| SA Food Supermarket Limited | Wholesale & retail | 2024 |
| SA Homes Limited | Real estate | 2019 |
| SA1 Waterfront Development Ltd | Construction | 2017 |
| Saba Enterprises Ltd | Wholesale & retail | 2026 |
| Sabahussain Limited | Wholesale & retail | 2024 |
| Saca Padel Ltd | Wholesale & retail | 2025 |
| Saddleworth Dodgers Ltd | Arts & recreation | 2024 |
| Saddleworth Pizza Ltd | Hospitality | 2024 |
| Saddleworth Portfolio Services Ltd | Professional & scientific | 2022 |
| Safe & Sound Properties Limited | Real estate | 2016 |
| Safe Asbestos Removal Ltd | Water & waste | 2020 |
| Safety Guide Ltd | Wholesale & retail | 2016 |
| Saffer Cooper Ltd. | Administrative & support | 2003 |
| Saffron 13 Propco Limited | Real estate | 2022 |
| Saffron Mortgages Limited | Financial services | 2026 |
| SAH HR Services Limited | Professional & scientific | 2016 |
| Sahara Fried & Grill Chicken Ashton Ltd | Hospitality | 2018 |
| Sahara Marketing Ashton Ltd | Professional & scientific | 2024 |
| Saharaproject Ltd | Wholesale & retail | 2025 |
| Saira Driving School Ltd | Education | 2025 |
| Sairak Ltd | Health & social care | 2025 |
| Saishree Medical Services 2018 Limited | Health & social care | 2025 |
| Saito Art Ltd | Manufacturing | 2020 |
| Sajji Limited | Information & communication | 2025 |
| Sala Futsal Club CIC | Education | 2024 |
| Salaar Private Limited | Other services | 2023 |
| Salem Developments Limited | Real estate | 2023 |
| Saler Ltd | Real estate | 2013 |
| Sales Hub Solutions Ltd | Wholesale & retail | 2025 |
| Sales Instincts Limited | Professional & scientific | 2003 |
| Salomon Enterprise Limited | Wholesale & retail | 2024 |
| Salsa Beauty Rooms Limited | Other services | 2006 |
| Salters Group Ltd | Wholesale & retail | 2019 |
| Saltish Chicken and Dessert Ltd | Hospitality | 2024 |
| Saltish Ltd | Other services | 2015 |
| SAM Mechanic Autos Ltd | Wholesale & retail | 2025 |
| SAM Perry Welding Limited | Construction | 2026 |
| Samad Commercial Ltd | Real estate | 2025 |
| Samgba Limited | Health & social care | 2025 |
| Samson Boxing Gym Ltd. | Arts & recreation | 2020 |
| Sanam Jalebi Ltd | Hospitality | 2025 |
| Sanan Servicse Ltd | Administrative & support | 2024 |
| Sandhole Farm Ltd | Agriculture & fishing | 2018 |
| Sandhole Stables Ltd | Agriculture & fishing | 2018 |
| Sandra Nield Agencies Ltd | Professional & scientific | 2015 |
| Sandsliders Ltd | Manufacturing | 2017 |
| Saniserve Limited | Administrative & support | 2025 |
| Sant Restaurant's Ltd | Hospitality | 2023 |
| Sapharm Ltd | Wholesale & retail | 2021 |
| SAR Group NW Limited | Financial services | 2024 |
| Sarah Evans Employment Law Ltd | Professional & scientific | 2020 |
| Sarah Mini Market NW Ltd | Wholesale & retail | 2025 |
| Sarratrade Limited | Wholesale & retail | 2026 |
| Sarwar Forecourts Ltd | Wholesale & retail | 2026 |
| Sassy Salons Limited | Other services | 2015 |
| Sauce Games Ltd | Information & communication | 2026 |
| Sawtooth Software UK Limited | Administrative & support | 2021 |
| SB & Sons Transport Services Limited | Transport & logistics | 2022 |
| SB Tandoori Ltd | Hospitality | 2023 |
| Sb&Aj Traders Limited | Wholesale & retail | 2025 |
| SBG Community Club CIC | Education | 2024 |
| SBG Taverns Limited | Hospitality | 2020 |
| SBT Engineering Group Limited | Financial services | 2015 |
| SBT Holdings Limited | Financial services | 2007 |
| SBT Northwest Division Limited | Financial services | 2025 |
| Scaffway Ltd | Construction | 2019 |
| Schaudhery Ltd | Wholesale & retail | 2022 |
| Schofield Home Investments Ltd | Real estate | 2024 |
| Schofield Lowe Properties Ltd | Real estate | 2024 |
| Sciens Limited | Administrative & support | 2022 |
| Scitech Ltd | Education | 2019 |
| Scott and Sons Flooring Specialist Ltd | Construction | 2024 |
| Scott Gledhill Limited | Arts & recreation | 2008 |
| Scrub-A-Dub Fresh Ltd | Administrative & support | 2024 |
| SD Proclean Ltd | Administrative & support | 2025 |
| Seamless Healthcare Limited | Health & social care | 2008 |
| Seaspray High Pressure Systems Limited | Extraterritorial | 2015 |
| Secluded Events Worldwide Ltd | Arts & recreation | 2020 |
| Securesoft Consultants Ltd. | Information & communication | 2014 |
| Seenays Car Sales Ltd | Wholesale & retail | 2024 |
| Segmentation Group Limited | Information & communication | 2015 |
| Sell-Source Ltd | Information & communication | 2005 |
| Selyn Ltd | Construction | 2022 |
| Semseo Ltd | Information & communication | 2002 |
| Send Inspirations Ltd | Education | 2020 |
| Sensory Stars Ltd | Health & social care | 2021 |
| Sentient Networks Limited | Information & communication | 2023 |
| Seven Star Kashmiri Takeaway Ltd | Hospitality | 2023 |
| SH Dessert Bar Ltd | Other services | 2023 |
| SH Marne Consultancy Ltd | Professional & scientific | 2025 |
| Shadow Plumbing and Heating Ltd | Construction | 2023 |
| Shah Taxi Rental Limited | Transport & logistics | 2024 |
| Shahbaz Properties Ltd | Real estate | 2025 |
| Shaheen Textile Ltd | Wholesale & retail | 2025 |
| Shahmeer Store Ltd | Wholesale & retail | 2026 |
| Shahveer's Ltd | Wholesale & retail | 2026 |
| SHAHZAIB007 Ltd | Wholesale & retail | 2025 |
| Shamraiz (UK) Limited | Wholesale & retail | 2017 |
| Shanay Limited | Wholesale & retail | 2025 |
| Shasho UK Limited | Wholesale & retail | 2020 |