| Dorchester Care Homes Limited | Health & social care | 2023 |
| Dorchester Healthcare 1 Limited | Health & social care | 2025 |
| Dorchester Healthcare Holding Limited | Financial services | 2025 |
| Dorchester Property 1 Limited | Real estate | 2025 |
| Dorian Marine Ltd | Wholesale & retail | 2021 |
| Dorothy Goes Glamping Ltd | Hospitality | 2020 |
| Dorset and Somerset Property Ltd | Construction | 2019 |
| Dorset Deli Ltd | Administrative & support | 2010 |
| Dorset Sauce Company Ltd | Manufacturing | 2021 |
| DOT Properties Limited | Transport & logistics | 2017 |
| Double YEW Property Limited | Real estate | 2021 |
| Downyard Residents Association Limited | Households | 1997 |
| DP Bevington Consultancy Ltd | Professional & scientific | 2016 |
| DR Kmatic Health & Wellbeing Limited | Wholesale & retail | 2023 |
| DR Marius Borcea Anaesthetics Ltd | Health & social care | 2015 |
| Dromana Developments Ltd | Real estate | 2012 |
| DT9 Brewing Ltd | Financial services | 2023 |
| DT9 Group Limited | Financial services | 2022 |
| DT9 Holdings Limited | Financial services | 2026 |
| Dual Strength Coaching Ltd | Education | 2026 |
| Duffields (South West) Limited | Manufacturing | 1992 |
| Duffields Hautbois Farms Limited | Agriculture & fishing | 1962 |
| Duffields Mills Limited | Manufacturing | 1962 |
| Durleigh Property Investments | Real estate | 1962 |
| Durweston Farms Limited | Agriculture & fishing | 1976 |
| Dust TIL Dawn Cleaning Solutions Ltd | Administrative & support | 2022 |
| Dyeovil SUB Ltd | Hospitality | 2024 |
| Dyers Metal Mesh Limited | Wholesale & retail | 2002 |
| Dyers Property Ltd | Real estate | 2023 |
| Dynamic Dairying Limited | Agriculture & fishing | 2013 |
| Dynamic Diagnostics Ltd | Manufacturing | 2021 |
| Dædalus Historic Building Repair Ltd | Extraterritorial | 2016 |
| E & B Law Associates Limited | Professional & scientific | 2015 |
| E B Marine Ltd | Professional & scientific | 2013 |
| E G Harding Ltd | Construction | 2015 |
| E J Badman & SON Limited | Agriculture & fishing | 2014 |
| E J Webb & SON Limited | Agriculture & fishing | 2018 |
| E-Glen Projects Limited | Professional & scientific | 2008 |
| E-Volve Estate Agents Limited | Real estate | 2014 |
| E.& K.Bartlett Limited | Transport & logistics | 1962 |
| Eagle Buisness Travels Ltd | Transport & logistics | 2024 |
| Earle Street Yeovil Ltd | Real estate | 2023 |
| Eastbury House (Sherborne) Limited | Health & social care | 2003 |
| Eastdene Limited | Real estate | 2000 |
| Eastville Project Ltd | Arts & recreation | 2020 |
| Eastville Project Space Limited | Arts & recreation | 2016 |
| Easyflow Plumbing & Heating Limited | Construction | 2023 |
| EC Creations Ltd | Arts & recreation | 2022 |
| EC2 Developments Limited | Construction | 2016 |
| Eden Motors Limited | Wholesale & retail | 2005 |
| Edge Inc Limited | Construction | 2015 |
| Editit Ltd | Information & communication | 2023 |
| Edvantage Psychology Limited | Education | 2025 |
| Edward Verity Limited | Professional & scientific | 2012 |
| Efde Consulting Limited | Professional & scientific | 2019 |
| EFJ Services Limited | Real estate | 2024 |
| Egan Fire Safety Limited | Financial services | 2023 |
| EGG2024 Limited | Administrative & support | 2024 |
| Eggle Consulting Limited | Professional & scientific | 2018 |
| Ehealth Learning Limited | Health & social care | 2015 |
| Ehomemove Ltd | Real estate | 2013 |
| EJK Carpentry Ltd | Construction | 2026 |
| Ekmai Technologies Ltd | Information & communication | 2001 |
| EL ROI Estates Limited | Real estate | 2025 |
| EL ROI Ltd | Administrative & support | 2025 |
| Elbouni Limited | Real estate | 2024 |
| Electrical Installation Design Services Ltd | Professional & scientific | 2012 |
| Electrical Solutions SW Ltd | Administrative & support | 2011 |
| Elegance Foods Limited | Wholesale & retail | 2020 |
| Element Ventures Ltd | Real estate | 2025 |
| Elevate Physio Ltd | Health & social care | 2015 |
| Elevate Scaffolding SW Limited | Construction | 2025 |
| Elite Electrix Limited | Manufacturing | 2000 |
| Elite Exteriors Southwest Ltd | Construction | 2026 |
| Elite PMR Limited | Manufacturing | 2025 |
| Elite Racing and Driving Limited | Arts & recreation | 2018 |
| Ella Wahlstrom Sound Design Limited | Arts & recreation | 2024 |
| Ellemy Ltd | Wholesale & retail | 2013 |
| Ellen Ayres Haulage Ltd | Transport & logistics | 2025 |
| Elliscombe Farm Limited | Agriculture & fishing | 2017 |
| Elmleigh Associates Limited | Professional & scientific | 2012 |
| Elmleigh Property Management Ltd | Real estate | 2024 |
| Elodie Investments Ltd | Financial services | 2025 |
| Elvet Software Limited | Information & communication | 2015 |
| Emco Business Services Ltd | Professional & scientific | 2012 |
| Emerald First AID Training Ltd | Education | 2018 |
| Emily Duchscherer Kirk Studio Ltd | Education | 2026 |
| Eminaj Limited | Health & social care | 2025 |
| Eminence Dance Academy Ltd | Education | 2025 |
| EMO Angel Ltd | Transport & logistics | 2023 |
| Empire Building and Roofing SW Ltd | Construction | 2026 |
| EMR Business Management Ltd | Professional & scientific | 2020 |
| Emtech Hatchery Systems Ltd | Manufacturing | 2014 |
| Emtech International Ltd | Manufacturing | 2023 |
| Enable Support Services Ltd | Health & social care | 2008 |
| Enginata Ltd | Information & communication | 2024 |
| Enhanced Recovery After Surgery Society (UK) C.I.C. | Administrative & support | 2017 |
| Enlightened Electrics Ltd | Construction | 2025 |
| Enron Real Estate Limited | Real estate | 2021 |
| Environmental-Ex Ltd | Professional & scientific | 2025 |