| Salcroft Limited | Wholesale & retail | 2021 |
| Saleem & Co Solicitors Ltd | Professional & scientific | 2025 |
| Salemono Ltd | Transport & logistics | 2025 |
| Salim's & Co UK Ltd | Wholesale & retail | 2019 |
| Salina Fruit & VEG Ltd | Wholesale & retail | 2024 |
| Salmik Creations Ltd | Wholesale & retail | 2022 |
| Salt Valley Ltd | Construction | 2020 |
| Saluna Cons Transport and Logistic Limited | Construction | 2019 |
| Salvatore 1978 Limited | Other services | 2015 |
| SAM and Samantha Limited | Health & social care | 2017 |
| Samange Technical Global Resources Limited | Construction | 2014 |
| Samatos Limited | Information & communication | 2018 |
| Samcon Motoring Limited | Education | 2020 |
| Samence Limited | Wholesale & retail | 2022 |
| Samiehealthcare Ltd | Health & social care | 2021 |
| Samihah Ltd | Hospitality | 2018 |
| SAMINI5 Tuition Ltd | Education | 2017 |
| Samkyi Limited | Transport & logistics | 2025 |
| Sammic Logistics Ltd | Transport & logistics | 2024 |
| Samola Industries Limited | Manufacturing | 2017 |
| Samosa Haus Ltd | Wholesale & retail | 2023 |
| Samren Care Limited | Public administration | 2018 |
| Sams Fast Foods Limited | Wholesale & retail | 2005 |
| Sams Superstore Ltd | Wholesale & retail | 2024 |
| Samuel Slattery Ltd | Professional & scientific | 2023 |
| Samy Builders Ltd | Construction | 2025 |
| SAN Pest UK Ltd | Agriculture & fishing | 2026 |
| SAN Property Limited | Real estate | 2025 |
| Sanaaz Hospitality Group Ltd | Manufacturing | 2026 |
| Sanabil After School Club Ltd | Education | 2025 |
| Sandhu Build UK Limited | Construction | 2021 |
| Sangamar Cleaning Ltd | Administrative & support | 2021 |
| Sangha Group Holdings Ltd | Real estate | 2025 |
| Sangnaa Limited | Construction | 2015 |
| Sanguine Scissors Limited | Wholesale & retail | 2009 |
| Santers Solicitors Limited | Professional & scientific | 2022 |
| Santorello Ltd | Wholesale & retail | 2025 |
| Sanzi Trans Ltd | Transport & logistics | 2017 |
| SAP Construct Ltd | Manufacturing | 2020 |
| Saper Glass Industries Limited | Construction | 1987 |
| Saper Longreach Limited | Real estate | 2014 |
| Sapphire Fertilizers Co Limited | Wholesale & retail | 2021 |
| Sara & Bros Ltd | Real estate | 2021 |
| Sara International Consultants Limited | Education | 2025 |
| Sarat Cleaning Services Ltd | Administrative & support | 2025 |
| Sarat Healthcare Ltd | Administrative & support | 2020 |
| Sardar Security Group Ltd | Administrative & support | 2026 |
| Sarp Kitchen Limited | Hospitality | 2025 |
| Sartoria Diamante Ltd | Wholesale & retail | 2024 |
| Sarwar Alam Ltd | Information & communication | 2016 |
| SAS Services Essex Ltd | Transport & logistics | 2015 |
| Sasa Homes Limited | Health & social care | 2016 |
| Sasa Kitchen Ltd | Hospitality | 2025 |
| Sasa Solutions Ltd | Manufacturing | 2021 |
| Sash Windows Profesional Limited | Construction | 2018 |
| SAT RAQ Limited | Real estate | 2016 |
| Satisfied Ltd | Real estate | 2018 |
| Satti Online Distributors Ltd | Wholesale & retail | 2023 |
| Saturn Nexus Ltd | Information & communication | 2026 |
| Saturn Security Services Ltd | Administrative & support | 2024 |
| Satya Overseas Consultants Limited | Wholesale & retail | 2010 |
| Savile ROW Financial Services Ltd | Financial services | 2019 |
| Savior Solution Ltd | Information & communication | 2024 |
| Savior Security Ltd | Information & communication | 2019 |
| Savour Bakery Ltd | Manufacturing | 2025 |
| Savour Foods London Ltd | Hospitality | 2024 |
| Savour Foods Ltd | Hospitality | 2026 |
| Sawn Properties Ltd | Real estate | 2021 |
| Saza Properties Ltd | Real estate | 2025 |
| SB Construction Services Ltd | Construction | 2025 |
| SB Hotel Management Limited | Hospitality | 2026 |
| SB Prime Properties Ltd | Real estate | 2025 |
| SB. ALL Solution UK Ltd | Other services | 2019 |
| Sbfs Holdings Ltd | Administrative & support | 2024 |
| SBK Group Ltd | Construction | 2023 |
| SBR Business Corporation Ltd | Construction | 2018 |
| SBR Property Management Ltd | Households | 2022 |
| SC Cheema Limited | Transport & logistics | 2026 |
| SC Connect Ltd | Manufacturing | 2015 |
| Scalex Technology Ltd | Wholesale & retail | 2025 |
| Scallet Solutions Limited | Professional & scientific | 2014 |
| Scallop Mobile Chef Co Limited | Hospitality | 2021 |
| Sceptre Products Ltd | Wholesale & retail | 2019 |
| Schwartzbuild Limited | Construction | 2015 |
| Scla Limited | Manufacturing | 1972 |
| Scosh Limited | Wholesale & retail | 2023 |
| Screenscity Ltd | Manufacturing | 2022 |
| Scribe Property Services Ltd | Other services | 2019 |
| SD Cheema Limited | Transport & logistics | 2026 |
| SD Parking Limited | Administrative & support | 2025 |
| Sdgp Builds Ltd | Construction | 2026 |
| SDR Counselling Service Ltd | Health & social care | 2018 |
| Sea Contracts Ltd | Construction | 2016 |
| Sea Fish Mongers Limited | Wholesale & retail | 2025 |
| Seac Trading Ltd | Wholesale & retail | 2025 |
| Seal the Deal Online Ltd | Wholesale & retail | 2024 |
| Seantech Solutions Limited | Wholesale & retail | 2015 |
| Sectagon Limited | Other services | 2016 |
| Secure Drive Ltd | Administrative & support | 2025 |
| Secure Grace Limited | Construction | 2025 |