| DVN Monde Ltd | Construction | 2019 |
| DW INK Tattooist Limited | Professional & scientific | 2021 |
| DW Inspection (York) Limited | Construction | 2013 |
| DW Media Ltd | Professional & scientific | 2024 |
| Dwell on the Moor Ltd | Hospitality | 2023 |
| Dwellab Ltd. | Construction | 2016 |
| DWF Stocktaking Limited | Professional & scientific | 2003 |
| DWM Properties Yorkshire Limited | Real estate | 2024 |
| DWM Yorkshire Ltd | Real estate | 2019 |
| Dwom Limited | Agriculture & fishing | 2021 |
| DXN Surveyors Ltd | Real estate | 2022 |
| Dylans Barbers York Limited | Other services | 2020 |
| Dynaco Doors Limited | Extraterritorial | 2012 |
| Dynamic North Ltd | Professional & scientific | 2021 |
| Dynamiti Limited | Information & communication | 2021 |
| Dyslexia Bytes Ltd | Education | 2023 |
| Dysnfx Ltd | Information & communication | 2024 |
| E & L Retail Limited | Wholesale & retail | 2017 |
| E & W Property Investments Limited | Real estate | 2021 |
| E C Straiton & Partners Limited | Professional & scientific | 2009 |
| E Charge (Morley) Limited | Construction | 2023 |
| E H London Ltd | Administrative & support | 2021 |
| E J Telfer Ltd | Transport & logistics | 2026 |
| E K Barbe Q Limited | Hospitality | 2017 |
| E K Build Limited | Construction | 2012 |
| E O Tinson & Sons Ltd | Real estate | 2013 |
| E Price Plant & Agricultural Contracting Ltd | Construction | 2017 |
| E S Engineering Solutions Limited | Manufacturing | 2010 |
| E S Ventures Ltd | Professional & scientific | 2026 |
| E Tepe Limited | Other services | 2020 |
| E&C Property Rentals Ltd | Real estate | 2021 |
| E&L Fairy's Ltd | Administrative & support | 2023 |
| E&T Trinity Partnership LLP | | 2023 |
| E-Com Save Limited | Financial services | 2014 |
| E-Drive (PLM) Limited | Other services | 2024 |
| E-Drive Logistics (UK) Limited | Transport & logistics | 2020 |
| E-Sculpting Ltd | Wholesale & retail | 2021 |
| E. Kendall & Sons Limited | Manufacturing | 2000 |
| E. M. & S. Limited | Construction | 2000 |
| E.B Property and Landscaping Limited | Construction | 2024 |
| E.D.W. Controls Ltd. | Professional & scientific | 1994 |
| E.E. Reed & Co. (Builders) Limited | Professional & scientific | 1959 |
| E.F.G.H. Limited | Extraterritorial | 1977 |
| E.F.G.H. Nominees Limited | Extraterritorial | 1986 |
| E.G. Architects Ltd | Professional & scientific | 2023 |
| E3 Primus Invest UK Bidco Limited | Financial services | 2024 |
| E3 Primus Invest UK Limited | Professional & scientific | 2024 |
| EA Student Lettings Ltd | Real estate | 2014 |
| Eagle 2026 Bidco Limited | Financial services | 2026 |
| Eagle 2026 Midco Limited | Financial services | 2026 |
| Eagle 2026 Topco Limited | Financial services | 2026 |
| Eagle Digital Ltd | Information & communication | 2015 |
| Eagle Wellness Ltd | Other services | 2025 |
| Ealdwic Estate Limited | Real estate | 2023 |
| EAM Developments Garboldisham 2021 Ltd | Construction | 2021 |
| Eamonn Byrne Landscape Architects Ltd | Professional & scientific | 2018 |
| Eamy Ltd | Real estate | 2023 |
| Earase Ltd | Health & social care | 2024 |
| Earl and Rymer Ltd | Wholesale & retail | 2017 |
| Earlesmead (Framingham Earl) Residents Management Company Limited | Households | 2015 |
| Earlston Farms Limited | Real estate | 2023 |
| Earnie's Customs Ltd | Manufacturing | 2020 |
| Earth and Elements Jewellery Ltd | Wholesale & retail | 2020 |
| Earth Arts Ltd | Wholesale & retail | 2025 |
| Earth Life Ltd | Health & social care | 2024 |
| Earth Treds Ltd | Manufacturing | 2023 |
| Earth Village C.I.C. | Professional & scientific | 2021 |
| Earthbound Incorporated Ltd | Financial services | 2023 |
| Earthbound Scientific Ltd | Manufacturing | 2020 |
| Earthen Limited | Wholesale & retail | 2019 |
| Earthmover Tyre Recycling Ltd | Construction | 2024 |
| Earthmover Tyre Solutions Limited | Construction | 2008 |
| Earworm Records York Ltd | Wholesale & retail | 2019 |
| Easicleans York Limited | Administrative & support | 2021 |
| Easilets Limited | Real estate | 2023 |
| Easingwold Chickens Limited | Real estate | 1972 |
| Easingwold Cricket Club Limited | Arts & recreation | 2025 |
| Easingwold Golf Centre Ltd | Arts & recreation | 2017 |
| Easingwold Golf Club Limited | Arts & recreation | 2022 |
| Easingwold Property Developments Limited | Construction | 2018 |
| East Avenue Ltd | Wholesale & retail | 2020 |
| East Benton Rise (Benton) Management Company Limited | Real estate | 2016 |
| East Coast Gyrocopters Ltd | Other services | 2020 |
| East Coast Health Options Community Interest Company | Health & social care | 2008 |
| East Coast Travel Limited | Transport & logistics | 2007 |
| East Parade PO Ltd | Transport & logistics | 2017 |
| East Park Lets Limited | Real estate | 2020 |
| East Riding Business Services Ltd | Professional & scientific | 2006 |
| East Riding Commercials Ltd | Wholesale & retail | 2025 |
| East Riding Holdings Company | Financial services | 1987 |
| East Riding Home Care Limited | Health & social care | 2023 |
| East Riding Horticulture Limited | Agriculture & fishing | 1989 |
| East Riding Motors Limited | Wholesale & retail | 1995 |
| East Riding Office Services Ltd. | Professional & scientific | 2014 |
| East Riding Renewables Ltd | Construction | 2021 |
| East Riding Sack and Paper Co. Limited | Extraterritorial | 1970 |
| East Riding Sacks Limited | Manufacturing | 1987 |
| East Rudland Construction Ltd | Construction | 2017 |
| East Yorkshire Commercials Ltd. | Wholesale & retail | 2007 |
| East Yorkshire Direct Cremations Ltd | Other services | 2026 |