| Secure Security Guards Ltd | Administrative & support | 2017 |
| Secure Security Guards Services Ltd | Administrative & support | 2023 |
| Secure Shopfronts Ltd | Manufacturing | 2013 |
| Securex Software UK Ltd | Information & communication | 2015 |
| Security Services & Systems Limited | Information & communication | 2012 |
| Security Services Ltd | Administrative & support | 2024 |
| Security YOU Facility Services Limited | Administrative & support | 2024 |
| Sedav Health Limited | Wholesale & retail | 2026 |
| Sedo Ltd | Wholesale & retail | 2025 |
| Seed of Zeal Limited | Health & social care | 2026 |
| Seerha Constructions Limited | Construction | 2024 |
| Segtojj Care Services Limited | Health & social care | 2024 |
| Sehar Mustafa Ltd | Wholesale & retail | 2025 |
| Sejaza Limited | Information & communication | 2024 |
| Sekkat IT Services Ltd | Information & communication | 2020 |
| SEL Care Services Limited | Other services | 2019 |
| Seldek Ltd | Hospitality | 2016 |
| Selection House Ltd | Wholesale & retail | 2024 |
| Selectups Ltd | Wholesale & retail | 2025 |
| Seleno Everywear Ltd | Wholesale & retail | 2020 |
| Sell Buddy Ltd | Wholesale & retail | 2025 |
| Senarp Limited | Education | 2021 |
| Sense Eight Solutions Ltd | Wholesale & retail | 2026 |
| Senspired Ltd | Education | 2022 |
| Septimiu Trans Travel Ltd | Transport & logistics | 2025 |
| Sercy Ltd | Wholesale & retail | 2016 |
| Serdar Properties Limited | Real estate | 2021 |
| Serene Nights Ltd | Hospitality | 2024 |
| Serengenix Limited | Wholesale & retail | 2026 |
| Serenity Care and Support Services Limited | Administrative & support | 2025 |
| Serna Services Ltd | Construction | 2023 |
| Serve London Ltd | Professional & scientific | 2022 |
| Server Technologies Limited | Wholesale & retail | 2018 |
| Service Supreme Management Ltd | Professional & scientific | 2012 |
| Services Group Limited | Construction | 2022 |
| Servicure Ltd | Administrative & support | 2020 |
| Servizo Ltd | Administrative & support | 2024 |
| Sethi & Co Limited | Professional & scientific | 2010 |
| Setoofficial Ltd | Manufacturing | 2024 |
| Sevenstars Electronics Ltd | Wholesale & retail | 2022 |
| Sevenxcap Ltd | Financial services | 2025 |
| SFA Holdings Limited | Real estate | 2019 |
| SFB Traders Limited | Wholesale & retail | 2021 |
| SG Fit Ltd | Arts & recreation | 2023 |
| SGS Building Solutions Ltd | Construction | 2018 |
| SGS Properties and Lettings Ltd | Real estate | 2024 |
| SH & WS Company Limited | Other services | 2020 |
| SH Habib Company Ltd | Wholesale & retail | 2025 |
| SH Motor Group Ltd | Wholesale & retail | 2026 |
| Shaal Tech Limited | Construction | 2011 |
| Shaaronjay Ventures Ltd | Wholesale & retail | 2025 |
| Shaban Properties Limited | Real estate | 1998 |
| Shabaz L Ltd | Health & social care | 2022 |
| Shadhily Society UK | Other services | 2016 |
| Shaf Electrical Limited | Construction | 2017 |
| Shafkatakbar and Company Ltd | Professional & scientific | 2023 |
| Shahdynamics Ltd | Wholesale & retail | 2024 |
| Shahzad Property Ltd | Real estate | 2022 |
| Shahzibarbers Ltd | Other services | 2025 |
| Shajj Construction Ltd | Construction | 2025 |
| Shajj Utility Limited | Energy | 2016 |
| Shalli's London Limited | Wholesale & retail | 2023 |
| Shangmic Limited | Wholesale & retail | 2022 |
| Shanice Harris Ltd | Extraterritorial | 2023 |
| Shaoom Limited | Information & communication | 2024 |
| Shapla Event Management Ltd | Transport & logistics | 2020 |
| Sharc Holdings Limited | Real estate | 2023 |
| Sharia Complaint Health Advisors Ltd | Health & social care | 2025 |
| Sharif Fashions UK Limited | Manufacturing | 2006 |
| Sharif Properties (UK) Ltd | Real estate | 2014 |
| Shariff Properties Limited | Real estate | 2025 |
| Sharon Idehen Ltd | Health & social care | 2023 |
| Sharp Blend Limited | Construction | 2020 |
| Sharp Security Solutions Ltd | Wholesale & retail | 2019 |
| Sharps Barbers Ltd | Other services | 2024 |
| Shawarma Shack Limited | Hospitality | 2020 |
| Shay Associates Limited | Education | 2013 |
| Shayaan Ltd. | Administrative & support | 2002 |
| Shaz & Shami Limited | Hospitality | 2025 |
| Shaz& Co Trading Ltd | Wholesale & retail | 2025 |
| Shazco Ltd | Construction | 2025 |
| Shearforce Security Services (UK) Limited | Administrative & support | 1999 |
| Shegora Enterprise Limited | Wholesale & retail | 2025 |
| Sheikh and Brothers Limited | Wholesale & retail | 2025 |
| Shekinah Miracle Centre Limited | Education | 2025 |
| Shelton Services Ltd | Other services | 2024 |
| Shepherdd Global Consulting Ltd | Professional & scientific | 2022 |
| Shibli Consultancy Ltd | Professional & scientific | 2015 |
| Shield Consultancy Ltd | Information & communication | 2023 |
| Shield Master Security Ltd | Administrative & support | 2024 |
| Shift & Shine Limited | Manufacturing | 2017 |
| Shifters Moving Company Ltd | Transport & logistics | 2024 |
| Shiftkey Properties Ltd | Real estate | 2024 |
| Shiftmint Ltd | Administrative & support | 2025 |
| Shildon Care Limited | Health & social care | 2025 |
| Shilhot Bazar Ltd | Wholesale & retail | 2024 |
| Shin Lubricants Ltd | Wholesale & retail | 2024 |
| Shine Construction London Ltd | Construction | 2026 |
| Shining Horizon Limited | Wholesale & retail | 2026 |
| Shining Star PVT Ltd | Wholesale & retail | 2026 |