| Sparkle Dental Care Limited | Health & social care | 2012 |
| Specialist Automotive Solutions Limited | Wholesale & retail | 2017 |
| Speri Design Ltd | Wholesale & retail | 2024 |
| Spitshine Ltd | Other services | 2024 |
| SPL Fire Safety Ltd | Professional & scientific | 2012 |
| Splinter Scenery Ltd. | Manufacturing | 2009 |
| Sportcity Body Repairs Ltd | Wholesale & retail | 2019 |
| Spot Sale Trading Ltd | Wholesale & retail | 2026 |
| Spray a Door Ltd | Professional & scientific | 2024 |
| Springwood Way (A-U-L) Management Company Ltd | Households | 2002 |
| Squarefold Limited | Real estate | 1981 |
| Squink Digital Ltd | Professional & scientific | 2024 |
| SR Plates Ltd | Wholesale & retail | 2020 |
| SSR Traders UK Ltd | Wholesale & retail | 2025 |
| ST Albans Autocare Limited | Wholesale & retail | 2017 |
| ST Peter's Community Partnership | Administrative & support | 2003 |
| ST. Peter's Trading Partnership (Greenscape) Ltd. | Administrative & support | 2007 |
| Stable Your Mind Ltd | Health & social care | 2024 |
| Stacey Electrical Services Limited | Construction | 2020 |
| Stacked Burgers & Desserts Limited | Hospitality | 2021 |
| Stalybridge Construction Limited | Construction | 2024 |
| Stalybridge Valeting Ltd | Wholesale & retail | 2018 |
| Stamford Cars UK Limited | Transport & logistics | 2005 |
| Stamford Investments N/W Ltd | Financial services | 2024 |
| Stamford Park Trust | Education | 2018 |
| Stamford Preservations Limited | Construction | 2014 |
| Stand Strong Collective CIC | Education | 2025 |
| Stanway Pipework and GAS Limited | Construction | 2016 |
| Star Cutouts Limited | Manufacturing | 2005 |
| Star Diamond Limited | Wholesale & retail | 2024 |
| Starhart Partners Limited | Professional & scientific | 2025 |
| Starr Plumbing and Heating Limited | Construction | 2021 |
| Start&Go Cars Ltd | Wholesale & retail | 2025 |
| Static Master Ltd | Administrative & support | 2009 |
| Statimeter (Wrexham) Limited | Manufacturing | 2025 |
| Steadfast Compliance Ltd | Professional & scientific | 2026 |
| Steam Direct National Limited | Manufacturing | 2014 |
| Stelfox Design Limited | Professional & scientific | 2013 |
| Stellify Domestic Services Ltd | Construction | 2022 |
| Stellify Electrical Services Ltd | Construction | 2018 |
| Stellify Property Ltd | Real estate | 2024 |
| Step Ahead Resource Services Ltd | Health & social care | 2010 |
| Step Forward to Independence Limited | Health & social care | 2025 |
| Steral Products Limited | Manufacturing | 2021 |
| Steriadvance Ltd | Wholesale & retail | 2023 |
| Sterling Finance IFA Limited | Financial services | 2015 |
| Stern Engineering Limited | Other services | 2017 |
| Steven Cheetham Ltd | Information & communication | 2019 |
| Stevensons Accident Repair Centre Limited | Wholesale & retail | 2016 |
| Still Human 2045 Ltd | Information & communication | 2020 |
| Stockport and District Mind | Health & social care | 2006 |
| Stockport Road Convenience Store Ltd | Wholesale & retail | 2025 |
| Stockport Symphony Orchestra Productions Ltd | Arts & recreation | 2017 |
| Stokvis Plates (PHE) Limited | Manufacturing | 2024 |
| Stone With Steel Ltd | Manufacturing | 2024 |
| Stoneages Healthcare Ltd | Administrative & support | 2024 |
| Stonecrest Build & Trade Ltd | Construction | 2025 |
| Stonevia Ltd | Construction | 2026 |
| Stopstress Limited | Health & social care | 2014 |
| Storecraft Ltd | Construction | 2026 |
| Stratford-Dene Ltd | Real estate | 2003 |
| Stratton Oakmont Inc Limited | Real estate | 2026 |
| Strom Products and Information Limited | Wholesale & retail | 2025 |
| Student Redress Ltd | Professional & scientific | 2026 |
| STUDENTS4HOUSES Ltd | Real estate | 1999 |
| Studiomacs Limited | Wholesale & retail | 2009 |
| Study Orbit Global Ltd | Education | 2025 |
| Style Builders Limited | Construction | 2012 |
| Subsidia Technica Ltd | Education | 2020 |
| Sufian Gebal Ltd | Wholesale & retail | 2025 |
| Sulevi Construction Ltd | Construction | 2022 |
| Sunny Manchester Limited | Other services | 2021 |
| Sunnymesh Limited | Construction | 2022 |
| Sunshine Care and Community Support Services CIC | Professional & scientific | 2025 |
| Sunshine Nursery Chadderton Limited | Education | 2004 |
| Supanovatv Ltd | Information & communication | 2026 |
| Super Car Spa Drive Thru Ltd | Other services | 2019 |
| Superior Beds Limited | Manufacturing | 2021 |
| Superior Linen Limited | Wholesale & retail | 2021 |
| Supertrek Ltd | Wholesale & retail | 2021 |
| Supertrolley Ltd | Wholesale & retail | 2019 |
| Supply and Recruit Limited | Administrative & support | 2021 |
| Sure Finance NW Ltd | Financial services | 2023 |
| Surely NOT Productions Ltd | Arts & recreation | 2026 |
| Surface JET Solutions Ltd | Administrative & support | 2025 |
| Surveying & Re-Inspections Ltd | Professional & scientific | 2022 |
| Surveyor Support (Apc/Cpd Training) Limited | Education | 2023 |
| Sustainable Trade Frames Limited | Manufacturing | 2025 |
| Sutherland House Management Company (1995) Limited | Hospitality | 1995 |
| SVB Manchester Limited | Administrative & support | 2018 |
| Sveston UK Ltd | Wholesale & retail | 2026 |
| SVS Group Ltd | Wholesale & retail | 2024 |
| SW9 Property Holdings Ltd | Real estate | 2018 |
| Sweetbitshake Ltd | Hospitality | 2022 |
| Swiffttt Limited | Information & communication | 2025 |
| Swift Cargo International Limited | Other services | 2009 |
| Swift Serve FM Ltd | Administrative & support | 2025 |
| Swift Trend Ltd | Wholesale & retail | 2025 |
| Swim Aura Ltd | Wholesale & retail | 2025 |
| Swirlz Ashton Ltd | Manufacturing | 2026 |