| SAS Advisory Ltd | Information & communication | 2022 |
| SAS Rose Associates Ltd | Professional & scientific | 2005 |
| SAS Tech Solutions Limited | Professional & scientific | 2024 |
| Sasesh Ltd | Construction | 2025 |
| Sassy P Ltd | Other services | 2022 |
| Satavia Ltd | Information & communication | 2013 |
| Satcbshop Ltd. | Wholesale & retail | 2015 |
| Satnam Estates Limited | Real estate | 2017 |
| Saturn Group Limited | Professional & scientific | 2022 |
| Saturn UK Group Ltd | Administrative & support | 2017 |
| Satvik Food Consultancy Limited | Hospitality | 2021 |
| Satyr Legal Limited | Professional & scientific | 2024 |
| Savannah Wisdom | Health & social care | 2011 |
| Save and Insure Limited | Financial services | 2014 |
| Savvy Thinker Limited | Professional & scientific | 2024 |
| Sawwad Ltd | Health & social care | 2024 |
| Saxon Finance Solutions Limited | Professional & scientific | 2011 |
| Saxon Park Corby Ltd | Financial services | 2025 |
| Saxton Engineering Ltd | Manufacturing | 2009 |
| SB Contract Services Limited | Professional & scientific | 2025 |
| SB Cyber Limited | Information & communication | 2024 |
| SB Site Management Limited | Professional & scientific | 2023 |
| Sbdrm Limited | Professional & scientific | 2015 |
| SBE Engineering Consultancy Limited | Professional & scientific | 2023 |
| SBF Consulting Ltd | Administrative & support | 2026 |
| SBK & Associates Ltd | Information & communication | 2017 |
| Sbpl Limited | Hospitality | 2025 |
| SBR One Nominee Limited | Real estate | 2026 |
| SBR Two Nominee Limited | Real estate | 2026 |
| SC Aspira Ltd | Health & social care | 2024 |
| SC Dental Ltd | Health & social care | 2022 |
| SC Europe Limited | Financial services | 2020 |
| SC Global Partners Limited | Professional & scientific | 2023 |
| SC Private Care Limited | Health & social care | 2023 |
| Scan Consulting Limited | Public administration | 2018 |
| Scan HR Ltd | Administrative & support | 2025 |
| Scarlett James Holdings Ltd | Financial services | 2025 |
| Scarlett James Properties Ltd | Real estate | 2021 |
| Scarus Engineering Consultancy Ltd | Professional & scientific | 2024 |
| SCC Cars Limited | Wholesale & retail | 2017 |
| Scene IT ALL Limited | Professional & scientific | 2019 |
| SCH FM Solutions Limited | Professional & scientific | 2024 |
| Schiehallion Holdings Limited | Financial services | 2026 |
| Scho Holdings Limited | Financial services | 2025 |
| Schofield Optometric Services Limited | Health & social care | 2009 |
| Schofield Watson Investments Limited | Real estate | 2024 |
| Scholar's Green Cheadle Hulme Limited | Real estate | 2021 |
| Scholars Clinical Ltd | Professional & scientific | 2024 |
| Scholars Walk (Gorton) Management Company Limited | Households | 2004 |
| School for Gifted and Talented CIC | Education | 2018 |
| School Road Property Management Company Limited | Households | 2009 |
| School-E Ltd | Education | 2011 |
| Science Adventure Consulting Limited | Professional & scientific | 2023 |
| Scimatics Solutions Limited | Information & communication | 2024 |
| SCL IT Limited | Information & communication | 2022 |
| Scone Garden Limited | Professional & scientific | 2023 |
| Scope Properties Limited | Real estate | 2018 |
| Scopely UK Limited | Information & communication | 2019 |
| Scorpic Limited | Real estate | 2022 |
| Scorpius Limited | Professional & scientific | 2023 |
| Scotsoft Limited | Information & communication | 2019 |
| Scott Beaumont Limited | Professional & scientific | 2023 |
| Scott Jackson Services Limited | Professional & scientific | 2017 |
| Screenscraper Limited | Information & communication | 2025 |
| Scribble PR Limited | Professional & scientific | 2024 |
| Scribbleaway Ltd | Professional & scientific | 2005 |
| Scrum Easy Consulting Limited | Professional & scientific | 2022 |
| Scrunchii Limited | Wholesale & retail | 2025 |
| SCS Project Solutions Limited | Professional & scientific | 2020 |
| Sctc (FM) Limited | Professional & scientific | 2011 |
| Scullard & Co Limited | Professional & scientific | 2009 |
| Scullard (Alderley Edge) Limited | Professional & scientific | 2023 |
| Scullard Marketing Solutions Limited | Professional & scientific | 2019 |
| Scullard Payroll Solutions Limited | Extraterritorial | 2019 |
| Sculpt Pro Aesthetics Limited | Wholesale & retail | 2017 |
| Sculpted Music Limited | Administrative & support | 2007 |
| Scuriatti Tortora Ltd | Financial services | 2026 |
| Scylla Services Limited | Professional & scientific | 2023 |
| SD Gardening Services Ltd | Administrative & support | 2016 |
| SD Heating & Plumbing Limited | Construction | 2017 |
| SDA Ventures Limited | Arts & recreation | 2025 |
| Sdbc Consulting Ltd | Information & communication | 2022 |
| Sdhdigital Limited | Wholesale & retail | 2010 |
| SDL Healthcare Limited | Extraterritorial | 2010 |
| SDM Limited | Professional & scientific | 2021 |
| Sdsl Ltd | Administrative & support | 2025 |
| Sea Support Services Ltd | Health & social care | 2009 |
| Seal Energy Consult Limited | Professional & scientific | 2023 |
| Seal Films Limited | Administrative & support | 2007 |
| Seamflow Ltd. | Information & communication | 2025 |
| Seamons Moss Community Association | Education | 2007 |
| Search and Compare Group Limited | Financial services | 2023 |
| Seaside Holiday Breaks Limited | Hospitality | 2017 |
| Seasonwear Ltd | Wholesale & retail | 2025 |
| Seb-Jet Ltd | Administrative & support | 2023 |
| Seban Consulting Limited | Administrative & support | 2022 |
| Sebden Holdings Limited | Financial services | 2021 |
| Sebden Steel Limited | Professional & scientific | 1995 |
| Sebden Steel PST Limited | Professional & scientific | 1999 |
| Sebden Steel Quest Limited | Administrative & support | 1998 |