| SML Entertainment Ltd | Hospitality | 2023 |
| Smooth Movement Limited | Transport & logistics | 2019 |
| SMS Machine Automation Holdings Limited | Financial services | 2019 |
| SMS Machine Automation Limited | Manufacturing | 2000 |
| Snack Break Ltd | Wholesale & retail | 2012 |
| Snape Hill Garage Limited | Wholesale & retail | 2012 |
| Snape Hill Road Garage Limited | Wholesale & retail | 2026 |
| Snappies Photoprocessing Laboratory Limited | Professional & scientific | 1990 |
| SNC Transport & Business Services Ltd | Transport & logistics | 2026 |
| Snowcademy Ltd | Extraterritorial | 2010 |
| SNS Building and Joinery Limited | Construction | 2025 |
| SNS Construction Services Ltd | Construction | 2021 |
| Snuggle Living Ltd | Real estate | 2022 |
| Soar Future Holdings Limited | Water & waste | 2024 |
| Sobaka Holdings Ltd | Financial services | 2021 |
| Social Media Fairy Limited | Extraterritorial | 2025 |
| Socialista Limited | Information & communication | 2017 |
| Soda SU Limited | Wholesale & retail | 2025 |
| Soft Touch Homes Limited | Real estate | 2023 |
| Softcom Solutions (UK) Ltd | Information & communication | 2002 |
| Sohaila & Saja Gynaecological Services Limited | Health & social care | 2025 |
| Solar Battery Energy EV Store Ltd | Construction | 2020 |
| Solar Energy Group Ltd | Construction | 2022 |
| Solar Energy Investments Ltd | Financial services | 2024 |
| Solara Cleaning Ltd | Administrative & support | 2012 |
| Solarized Limited | Construction | 2023 |
| Solec Engineering Ltd | Professional & scientific | 2011 |
| Solid Design Services Limited | Administrative & support | 2009 |
| Solid Fuel Solutions Limited | Construction | 2025 |
| Solidcam U.K. Ltd | Information & communication | 1999 |
| Solidor Limited | Manufacturing | 2005 |
| Soltek Solutions Ltd | Construction | 2024 |
| Solution 3 Ltd | Other services | 2022 |
| Sonelli Hair & Beauty Trading Co Ltd | Other services | 2008 |
| Sonic Impact Music Limited | Information & communication | 2013 |
| Sonic Taverns Limited | Hospitality | 2024 |
| Sorby Foods Ltd | Wholesale & retail | 2025 |
| Sorbys Limited | Real estate | 2008 |
| Sorek Ltd | Information & communication | 2023 |
| Sorted Performance Alloy Wheels Limited | Wholesale & retail | 2024 |
| SOS GAS Services Limited | Construction | 2011 |
| Soteria Compliance Limited | Professional & scientific | 2019 |
| Soul of Margaux Ltd | Wholesale & retail | 2026 |
| Soul/Town Ltd | Hospitality | 2019 |
| Soundless Developments Limited | Real estate | 2002 |
| Soundproof Materials Ltd | Wholesale & retail | 2021 |
| Sourced by ASH Ltd | Wholesale & retail | 2025 |
| South Haven Whitby Limited | Financial services | 2020 |
| South Yorkshire 4X4 Ltd | Professional & scientific | 2026 |
| South Yorkshire Aggregates Reclamation Ltd | Wholesale & retail | 2025 |
| South Yorkshire Civil Engineering Limited | Wholesale & retail | 1981 |
| South Yorkshire Colleges Group Limited | Education | 2026 |
| South Yorkshire Crushing Limited | Construction | 2018 |
| South Yorkshire Darts Ltd | Wholesale & retail | 2025 |
| South Yorkshire Data Solutions Limited | Construction | 2019 |
| South Yorkshire Drilling Company Ltd | Construction | 2014 |
| South Yorkshire Electric Bike Centre Limited | Wholesale & retail | 2012 |
| South Yorkshire Group Limited | Real estate | 1998 |
| South Yorkshire Holdings Ltd | Extraterritorial | 2020 |
| South Yorkshire Homes Limited | Real estate | 2018 |
| South Yorkshire Investment Capital Fund Ltd. | Financial services | 2001 |
| South Yorkshire Investment Development Fund Ltd. | Financial services | 2001 |
| South Yorkshire Investment Fund Limited | Financial services | 2000 |
| South Yorkshire Investment Small Business Fund Limited | Financial services | 2001 |
| South Yorkshire Knotweed Control Ltd | Administrative & support | 2019 |
| South Yorkshire Plant and Drilling Equipment Hire Limited | Construction | 2023 |
| South Yorkshire Shooting Supplies Limited | Arts & recreation | 2003 |
| Southfield Touring & Tent Park Ltd | Hospitality | 2021 |
| Southmoor Grange (Management) Company Limited | Households | 2005 |
| Southside Hallam Properties Limited | Construction | 2016 |
| Sovereign Building & Roofing Specialist Limited | Construction | 2017 |
| Sovereign Care Solutions Ltd | Health & social care | 2020 |
| Sovo Holdings Ltd | Real estate | 2025 |
| SP Pack UK Limited | Manufacturing | 2026 |
| SP Renovations Ltd | Real estate | 2026 |
| Spa Mill Management Company Limited | Professional & scientific | 2006 |
| Spank IT Ltd | Wholesale & retail | 2023 |
| Spark Electrical (Yorkshire) Limited | Construction | 2025 |
| Sparkeling Valeting Ltd | Administrative & support | 2026 |
| Sparkling Valeting Centre Limited | Administrative & support | 2024 |
| Spartan Lifestyle Ltd | Arts & recreation | 2020 |
| Spartans Same Day Ltd | Transport & logistics | 2020 |
| Spdl Limited | Construction | 2014 |
| Spear & Jackson International Limited | Manufacturing | 1951 |
| Specialised Aerosols Company Limited | Manufacturing | 1977 |
| Specialised Laser Products Limited | Manufacturing | 1995 |
| Specialised Tanker Services Limited | Other services | 1980 |
| Specialised Truck Services Limited | Wholesale & retail | 2015 |
| Specialist Civils UK Ltd | Other services | 2018 |
| Specialist Lighting SS Limited | Construction | 2008 |
| Specialist Vehicle Services Ltd | Manufacturing | 2019 |
| Spectra Care Ltd | Health & social care | 2019 |
| Spectrum GLO Solutions Ltd | Information & communication | 2026 |
| Spectrum Hosting Limited | Information & communication | 2021 |
| Spedding Limited | Real estate | 2009 |
| Speed Butchers Ltd | Wholesale & retail | 2015 |
| Speed Deck (Yorkshire) Ltd | Administrative & support | 2024 |
| Speed Driver Garage Ltd | Wholesale & retail | 2022 |
| Speedy Crete Ltd | Manufacturing | 2023 |
| Speight Strength Events Limited | Hospitality | 2024 |