| SBU Utilities Limited | Construction | 2025 |
| SC & PJ Densley Limited | Professional & scientific | 2003 |
| SC Cladding UK Ltd | Construction | 2023 |
| SC Master Limited | Professional & scientific | 2021 |
| SC Sweet Confections Ltd | Wholesale & retail | 2025 |
| Scaff Bitz Ltd | Construction | 2026 |
| Scaffsafe Ltd | Public administration | 2019 |
| Scaife Properties Ltd | Hospitality | 2023 |
| Scalby Investments | Financial services | 2025 |
| Scale Tech Talent Limited | Professional & scientific | 2018 |
| Scalo Consultancy Limited | Information & communication | 2024 |
| Scalp Pro Clinic Barnsley Ltd | Professional & scientific | 2025 |
| Scape Nouveau Consult Global Limited | Real estate | 2024 |
| Scapegrace Distilling Co. Europe Limited | Manufacturing | 2020 |
| Scenic Bandwagon Limited | Arts & recreation | 2018 |
| Scholey Developments Ltd | Real estate | 2025 |
| School Court Apartments Management Company Limited | Real estate | 2004 |
| School House Venue Ltd | Hospitality | 2016 |
| Schwarz Spedition Ltd | Transport & logistics | 2025 |
| Scils Management Centre Limited | Education | 2023 |
| Scorpho Limited | Financial services | 2001 |
| Scorpion Construction (UK) Limited | Construction | 2021 |
| Scorpion Property Investments Ltd | Real estate | 2025 |
| Scorpioway Logistics Ltd | Transport & logistics | 2026 |
| Scotcon Limited | Real estate | 2015 |
| Scott Property Group Limited | Real estate | 2025 |
| Scott Wilson Traffic Ltd | Construction | 2023 |
| Screen 4 LLP | | 2009 |
| Screen Printing Association (UK) Limited | Other services | 1949 |
| SCREEN4 Holdings Limited | Financial services | 2021 |
| Scribblers INK Ltd | Extraterritorial | 2002 |
| Script Publisher Services Limited | Information & communication | 2024 |
| Scrumfall Limited | Professional & scientific | 2024 |
| Scuderia Car Parts Ltd | Wholesale & retail | 2002 |
| Scuderia Tuning Parts Ltd | Wholesale & retail | 2009 |
| Scvgn Ltd. | Information & communication | 2020 |
| SDH Properties (Yorkshire) Ltd | Real estate | 2024 |
| Sdkd Holdings Limited | Financial services | 2019 |
| SDL Management Solutions Ltd | Professional & scientific | 2026 |
| Sea Birds Ltd | Wholesale & retail | 2013 |
| Sea Birds Wombwell Limited | Hospitality | 2014 |
| Sea Scooter UK Limited | Wholesale & retail | 2010 |
| Sealquest Limited | Construction | 2002 |
| Sealquest Properties Limited | Real estate | 2007 |
| Seaman & Keys Ltd | Financial services | 2023 |
| Seazons UK Home & Gardens Ltd | Wholesale & retail | 2025 |
| Secmo Ltd | Administrative & support | 2024 |
| Secure Edge Access Limited | Extraterritorial | 2007 |
| Secure Solutions Group Limited | Transport & logistics | 2017 |
| Securitec (Yorkshire) Ltd | Administrative & support | 2016 |
| Securitec Services Ltd | Administrative & support | 2025 |
| Securtask Limited | Professional & scientific | 2006 |
| Seddon Brickwork Ltd | Construction | 2022 |
| Seductive Secret Limited | Other services | 2025 |
| Seed Hair Limited | Other services | 2019 |
| Seeking Spirit Events Limited | Professional & scientific | 2014 |
| Sefton Property Group Limited | Real estate | 2021 |
| Segilane Limited | Health & social care | 2025 |
| SEI Chung SAK Ltd | Health & social care | 2014 |
| Seichou Media Ltd | Professional & scientific | 2023 |
| Sejdorfo Limited | Wholesale & retail | 2015 |
| Sejdorfo Properties Limited | Real estate | 2021 |
| Select Electrical & Building Services Ltd | Construction | 2011 |
| Select Group (Yorkshire) Holdings Limited | Financial services | 2019 |
| Select Systems Limited | Manufacturing | 2003 |
| Self Store Solutions Limited | Transport & logistics | 2007 |
| Selfsure Estate Planning Ltd | Other services | 2018 |
| Sellf CIC | Education | 2025 |
| Sellius Ltd | Wholesale & retail | 2022 |
| Selltech Partners Limited | Administrative & support | 2025 |
| Selvi Healthcare Limited | Health & social care | 2025 |
| SEN Medical Ltd | Health & social care | 2022 |
| Senior and Senior Property and Lettings Limited | Real estate | 2025 |
| Senior Dating Agency Limited | Professional & scientific | 2011 |
| Senior Haulage Limited | Transport & logistics | 2002 |
| Senior Render Specialist Limited | Construction | 2019 |
| Seniors Property and Lettings Ltd | Real estate | 2025 |
| Sense Technologies Ltd | Information & communication | 2025 |
| Sentinel Door Systems Ltd | Manufacturing | 2005 |
| SEREN24 Care Ltd | Health & social care | 2020 |
| Serenia Spa Ltd | Hospitality | 2006 |
| Serenity Property Developments Ltd | Construction | 2024 |
| Serenus Health Limited | Information & communication | 2025 |
| Service Plus Auto Centre Limited | Wholesale & retail | 2011 |
| Services UN Limited | Information & communication | 2022 |
| Setay Homes (Willow Grove) Ltd | Construction | 2023 |
| Setay Homes Limited | Construction | 2023 |
| Sets for Life Limited | Construction | 2025 |
| Seunbentleyk Services Ltd | Health & social care | 2023 |
| Seven Seventeen PVT Ltd | Wholesale & retail | 2024 |
| Seven Sons External Designs Limited | Professional & scientific | 2025 |
| SEW Embroidery Limited | Other services | 2011 |
| Sexy Hair 1 Ltd | Other services | 2009 |
| SF Locksmith Ltd | Manufacturing | 2013 |
| SF Parts Limited | Wholesale & retail | 2017 |
| SF Project Management Ltd | Construction | 2023 |
| SF UAV Services Ltd | Professional & scientific | 2025 |
| SG Barnsley Limited | Hospitality | 2025 |
| SG Work Force Ltd | Transport & logistics | 2025 |
| SG90 Ltd | Transport & logistics | 2022 |