| Shaw (Lancs) Tool Co 2007 Ltd | Manufacturing | 2007 |
| SHB Ventures Ltd | Wholesale & retail | 2023 |
| Shedd Express Ltd | Transport & logistics | 2026 |
| Shelley Fletcher Limited | Other services | 2012 |
| Sherifdeen Ventures Limited | Health & social care | 2022 |
| Shine Through Autism CIC | Health & social care | 2026 |
| Shine Trades Limited | Wholesale & retail | 2024 |
| SHK Scientific Solutions Limited | Professional & scientific | 2015 |
| Shop Lettings Ltd | Real estate | 2019 |
| Shop Reform Studios Ltd | Wholesale & retail | 2022 |
| Shoplyra Ltd | Wholesale & retail | 2026 |
| Shore Digital Ltd | Wholesale & retail | 2024 |
| Shorty Enterprises Ltd | Wholesale & retail | 2024 |
| Shredtec Recyclers Limited | Water & waste | 2006 |
| SI Consulting Services Ltd | Information & communication | 2023 |
| SI Foods (Ashton) Ltd | Hospitality | 2015 |
| Siana Project Management Ltd | Professional & scientific | 2015 |
| Siawa Limited | Wholesale & retail | 2026 |
| Sibbs Properties Ltd | Real estate | 2019 |
| Silk Travel London Ltd | Administrative & support | 2022 |
| Silky Boxers Ltd | Manufacturing | 2026 |
| Silver Mount Trade Ltd | Wholesale & retail | 2024 |
| Silver Service Cruises Limited | Administrative & support | 2011 |
| Silverbridge Supply Ltd | Wholesale & retail | 2026 |
| Simm Surveillance Limited | Other services | 2019 |
| Simms International Realty Limited | Real estate | 2016 |
| Simple Physio and Rehab Ltd | Health & social care | 2017 |
| Simplfy Marketing Ltd | Professional & scientific | 2025 |
| Simplified Software Solutions Limited | Information & communication | 2021 |
| Sincerely Yours 1 Ltd | Other services | 2025 |
| SITE03 Ltd | Professional & scientific | 2014 |
| Siya Photography Studio Limited | Professional & scientific | 2025 |
| SK Building & Renovations Ltd | Construction | 2021 |
| SK Clad Solutions Northwest Ltd | Construction | 2026 |
| Skidmore Electrical Limited | Energy | 2006 |
| Skin Envy Aesthetics Limited | Other services | 2017 |
| Skinbykp Ltd | Other services | 2022 |
| Skincare Beauty Clinic Ltd | Other services | 2023 |
| Skips and Recycling Limited | Water & waste | 2021 |
| Skools OUT Ltd. | Administrative & support | 1999 |
| Sky Maintenance & Repair Services Ltd | Other services | 2025 |
| Sky Maintenance Ltd | Administrative & support | 2024 |
| Sky Repair Services MCR Ltd | Other services | 2024 |
| Skydiving Smejo Ltd. | Arts & recreation | 2016 |
| Skydivingteam Markiz Bialecki Ltd. | Arts & recreation | 2015 |
| Skylinks Travel and Tours Ltd | Transport & logistics | 2023 |
| Skyluxe Motors Ltd | Wholesale & retail | 2022 |
| Skyniq Limited | Wholesale & retail | 2025 |
| Slbus Limited | Real estate | 2018 |
| Slcb Pardoe Limited | Hospitality | 2025 |
| Slipper Inc. Limited | Wholesale & retail | 2020 |
| SLS Northwest Properties Ltd | Real estate | 2025 |
| SM Bown Enterprises Limited | Construction | 2006 |
| SM Care & Support Ltd | Public administration | 2023 |
| SM Project Consultancy Ltd | Information & communication | 2024 |
| Small Dog Warehouse Ltd | Wholesale & retail | 2020 |
| Smart Builders Mossley UK Ltd | Construction | 2016 |
| Smart Circle Limited | Administrative & support | 2025 |
| Smart Linen Solutions Ltd | Administrative & support | 2024 |
| Smart Multiplex Solutions Ltd | Information & communication | 2017 |
| Smart Rooflines Limited | Extraterritorial | 2023 |
| Smart Stop Northwest Ltd | Administrative & support | 2025 |
| Smart Stop Shop Ltd | Wholesale & retail | 2025 |
| Smart Study Support Limited | Education | 2025 |
| Smart Trading Group Limited | Financial services | 2019 |
| Smart Trending Ltd | Wholesale & retail | 2023 |
| Smart-Tec Roofing Ltd | Construction | 2010 |
| Smart-Tec Waterproofing Ltd | Construction | 2019 |
| Smartway Construction Ltd | Construction | 2026 |
| Smartway Energy Ltd | Construction | 2024 |
| Smartway Health and Social Care Limited | Health & social care | 2015 |
| Smartway(North West) Care Limited | Health & social care | 2025 |
| Smiletique Events Limited | Hospitality | 2024 |
| Smith & SON Roof Slates Ltd | Wholesale & retail | 2026 |
| Smith Plastics Ltd | Manufacturing | 2022 |
| Smoke City Ltd | Wholesale & retail | 2026 |
| Snacked Ltd | Hospitality | 2025 |
| Snikify Ltd | Wholesale & retail | 2026 |
| SNOOKS247 Ltd | Arts & recreation | 2024 |
| SNOOKZ247 Ltd | Arts & recreation | 2026 |
| Snugg Properties Limited | Construction | 2017 |
| Social Distribution Ltd | Wholesale & retail | 2019 |
| Socks Joy Ltd | Wholesale & retail | 2023 |
| Softbloom Ltd | Wholesale & retail | 2025 |
| Softkozzy Ltd | Wholesale & retail | 2026 |
| Sohal Traders Limited | Wholesale & retail | 2017 |
| SOL Tameside Limited | Hospitality | 2024 |
| Solgreen Consultants Ltd | Wholesale & retail | 2018 |
| Solidarity Properties LLP | | 2007 |
| Solotec Scientific Limited | Manufacturing | 2015 |
| Solution Print Limited | Manufacturing | 2011 |
| Solutionsignature Ltd | Professional & scientific | 2023 |
| Soma Movement Ltd | Arts & recreation | 2025 |
| Sons of Satoshi Ltd | Wholesale & retail | 2020 |
| Soot Destroyer Limited | Administrative & support | 2019 |
| Soso's Treats Ltd | Hospitality | 2024 |
| Soss Clothing Limited | Wholesale & retail | 2023 |
| Sovereign Pro Wrestling Limited | Arts & recreation | 2022 |
| Space Joinery and Building Limited | Construction | 2019 |
| Spar Investments Limited | Real estate | 2019 |