| Spencer Enterprises (Castleford) Limited | Real estate | 1973 |
| Spencer Roofing Services Ltd | Construction | 2019 |
| Spencer's Services Ltd | Wholesale & retail | 2025 |
| Speni Ltd | Wholesale & retail | 2020 |
| Spice 285 Ltd | Hospitality | 2025 |
| Spice Delight Barnsley Ltd | Wholesale & retail | 2024 |
| Spice House Barnsley Limited | Hospitality | 2019 |
| Spicebox Barnsley Limited | Hospitality | 2014 |
| Spiceq Barnsley Ltd | Hospitality | 2025 |
| Spick & Span-Tastic Ltd | Administrative & support | 2025 |
| Spider Magnetics Ltd | Wholesale & retail | 2012 |
| Spiral City Limited | Hospitality | 2021 |
| Spirits and Crafts (Barnsley) Limited | Wholesale & retail | 2025 |
| SPK Imaging Limited | Health & social care | 2023 |
| SPK Properties Limited | Real estate | 2017 |
| Splash Swim Academy Featherstone Limited | Education | 2015 |
| Splash to Swim School Ltd | Arts & recreation | 2022 |
| Splinter Sound Ltd | Arts & recreation | 2020 |
| Spodden Park Ltd | Real estate | 2020 |
| Spontaneous Entertainment Ltd | Hospitality | 2023 |
| Spoon Cereals UK Ltd | Manufacturing | 2013 |
| Sport Elevation Ltd | Education | 2014 |
| Sportax Consultancy Limited | Professional & scientific | 2026 |
| Spot Cleaners Ltd | Administrative & support | 2025 |
| Spphysiques Ltd | Arts & recreation | 2022 |
| Spproperty Lets Ltd | Real estate | 2022 |
| Sprakes and Johnson Catering Limited | Hospitality | 2021 |
| Spratt Media Ltd | Other services | 2019 |
| Sprayed Limited | Wholesale & retail | 2013 |
| Sprillers | Administrative & support | 2015 |
| Spring Ahead C.I.C. | Education | 2017 |
| Springchoice Bar Ltd | Real estate | 2026 |
| Springchoice Holdings Limited | Professional & scientific | 1978 |
| Springchoice Leisure Limited | Other services | 1991 |
| Springchoice Properties Limited | Real estate | 2016 |
| Springfield Meadows Properties Limited | Real estate | 2026 |
| Springwood (Barnsley) Management Company Limited | Households | 2003 |
| Sprint Renewables Limited | Construction | 2020 |
| Sprint Swim Academy Limited | Arts & recreation | 2022 |
| SPS Motorcycles Ltd | Wholesale & retail | 2019 |
| Spsas Valeting Ltd | Administrative & support | 2026 |
| SPV Property Management Ltd | Real estate | 2015 |
| Sqgd Real Estate Limited | Construction | 2014 |
| Squadbox Training Limited | Arts & recreation | 2020 |
| Square Paraplanning Ltd | Financial services | 2021 |
| Square Triangle Services Limited | Other services | 2018 |
| SR (Yorkshire) Limited | Wholesale & retail | 2024 |
| SR Building Services Consultants Ltd | Professional & scientific | 2025 |
| SR Holdings Yorkshire Ltd | Agriculture & fishing | 2025 |
| SR Property Maintenance and Cleaning Services Ltd | Construction | 2025 |
| SR Pubco Ltd | Hospitality | 2022 |
| SRA Gaming Limited | Arts & recreation | 2025 |
| SRB Fisheries Ltd | Hospitality | 2021 |
| Srehab Limited | Administrative & support | 2017 |
| SRG Property Consultants Ltd | Construction | 2010 |
| SRG Renovations Ltd | Construction | 2020 |
| SRH Plastering Ltd | Construction | 2019 |
| SRH Propertys Investment Ltd | Real estate | 2020 |
| SRL Electrical Solutions Limited | Construction | 2022 |
| SRS Automotive Limited | Wholesale & retail | 2011 |
| SS Haulage Services Ltd | Transport & logistics | 2025 |
| SS Workforce Innovation Ltd | Professional & scientific | 2025 |
| SS Worktops Limited | Construction | 2022 |
| Ssaa Fried Chicken Ltd | Hospitality | 2025 |
| SSL Direct Mail and Print Limited | Manufacturing | 2015 |
| SSM Lettings Ltd | Real estate | 2022 |
| SSR Support Ltd | Real estate | 2024 |
| ST Georges Park at Rothwell Management Limited | Real estate | 2004 |
| ST Helier Homes Limited | Construction | 2021 |
| ST James's Group Limited | Administrative & support | 1998 |
| ST Lawrence Court (Mansfield) Management Company Limited | Households | 1994 |
| ST Mary's Academy Trust | Education | 2012 |
| ST Nicholas Properties Limited | Real estate | 1997 |
| ST Private Healthcare Ltd | Financial services | 2017 |
| ST Wilfrids Walk Management Company Limited | Households | 2017 |
| ST. Catherines Mews at Balby Property Management Company Limited | Professional & scientific | 2003 |
| Stacey Shaw Hairdressing Limited | Other services | 2018 |
| Staff&You Ltd | Professional & scientific | 2023 |
| Staffordshire Maintenance Services Ltd | Construction | 2000 |
| Stage Circuit Ltd | Arts & recreation | 2026 |
| Stage Door Limited | Hospitality | 2017 |
| Stage MCR Limited | Hospitality | 2018 |
| Stainborough Close 1961 Limited | Extraterritorial | 2014 |
| Stainborough Road 1962 Limited | Extraterritorial | 2014 |
| Staincross Carpets Ltd | Wholesale & retail | 2010 |
| Stairfoot Metals Limited | Wholesale & retail | 2016 |
| Stairfoot MOT Centre Limited | Wholesale & retail | 2007 |
| Stairfoot Valeting Limited | Extraterritorial | 2016 |
| Stalagmite Developments Limited | Real estate | 2004 |
| Staleys Tree Solutions Ltd | Administrative & support | 2022 |
| Stamford Land Ltd | Agriculture & fishing | 2007 |
| Stancepurpose Property Management Limited | Real estate | 1997 |
| Standis Group Limited | Construction | 2015 |
| Standring Brown Health Ltd | Health & social care | 2022 |
| Star Autocentre Ltd | Wholesale & retail | 2024 |
| Star Barber Shop Yorkshire Ltd | Other services | 2021 |
| Starhevan Landscapes Ltd | Professional & scientific | 2026 |
| Starlight Blinds Ltd | Manufacturing | 2003 |
| Starport Express Ltd | Transport & logistics | 2022 |
| Stars Logistics Ltd | Transport & logistics | 2026 |