| S&H Beauty Limited | Other services | 2023 |
| S&M Thomas Properties Ltd | Real estate | 2025 |
| S&Rg Property Limited | Real estate | 2024 |
| S&S Cable Jointing Ltd | Energy | 2019 |
| S&S Roofline Limited | Manufacturing | 2019 |
| S&Z Ltd | Wholesale & retail | 2018 |
| S. Anwar Associates Limited | Professional & scientific | 2012 |
| S. K. Watson Limited | Professional & scientific | 2010 |
| S. T. Electrical Services Ltd | Construction | 2008 |
| S.D. Nugent Joinery & Construction Ltd | Construction | 2011 |
| S.D. Parr & Company Limited | Manufacturing | 1980 |
| S.F. Booth Developments Limited | Other services | 2016 |
| S.G.S Group (Barnsley) Ltd | Construction | 2010 |
| S.J. Electrical (Yorkshire) Limited | Construction | 2019 |
| S.M.A.T. Construction Ltd | Construction | 2017 |
| S.N Group Holdings Ltd | Financial services | 2026 |
| S.Riches Plumbing & Heating Ltd | Construction | 2022 |
| S1E Limited | Manufacturing | 2017 |
| S2 Ventures Holdings (Yorkshire) Limited | Financial services | 2025 |
| S21 Developments Limited | Construction | 2025 |
| S63VAGSPARES Ltd | Wholesale & retail | 2024 |
| S70MEDIA Ltd | Professional & scientific | 2023 |
| S75 Property Ltd | Real estate | 2024 |
| S7FIVE Ltd | Construction | 2023 |
| SA OPS Ltd | Hospitality | 2024 |
| SA Stay Ltd | Hospitality | 2022 |
| SA26 Ltd | Professional & scientific | 2022 |
| SAA Fried Chicken Ltd | Hospitality | 2023 |
| Sabah Pizza Ltd | Hospitality | 2024 |
| Sabby Hub Ltd | Wholesale & retail | 2026 |
| Sabur Digital Limited | Wholesale & retail | 2014 |
| Sabur INK Systems Ltd. | Wholesale & retail | 1998 |
| Saddlebred Forge Limited | Professional & scientific | 2003 |
| Saeed Alam Limited | Health & social care | 2024 |
| Safe Base Fostering Limited | Health & social care | 2015 |
| Safe Base Hub C.I.C. | Other services | 2019 |
| Safe Card Limited | Manufacturing | 2023 |
| Safe Ways Care Solutions Ltd | Health & social care | 2025 |
| Safeguard Innovations Ltd | Professional & scientific | 2026 |
| Safeguarding Children Training and Consultancy Limited | Professional & scientific | 2013 |
| Safehand Consulting Limited | Information & communication | 2016 |
| Safehouse Health and Safety Consultants Ltd | Administrative & support | 2015 |
| Safety Ramps UK Limited | Construction | 2008 |
| Saffron Cuisine Limited | Hospitality | 2024 |
| SAG Professional Services Limited | Professional & scientific | 2017 |
| SAG Property Services Limited | Real estate | 2019 |
| Sagar Mcclintock Limited | Administrative & support | 2009 |
| Sagittarius Investment Holdings Ltd | Financial services | 2018 |
| Sagm Ltd | Water & waste | 2021 |
| Saint Paul's Walk Management Company Limited | Professional & scientific | 2005 |
| Saladin Labs Limited | Professional & scientific | 2025 |
| Sales Support Ltd | Real estate | 2020 |
| Salibura Ltd | Wholesale & retail | 2020 |
| SALMON3 Limited | Professional & scientific | 2020 |
| Salon Trade Connections Ltd | Wholesale & retail | 2021 |
| Salost Staffing Solutions Ltd | Administrative & support | 2020 |
| Salt & Pepper Polish Restaurant Limited | Hospitality | 2021 |
| Saltbrook Properties Limited | Real estate | 2024 |
| Saltlake Property Limited | Real estate | 2023 |
| SAM Poskitt Personal Training Ltd | Other services | 2024 |
| SAM Transport Services Ltd | Transport & logistics | 2016 |
| SAM Warner Consulting Limited | Health & social care | 2009 |
| Sam's Corner Shop Ltd | Wholesale & retail | 2025 |
| Samaz Properties Ltd | Real estate | 2025 |
| Samegia Ltd | Wholesale & retail | 2025 |
| Sanbert Limited | Health & social care | 2020 |
| Sanchez Fast Food Limited | Hospitality | 2025 |
| Sanctuary Health & Wellbeing Limited | Arts & recreation | 2016 |
| Sand and Sky Ltd | Health & social care | 2024 |
| Sanders Transport Ltd | Transport & logistics | 2018 |
| Sandersgill Ltd | Manufacturing | 2024 |
| Sanderson Apparel Ltd | Wholesale & retail | 2026 |
| Sandhill Golf Club Limited | Arts & recreation | 1991 |
| Sandoria Limited | Administrative & support | 2017 |
| Sangha Retail Limited | Wholesale & retail | 2011 |
| Sanota Health Limited | Health & social care | 2019 |
| Santorini Restaurant&Takeaway Ltd | Hospitality | 2022 |
| Sapoflow Limited | Construction | 1992 |
| Sapphire Construct Limited | Water & waste | 2025 |
| Sapphire Management Company Limited | Households | 2006 |
| Sarah Burns Prints Limited | Manufacturing | 2018 |
| Sarah Colton Permanent Cosmetics Ltd | Other services | 2012 |
| Sarah Moore Case Management Ltd | Professional & scientific | 2026 |
| Sarchiz Limited | Health & social care | 2016 |
| Sarg Properties Limited | Real estate | 2024 |
| Sarmasan Connection Ltd | Transport & logistics | 2023 |
| SAS - Safe Access Scaffolding Ltd | Construction | 2025 |
| SAS Business Solutions Limited | Professional & scientific | 2016 |
| SAS GAS Limited | Construction | 2020 |
| SAS Renovations & Developments Ltd | Construction | 2019 |
| Sasha Global Ltd | Wholesale & retail | 2024 |
| Satisfy Limited | Arts & recreation | 2026 |
| Sauk Holdings Limited | Financial services | 2025 |
| Sauk Utilities Limited | Construction | 2012 |
| Saul Construction Limited | Construction | 1973 |
| Sawmill (Penistone) Management Company Limited | Households | 2015 |
| SB Landscapes Limited | Administrative & support | 2018 |
| SB Nova Limited | Professional & scientific | 2025 |
| SB Parts Ltd | Wholesale & retail | 2026 |
| SB South Yorkshire Development Ltd | Construction | 2026 |