| SGB Plant Operator Services Limited | Administrative & support | 2023 |
| SGL Scaffolding Ltd | Construction | 2024 |
| SGP Refrigeration Limited | Other services | 2004 |
| Sgpm International Ltd | Professional & scientific | 2012 |
| SGS Care Ltd | Administrative & support | 2023 |
| SH Contracts Ltd | Construction | 2025 |
| SH Groundworks & Plant Hire Limited | Other services | 2021 |
| SH Whitby Holiday Apartment Limited | Real estate | 2024 |
| SHA Shawarma Ltd | Hospitality | 2019 |
| Shade Hair & Beauty Ltd | Other services | 2025 |
| Shafton Estates Limited | Construction | 2026 |
| Shafton Steel Limited | Manufacturing | 2015 |
| Shafton Steel Services Limited | Manufacturing | 2015 |
| Shake N Cake Ltd | Hospitality | 2019 |
| Share Co Holdings Limited | Construction | 2024 |
| Sharp Travel Ltd | Transport & logistics | 2019 |
| Shaun Beaumont Limited | Administrative & support | 2004 |
| Shaun LAX Financial Consulting Ltd | Financial services | 2006 |
| Shaun Tonge Engineering Limited | Other services | 2016 |
| Shaw C Limited | Wholesale & retail | 2018 |
| Shaw Construction Barnsley Ltd | Construction | 2019 |
| Shayush Retail Ltd | Wholesale & retail | 2023 |
| Shazam Finance Limited | Financial services | 2015 |
| Shbp Ltd | Wholesale & retail | 2026 |
| Sheaf Engineering Properties Limited | Construction | 2026 |
| Shearcut Engineering Limited | Manufacturing | 2000 |
| Shearon Decor Ltd | Construction | 2020 |
| Sheehan Improvements Ltd | Construction | 2022 |
| Sheffield Flat Roofing Ltd | Construction | 2023 |
| Sheffield North Senior Care Services Limited | Health & social care | 2015 |
| Sheffield Property Renovations Ltd | Construction | 2019 |
| Sheffield South Senior Care Services Limited | Health & social care | 2015 |
| Sheffix Limited | Administrative & support | 2002 |
| Shekinah Muddy Paws Ltd | Other services | 2023 |
| Shelbarr Transport Ltd | Transport & logistics | 2025 |
| Sheldale Developments Limited | Construction | 1991 |
| Shelley Steels Associates Limited | Financial services | 2013 |
| Shelleyseward Limited | Health & social care | 2025 |
| Shelton's Bakery Limited | Wholesale & retail | 2025 |
| Shemeld Joinery Limited | Construction | 2026 |
| Sherwood Joinery Limited | Construction | 2025 |
| Sheryll Hamshaw Ltd | Extraterritorial | 2024 |
| Shields Property Solutions Limited | Real estate | 2020 |
| Shift Retail Limited | Professional & scientific | 2019 |
| Shikenah Healthcare Ltd | Extraterritorial | 2023 |
| Shimszu Japanese Restaurant Ltd | Hospitality | 2024 |
| Shinny Solutions Cleaning Ltd | Administrative & support | 2024 |
| Shiny Pistons Ltd | Wholesale & retail | 2023 |
| Shirehill Properties Limited | Real estate | 1996 |
| Shireoaks Business Centre Limited | Extraterritorial | 2020 |
| Shirewood Plumbing & Heating Limited | Construction | 2015 |
| Shirom (UK) Limited | Wholesale & retail | 1998 |
| Shirt Conor Ltd | Manufacturing | 2026 |
| Shivom Yorkshire Ltd | Wholesale & retail | 2026 |
| Shivshaktii Enterprise Ltd | Transport & logistics | 2025 |
| Shravan Food & Wine Ltd | Wholesale & retail | 2022 |
| Shravans Propeties Ltd | Real estate | 2024 |
| Shufflebottom Properties Limited | Real estate | 2023 |
| Shuttercraft West Yorkshire Limited | Wholesale & retail | 2015 |
| Sibanda Ltd | Health & social care | 2018 |
| Sibora Ltd | Hospitality | 2025 |
| SID Tyas (Confectionery) | | 1986 |
| Sidcon Ltd | Transport & logistics | 2018 |
| Siddall's Renovations Ltd | Construction | 2024 |
| Sigma 786 Limited | Wholesale & retail | 2018 |
| Sigma Kitchens & Joinery Limited | Construction | 2024 |
| Sigma Services & Solutions Limited | Construction | 2009 |
| Sigma Solid Surfaces Ltd | Construction | 2019 |
| Signalsighting.Com Ltd | Other services | 2022 |
| Signature Dress Limited | Wholesale & retail | 2023 |
| Signature Scents Co Ltd | Manufacturing | 2026 |
| Signs Xtra Ltd | Administrative & support | 2000 |
| Silandulo Services Ltd | Health & social care | 2018 |
| Silhouettes Ab&T Turnkey Limited | Professional & scientific | 2012 |
| Silk Mary Ltd | Wholesale & retail | 2024 |
| Silkstone Consultants Limited | Financial services | 2018 |
| Silkstone Enterprises Ltd | Professional & scientific | 2024 |
| Silkstone Golf Club Limited | Arts & recreation | 2022 |
| Silkstone Living Ltd | Real estate | 2022 |
| Silkstone Property Investments Limited | Construction | 2009 |
| Silva Cloud Limited | Agriculture & fishing | 2014 |
| Silva Services Supply Limited | Other services | 2020 |
| Silver Birch Labs Limited | Information & communication | 2025 |
| SIM City Ltd | Arts & recreation | 2026 |
| Simba Secure Care Services Limited | Public administration | 2018 |
| Simon Law & SON (Plumbing & Heating) Ltd | Construction | 2015 |
| Simon Speight Services Ltd | Manufacturing | 2018 |
| Simple Living Eco Ltd | Manufacturing | 2021 |
| Simple Living Eco Wholesale Limited | Wholesale & retail | 2024 |
| Simple Luxury Limited | Wholesale & retail | 2013 |
| Simple Render Solution 4 U Ltd | Wholesale & retail | 2019 |
| Simplymels Ltd | Health & social care | 2022 |
| Simpson Boxing Limited | Arts & recreation | 2022 |
| Simpson Investments Ltd | Real estate | 2026 |
| Sims Pharma Ltd | Wholesale & retail | 2024 |
| Singhs Elsecar Ltd | Wholesale & retail | 2020 |
| Sipdave Logistics Ltd | Transport & logistics | 2024 |
| Siptrek Ltd | Wholesale & retail | 2025 |
| SIR Edmund Limited | Transport & logistics | 2023 |
| Siren Technology Ltd | Information & communication | 2003 |