| Ruddell Mccann Wells Limited | Real estate | 2025 |
| Rule and Protect Ltd | Information & communication | 2026 |
| Rule Number One Limited | Professional & scientific | 2017 |
| Rulecorp Limited | Professional & scientific | 2016 |
| Rules of Faith (IP) Limited | Extraterritorial | 2023 |
| Rullion Build Limited | Administrative & support | 1991 |
| Rullion Engineering Limited | Administrative & support | 1973 |
| Rullion IT Plus Limited | Administrative & support | 1987 |
| Rullion Limited | Professional & scientific | 1993 |
| Ruma Marketing Ltd | Professional & scientific | 2021 |
| Rumblings Ltd | Arts & recreation | 2014 |
| Runcorn Rowing Club Limited | Administrative & support | 2017 |
| Runner Paradise Ltd Limited | Education | 2022 |
| Rupert Himself Limited | Other services | 1974 |
| Ruscom Limited | Professional & scientific | 2017 |
| Ruskin Lodge Management Co. Limited | Households | 2007 |
| Rustic Alty Ltd | Hospitality | 2019 |
| Ruth Hale Consultancy Services Limited | Health & social care | 2023 |
| Ruthin Court RTM Company Limited | Households | 2025 |
| Ruvo Life Ltd | Financial services | 2025 |
| RVK Legal Services Limited | Professional & scientific | 2024 |
| Rvst Ltd | Wholesale & retail | 2025 |
| RWC Global Limited | Professional & scientific | 2012 |
| Rwcm Consulting Limited | Professional & scientific | 2025 |
| RWL Advanced Solutions UK Limited | Information & communication | 2020 |
| Rxrox Limited | Wholesale & retail | 2016 |
| Ryan Clarke Consulting Limited | Administrative & support | 2024 |
| Ryanwall Limited | Health & social care | 2016 |
| Ryder Finance Limited | Financial services | 1998 |
| RYM Holdings Limited | Professional & scientific | 2022 |
| Ryzara Ltd | Health & social care | 2026 |
| S & a Engineering Group Limited | Manufacturing | 2012 |
| S & B Digital Ltd | Information & communication | 2016 |
| S & C Leisure Limited | Other services | 2018 |
| S & K Gibson's Limited | Administrative & support | 2013 |
| S & K Industrial & Domestic Services Limited | Construction | 1992 |
| S & S Leasehold Ltd | Extraterritorial | 2025 |
| S &a Manufacturing Group Limited | Manufacturing | 2023 |
| S a Elite Group Limited | Wholesale & retail | 2021 |
| S a S Catering Limited | Hospitality | 2008 |
| S and S Decors Ltd | Wholesale & retail | 2024 |
| S B Payroll Services Limited | Professional & scientific | 2003 |
| S B Waste Solutions Limited | Water & waste | 2013 |
| S C Broomfield Company Limited | Real estate | 2024 |
| S C Broomfield Property Group Limited | Real estate | 2024 |
| S Collinson Transport Ltd | Transport & logistics | 2017 |
| S D C Consultancy Services Limited | Professional & scientific | 2008 |
| S E Robinson Ltd | Health & social care | 2009 |
| S Halton Air Conditioning Ltd | Energy | 2006 |
| S Henderson Engineering Limited | Professional & scientific | 2023 |
| S M E Building Ltd | Construction | 2026 |
| S Moran Ltd | Professional & scientific | 2022 |
| S P Professionals Limited | Health & social care | 2019 |
| S Pula Ltd. | Administrative & support | 2011 |
| S R Chaudhry Limited | Health & social care | 2024 |
| S W & C Jackson Limited | Health & social care | 2008 |
| S W Joiners Limited | Construction | 2015 |
| S Waterman Limited | Wholesale & retail | 2020 |
| S Whittle Limited | Manufacturing | 2020 |
| S&J Detailing Limited | Wholesale & retail | 2024 |
| S&R Homes Limited | Real estate | 2020 |
| S-Cube Technologies Ltd | Information & communication | 2022 |
| S. B. Barton Limited | Health & social care | 2015 |
| S. Burrows & Co. Limited | Professional & scientific | 2000 |
| S. Downes Builders Limited | Construction | 2002 |
| S. Grainger Limited | Administrative & support | 2016 |
| S.B Kirkland Limited | Professional & scientific | 2026 |
| S.Beckett Ltd | Manufacturing | 2018 |
| S.E.G. Developments Limited | Construction | 1951 |
| S.E.G. Homes and Construction Limited | Construction | 1959 |
| S.E.G. Investments Limited | Real estate | 1965 |
| S.J.Kavanagh Limited | Professional & scientific | 2015 |
| S.R.W. Garden Care Limited | Administrative & support | 2008 |
| S.Toothology Ltd | Health & social care | 2024 |
| S.Whitehead(Ironfounders)Limited | Manufacturing | 1950 |
| S2 Programme Solutions Ltd | Professional & scientific | 2025 |
| S2HEALTHCARE Ltd | Health & social care | 2015 |
| S2I3 Consultancy Limited | Information & communication | 2012 |
| S3 Digital Ltd | Information & communication | 2022 |
| S3 Fusion UK Limited | Professional & scientific | 2019 |
| S3 Homes Ltd | Real estate | 2020 |
| SA & Sons Trading Ltd | Wholesale & retail | 2020 |
| Saan Co UK Ltd | Wholesale & retail | 2001 |
| Saaspow Consultants Limited | Information & communication | 2012 |
| Saaz Properties Manchester Limited | Real estate | 2021 |
| Saaz Property Management Ltd | Real estate | 2025 |
| SAB Data Developments Limited | Administrative & support | 2015 |
| SAB Finance Limited | Professional & scientific | 2025 |
| Sabina Estates Group Holdings Limited | Real estate | 2015 |
| Sabina Estates Spain Limited | Real estate | 2021 |
| Sabir Healthcare Services Limited | Health & social care | 2016 |
| Sacks Properties Limited | Real estate | 2024 |
| Sadia Ltd | Health & social care | 2023 |
| Sadie Consulting Ltd | Professional & scientific | 2014 |
| Sadler's Park Management Company Limited | Households | 2006 |
| SAF Carbon Holdings Limited | Financial services | 2023 |
| SAF Sales Ltd | Wholesale & retail | 2025 |
| Safa Jannat Limited | Financial services | 2018 |
| Safa Noor Hasan Ltd | Wholesale & retail | 2022 |
| Safe GAS Services Limited | Other services | 2004 |