Wholesale & retail | 2009 |
| Digitel Technology UK Limited | Wholesale & retail | 2009 |
| Dingles of Devon Ltd | Wholesale & retail | 2023 |
| Dinuma Enterprise Limited | Wholesale & retail | 2023 |