| Sun Healthcare Limited | Health & social care | 2001 |
| Sun Inn Monk Bretton Ltd | Hospitality | 2025 |
| Sun Lane Garage (Wakefield) Limited | Wholesale & retail | 2014 |
| Sun MEI Ltd | Hospitality | 2018 |
| Sunny Hearts Ltd | Health & social care | 2024 |
| Sunrise Holidays Ltd | Hospitality | 2019 |
| Sunshine Trading Services Limited | Other services | 2018 |
| Sunthrive Limited | Extraterritorial | 1987 |
| Super Convenience Store Limited | Wholesale & retail | 2023 |
| Superselect Limited | Extraterritorial | 2011 |
| Supportive Steps Youth Services Ltd | Health & social care | 2025 |
| Suppression Systems Support Ltd | Professional & scientific | 2006 |
| Supreme Star Limited | Wholesale & retail | 2025 |
| Sure Healthcare Limited | Health & social care | 2003 |
| SURE4PETS Limited | Other services | 2014 |
| Surfacing Supervisor Ltd | Administrative & support | 2017 |
| Surplus for Good C.I.C. | Wholesale & retail | 2021 |
| Surplus Group Limited | Professional & scientific | 2003 |
| Susan Arblaster Ltd | Other services | 2008 |
| Sustaina Design Engineering Ltd | Manufacturing | 2024 |
| Sustainable Generation Ltd | Administrative & support | 2012 |
| Sutherland Financial Planning Ltd | Financial services | 2023 |
| Svsp Ltd | Health & social care | 2019 |
| Swallow Applications Limited | Extraterritorial | 2008 |
| Swandoor (U.K.) Limited | Extraterritorial | 1993 |
| Swangate Land Limited | Construction | 2016 |
| Swats-On TV Ltd | Information & communication | 2020 |
| Swedish Truck Service Ltd | Wholesale & retail | 2023 |
| Sweet Chanice Limited | Other services | 2012 |
| Sweet Infusions Limited | Wholesale & retail | 2020 |
| Sweet Mania Sweets Ltd | Wholesale & retail | 2022 |
| Swift Building & Joinery Ltd | Construction | 2019 |
| Swift GAS Services (Yorkshire) Ltd | Construction | 2002 |
| Swift Holdings (Barnsley) Limited | Financial services | 2026 |
| Swift Medical Solutions CIC | Administrative & support | 2023 |
| Swift RTA Recovery Ltd | Administrative & support | 2022 |
| Swim to FLY CIC | Arts & recreation | 2025 |
| Swinton Motorcycles (Performance) Limited | Wholesale & retail | 2006 |
| Swipemove Limited | Extraterritorial | 2015 |
| Swiss Guest House Ltd | Hospitality | 2025 |
| Swiss TAP Bar Ltd | Hospitality | 2025 |
| Switched on Accounts Limited | Professional & scientific | 2008 |
| Swombat Limited | Administrative & support | 2023 |
| SWS Sports Ltd | Arts & recreation | 2022 |
| SY Land Developments Ltd | Construction | 2024 |
| Sycare Ltd | Wholesale & retail | 2014 |
| Sykes and Sons Building and Property Ltd | Construction | 2025 |
| Sykes Electrical Limited | Construction | 2007 |
| Sykes Refinishing Yorkshire Limited | Other services | 2023 |
| Sykes Robinson LLP | | 2010 |
| Sykes Robinson Surveyors Limited | Professional & scientific | 2011 |
| Sylvester Industries Limited | | 1986 |
| Sylvo Transport Ltd | Transport & logistics | 2011 |
| Symphony Holdings Limited | Professional & scientific | 2005 |
| Symphony Services Ltd | Construction | 2017 |
| Synergi Ltd | Construction | 2018 |
| Synergy Fitness Group Ltd | Arts & recreation | 2025 |
| Synergy Holdings (Yorkshire) Limited | Financial services | 2015 |
| Synoptique Ltd. | Information & communication | 2016 |
| Syntro Logistics Ltd | Transport & logistics | 2025 |
| Sypc Limited | Health & social care | 2009 |
| T & a Construction Ltd | Construction | 2003 |
| T & a Haulage and Transport Ltd | Transport & logistics | 2022 |
| T & E Designs Ltd | Manufacturing | 2013 |
| T & H Decorators Ltd | Construction | 2024 |
| T & L Property Management Ltd | Real estate | 2022 |
| T Broadhead Health & Safety Services Limited | Administrative & support | 2015 |
| T C Trans Ltd | Transport & logistics | 2025 |
| T Howard Construction (Yorkshire) Ltd | Construction | 2025 |
| T Parchment Window Cleaning Ltd | Administrative & support | 2023 |
| T R and Sons Services Ltd | Manufacturing | 2024 |
| T Retails Ltd | Wholesale & retail | 2026 |
| T S Elle Properties Ltd | Real estate | 2023 |
| T Scargill Ltd | Construction | 2020 |
| T&N Property Investments Ltd | Real estate | 2020 |
| T'Old Filling Station Limited | Wholesale & retail | 2021 |
| T. Lingard & Sons Limited | Construction | 2002 |
| T.F Properties Ltd. | Real estate | 2002 |
| T.I. Garner Limited | Other services | 2009 |
| T.I.E.R. Care Limited | Health & social care | 2010 |
| T.N Healthcare Ltd | Health & social care | 2013 |
| T.T.P. (South Yorkshire) Limited | Wholesale & retail | 2009 |
| T3 Industry Solutions Ltd | Professional & scientific | 2020 |
| T3 Training & Development Ltd | Education | 2016 |
| T5DESIGN Services Limited | Professional & scientific | 2021 |
| T9 Electrical Ltd | Construction | 2025 |
| T97 Global Nexus Ltd | Manufacturing | 2026 |
| TA Transport Solutions Limited | Transport & logistics | 2019 |
| Taag Estates Ltd | Real estate | 2025 |
| Taattoo Beauty Aesthetics Ltd | Other services | 2022 |
| Taattoo Ltd | Administrative & support | 2016 |
| Tabacaru A&M Group Ltd | Transport & logistics | 2026 |
| Tabi and Ngyere Family Ltd | Public administration | 2021 |
| Tabu Bar and Lounge Ltd | Hospitality | 2022 |
| Tache Armega Driving School Ltd | Education | 2022 |
| Tacin Ltd | Real estate | 2024 |
| Tacklefinder Ltd. | Extraterritorial | 2011 |
| Tactical Electrical Services Ltd | Construction | 2026 |
| Tahira Umer Ltd | Wholesale & retail | 2025 |
| Tail Lift Maintenance Limited | Administrative & support | 2008 |