| Safe Scene Cleaning Limited | Administrative & support | 2024 |
| Safer Together Safeguarding Ltd | Education | 2026 |
| Safetynet IT Ltd | Information & communication | 2007 |
| Saffron Altrincham Ltd | Hospitality | 2025 |
| Saffronfoods & Consultants Limited | Hospitality | 2014 |
| Sage Green Associates Limited | Administrative & support | 2021 |
| Sage Thinking Limited | Professional & scientific | 2025 |
| Sahana Properties Limited | Real estate | 2024 |
| Sahil Food Consultancy Limited | Hospitality | 2022 |
| Sahjanand Properties Ltd | Real estate | 2025 |
| Sahmaetejproducts Limited | Wholesale & retail | 2026 |
| Sahyadri CIC | Arts & recreation | 2025 |
| SAI ASM Ltd | Wholesale & retail | 2020 |
| SAI Guru Priya Limited | Information & communication | 2010 |
| SAI Reddy Ltd | Health & social care | 2021 |
| SAI SKN Limited | Wholesale & retail | 2023 |
| SAI Sree Consulting Limited | Information & communication | 2012 |
| Saif Ortho Limited | Health & social care | 2023 |
| Saifazz Limited | Real estate | 2024 |
| Saii Consulting Limited | Administrative & support | 2015 |
| Sail Holdings Limited | Health & social care | 2024 |
| Sailing Vessel Impromptu Ltd | Transport & logistics | 2013 |
| Saint Mortgage Services Limited | Financial services | 2021 |
| Saira's International Foods Ltd | Wholesale & retail | 2025 |
| Sairama Limited | Real estate | 2022 |
| Sajjad Medics Limited | Health & social care | 2019 |
| Saks Associates Limited | Professional & scientific | 2026 |
| SAL Healthcare Limited | Health & social care | 2014 |
| Salams Health and Wellbeing Ltd | Health & social care | 2022 |
| Salariz Limited | Health & social care | 2009 |
| Saldac Law Group Limited | Professional & scientific | 2025 |
| Sale Hydro Ltd | Wholesale & retail | 2010 |
| Sale Moor Eyecare Limited | Wholesale & retail | 2016 |
| Salem Digital Limited | Professional & scientific | 2024 |
| Saliency Ltd | Professional & scientific | 2013 |
| Salient Properties Ltd | Real estate | 2020 |
| Salisbury Construction Management Ltd | Construction | 2023 |
| Salisbury Court (Jesmond Road) Management Company Limited | Households | 1990 |
| Salisbury Property Group Ltd | Real estate | 2018 |
| Sally Green Books Limited | Information & communication | 2016 |
| Salthouse Sales Limited | Wholesale & retail | 2008 |
| Salubrious Healthcare Ltd | Health & social care | 2020 |
| Salz Properties Limited | Real estate | 2017 |
| Salzano Holdings Limited | Financial services | 2026 |
| SAM & USM Co Ltd | Extraterritorial | 2022 |
| SAM Horsefield Ltd | Professional & scientific | 2014 |
| SAM Joseph Limited | Manufacturing | 2015 |
| SAM Learning Holdings Limited | Professional & scientific | 2007 |
| SAM Learning Ltd. | Information & communication | 1993 |
| SAM Properties Inc Ltd | Administrative & support | 2008 |
| Samba & Saffron Ltd | Hospitality | 2025 |
| Samikhas Property Ltd | Real estate | 2023 |
| Samnmax Limited | Professional & scientific | 2017 |
| Samphire Holdco Limited | Financial services | 2025 |
| Samphire Services Limited | Financial services | 2021 |
| Samriddh Limited | Real estate | 2026 |
| Samrine Limited | Other services | 2019 |
| Samz Barbers Ltd | Other services | 2019 |
| Sana's Medics Ltd | Health & social care | 2019 |
| Sanaya Medics Limited | Health & social care | 2014 |
| Sana’A Cafe Ltd | Hospitality | 2025 |
| Sanctum 1782 Limited | Hospitality | 2025 |
| Sand Investments (UK) Limited | Real estate | 2018 |
| Sanda Stensel Trading Limited | Administrative & support | 2016 |
| Sandacre Technology Limited | Information & communication | 2003 |
| Sandbach Limited | Arts & recreation | 2012 |
| Sandbach Physiotherapy & Sports Injury Clinic Limited | Health & social care | 2003 |
| Sanders Developments Limited | Real estate | 2001 |
| Sandhills East Ltd. | Information & communication | 2011 |
| Sandpiper (Congleton) RTM Company Limited | Households | 2007 |
| Sandringham Court Management Company (Wilmslow) Limited | Households | 1982 |
| Sandringham House Limited | Real estate | 2021 |
| Sands Capital Advisors - UK Ltd. | Professional & scientific | 2021 |
| Sandstone Real Estate Investments Limited | Real estate | 2025 |
| Sanjeet Kamath Private Limited | Health & social care | 2017 |
| Sanka's Afro Caribbean Ltd | Hospitality | 2026 |
| Sanrouf London Ltd | Professional & scientific | 2017 |
| Santek Consulting Limited | Administrative & support | 2019 |
| Santic Limited | Administrative & support | 2012 |
| Santo Domingo Limited | Professional & scientific | 2014 |
| Sanvi Software Limited | Professional & scientific | 2019 |
| Sanzah Limited | Information & communication | 2025 |
| Saoirse Aine Ltd | Real estate | 2025 |
| SAP GRC IT Limited | Administrative & support | 2014 |
| SAPBASIS8 Ltd | Administrative & support | 2009 |
| Saphi Associates Limited | Professional & scientific | 2013 |
| Saphyre U.K. Limited | Information & communication | 2024 |
| Sapien Coaching & Development Ltd | Professional & scientific | 2019 |
| Sapientia Sofia Limited | Wholesale & retail | 2025 |
| Saplings Management Company Ltd | Households | 2023 |
| Sara Associates Limited | Health & social care | 2010 |
| Sara Consulting Limited | Information & communication | 2024 |
| Sara Medics Limited | Other services | 2014 |
| Sarah Eaton Garden Designs Limited | Professional & scientific | 2015 |
| Sarah Eglin Nutrition Limited | Health & social care | 2022 |
| Sarah Robinson Ltd | Other services | 2024 |
| Sareb Limited | Professional & scientific | 2012 |
| Sarpca Limited | Administrative & support | 2016 |
| Sarsq Consultancy Limited | Professional & scientific | 2026 |
| Sarwari MCR Ltd | Hospitality | 2022 |