| Starsigned UK Ltd | Wholesale & retail | 2012 |
| Starwhite Holdings Ltd | Financial services | 2021 |
| Starwhite Limited | Hospitality | 2009 |
| Stass Ltd | Wholesale & retail | 2020 |
| Static Solutions Limited | Administrative & support | 2003 |
| Statu Soccer Limited | Information & communication | 2026 |
| Staves Properties Limited | Real estate | 2021 |
| Staycation Motorhomes Ltd | Wholesale & retail | 2020 |
| Staywarm Solid Fuels Ltd | Wholesale & retail | 2006 |
| Steadfast Transport Ltd | Transport & logistics | 2018 |
| Steadyselection Limited | Real estate | 1999 |
| Steel and Stones Laser Removal Ltd | Administrative & support | 2014 |
| Steel and Stones Tattoo Studio Ltd | Wholesale & retail | 2014 |
| Steel City Bespoke Interiors Ltd | Manufacturing | 2024 |
| Steel County Ltd | Water & waste | 2026 |
| Steel Port Ltd | Wholesale & retail | 2016 |
| Steelstruck Limited | | 1985 |
| Steeltek Fabrications Ltd | Manufacturing | 2010 |
| Steeple Chase at Brayton Management Company Limited | Real estate | 2006 |
| Stellar Environmental Consultants Ltd | Professional & scientific | 2012 |
| Stephen Enterprise Ltd | Hospitality | 2026 |
| Stephen HEY Building & Contracting Limited | Construction | 2023 |
| Stephensons IT Support Solutions Ltd | Information & communication | 2020 |
| Steppin' Time School of Dance Ltd | Arts & recreation | 2014 |
| Stepping-Stones-Services Ltd | Health & social care | 2011 |
| Stereo Sanctity Ltd | Information & communication | 2021 |
| Stern & Partner Limited | Administrative & support | 2026 |
| Steve Jones Limited | Wholesale & retail | 2002 |
| Steve Steels Powder Coatings Limited | Manufacturing | 2020 |
| Steve Willis Driving Service Limited | Transport & logistics | 2017 |
| Steve's Steels Engineering Limited | Manufacturing | 2008 |
| Steven Gray Ltd | Professional & scientific | 2023 |
| Stewart Martin & Associates Limited | Professional & scientific | 2019 |
| STG Construction Services Ltd | Construction | 2026 |
| Stickman Crafts Ltd | Manufacturing | 2026 |
| Sticky B'S Syrup Co Ltd | Manufacturing | 2025 |
| Stile 24 Limited | Real estate | 2005 |
| Still Alive PVT Ltd | Hospitality | 2024 |
| Stitch & Stem Ltd | Manufacturing | 2026 |
| Stock Retail Limited | Wholesale & retail | 2021 |
| Stock Sense Ltd | Information & communication | 2022 |
| Stocksbridge Homes Ltd | Construction | 2024 |
| Stockton Group Limited | Real estate | 2021 |
| Stockton's UK (Retail) Ltd | Wholesale & retail | 2021 |
| Stokes International Ltd | Manufacturing | 2015 |
| Stone Checker Software Ltd | Health & social care | 2015 |
| Stonehouse Financial Limited | Financial services | 2016 |
| Stonehouse Travel Limited | Administrative & support | 2019 |
| Stonerow Estates Ltd | Real estate | 2025 |
| Stoney 1971 Limited | Extraterritorial | 2013 |
| Stoneylea Court Management Company Limited | Households | 2023 |
| Stoops Lane Management Company Limited | Real estate | 2004 |
| Store a LOT Ltd | Transport & logistics | 2020 |
| Store Booster Ltd | Manufacturing | 2020 |
| Store FIX Group Limited | Administrative & support | 2020 |
| Storer Property Services Ltd | Real estate | 2026 |
| Storm Commercials Limited | Wholesale & retail | 2012 |
| Stott Telecom and Security Ltd | Information & communication | 2024 |
| STR Property Management Limited | Extraterritorial | 2023 |
| STR8 Path Ltd | Wholesale & retail | 2026 |
| Strada 77 Hairdressing Limited | Other services | 2007 |
| Strada Boutique Hairdressing Limited | Other services | 2022 |
| Strafford Fabrications Limited | Manufacturing | 2010 |
| Strata Flooring Limited | Construction | 2026 |
| Strategic a I Guidance Limited | Information & communication | 2025 |
| Strategic GAS Services Limited | Construction | 2026 |
| Stratford Union Ltd | Hospitality | 2015 |
| Stratwoodengineering Ltd | Professional & scientific | 2025 |
| Strawson Inclinometers Limited | Manufacturing | 2011 |
| Streamline Garages (South Shields) Limited | Professional & scientific | 1946 |
| Strebor Properties Ltd | Real estate | 2024 |
| Strebor Vehicle Services Ltd | Wholesale & retail | 2010 |
| Street Tracks Recordings Ltd | Information & communication | 2015 |
| Street Wise Eats Limited | Wholesale & retail | 2025 |
| Streetwise Defence Training Limited | Education | 2023 |
| Strengths House Limited | Professional & scientific | 2022 |
| Strickland Commercial Ltd | Construction | 2025 |
| Strive Property Limited | Real estate | 2026 |
| Strive Yorkshire Limited | Construction | 2017 |
| Strong Clinic Ltd | Other services | 2025 |
| Student Employment Services (UK) Limited | Administrative & support | 2008 |
| Student Employment Services Holdings Limited | Financial services | 2014 |
| Studio 111 Limited | Arts & recreation | 2017 |
| Studio 97 Barbers Limited | Other services | 2025 |
| Studio Group Training Limited | Other services | 2024 |
| Studio Said Ltd | Professional & scientific | 2022 |
| Stunt Corp Ltd | Information & communication | 2024 |
| Stux Gloves Ltd | Wholesale & retail | 2020 |
| Suba Trading Ltd | Wholesale & retail | 2020 |
| Subituk Limited | Professional & scientific | 2025 |
| Subway Hoyland Ltd | Hospitality | 2020 |
| Successful Accounting Limited | Professional & scientific | 2007 |
| Suicide Sucks CIC | Information & communication | 2024 |
| Sultans Kebab Ltd | Hospitality | 2020 |
| Summer Festival Limited | Arts & recreation | 2019 |
| Summer Lane Fisheries Limited | Hospitality | 2017 |
| Summit Media Limited | Information & communication | 2025 |
| Sumner Development Operations Group Ltd | Information & communication | 2023 |
| Sun City Barnsley Ltd | Other services | 2024 |
| Sun Dental Laboratories (UK) Limited | Manufacturing | 2004 |