| Sandstone Poultry Ltd | Agriculture & fishing | 2022 |
| Sandwich and Salad Bar Limited | Hospitality | 2021 |
| Saneller Limited | Other services | 2003 |
| Sanlock Electrical Limited | Construction | 2024 |
| SAP Building&Landscaping Ltd | Construction | 2024 |
| Saplings (Wrexham) Limited | Health & social care | 2004 |
| Sapor Enterprises Limited | Professional & scientific | 2008 |
| Sarah Stopforth Ltd | Wholesale & retail | 2021 |
| SAT- BIT Limited | Construction | 2017 |
| Satiro A.I Limited | Information & communication | 2024 |
| Saunas 4YOU Ltd | Construction | 2017 |
| Sausage Cottage Rentals Ltd | Hospitality | 2023 |
| Savill Birch Limited | Professional & scientific | 2022 |
| Sayos Gakki Studio Ltd | Professional & scientific | 2026 |
| SB Materials UK Ltd | Wholesale & retail | 2017 |
| SBM Wrexham Properties Limited | Households | 2023 |
| SC Inns Ltd | Hospitality | 2024 |
| Scales Consultancy Limited | Professional & scientific | 2013 |
| Scape Ground Construction Limited | Construction | 2019 |
| Scdeals Ltd | Wholesale & retail | 2025 |
| Scdocumentation Ltd | Agriculture & fishing | 2019 |
| Schedlix Ltd | Information & communication | 2025 |
| School Mews 1970 Limited | Extraterritorial | 2014 |
| Scidekick Ltd | Education | 2023 |
| Scott D Smith Limited | Professional & scientific | 2012 |
| Scoutdeck Ltd | Information & communication | 2025 |
| Scpm Limited | Construction | 2007 |
| SCR Property Ltd | Real estate | 2025 |
| Scrabo Limited | Real estate | 2021 |
| SD Consulting (NW) Ltd | Professional & scientific | 2017 |
| SD PUB Group Ltd | Hospitality | 2025 |
| SD Solutions Group Limited | Construction | 2025 |
| SDG Trading Limited | Wholesale & retail | 2005 |
| SDJ Groundworks Ltd | Construction | 2020 |
| SDM Leisure Limited | Wholesale & retail | 2023 |
| Sealand Road Management Co. Ltd | Households | 2026 |
| Search & Convey Limited | Professional & scientific | 2025 |
| Seaside Leisure Group Limited | Hospitality | 2025 |
| Seasond CYF | Information & communication | 2026 |
| Sebastian Salas Studio Ltd | Administrative & support | 2020 |
| Sebavier Ltd | Construction | 2026 |
| Sebchia Holdings Limited | Financial services | 2025 |
| Sebx Ltd | Wholesale & retail | 2024 |
| Second Circle Furniture Recycling Centre Ltd | Water & waste | 2006 |
| Secret Spa Holt Ltd | Other services | 2014 |
| Sectorsmart Ltd | Information & communication | 2026 |
| Secure Caravan Storage Limited | Hospitality | 2014 |
| Secure Storage Sites Ltd | Real estate | 2018 |
| Security England Ltd. | Extraterritorial | 2007 |
| SEE Beyond the Numbers Ltd | Professional & scientific | 2018 |
| Select Colours Limited | Professional & scientific | 2008 |
| Self Storage Containers Limited | Administrative & support | 2021 |
| Sellalot Ltd | Wholesale & retail | 2025 |
| Sellers Ltd | Other services | 2022 |
| Sellkrit Ltd | Construction | 2007 |
| Semper Plastering Limited | Construction | 2017 |
| Sentinel Environmental Consultancy Limited | Professional & scientific | 2017 |
| Sentrix Ltd | Information & communication | 2025 |
| SEO4TRADESMEN Limited | Professional & scientific | 2021 |
| Sercus Limited | Wholesale & retail | 2011 |
| SET Square Investments Limited | Financial services | 2025 |
| Setchfield Cycles Ltd | Administrative & support | 2013 |
| Seths Cafe Limited | Hospitality | 2026 |
| Seton Technical Solutions Limited | Professional & scientific | 2023 |
| Sewing Machine Exchange Limited | Extraterritorial | 2016 |
| Sewing Machines Direct Limited | Extraterritorial | 2016 |
| Sewing Machines Limited | Extraterritorial | 2015 |
| SFL Property Limited | Real estate | 2019 |
| SG Automotives Limited | Manufacturing | 2015 |
| SGG Agricultural Services Limited | Manufacturing | 2016 |
| SGG Joinery Services Ltd | Construction | 2025 |
| SH & IH Partnership Limited | Professional & scientific | 2019 |
| Shahzad Caterers Ltd | Hospitality | 2022 |
| Shannon Engineering Services Ltd | Construction | 2007 |
| Shareprophets Ltd | Other services | 2013 |
| Shark Bait Socials Ltd | Professional & scientific | 2021 |
| Shark Bite Pro Ltd | Manufacturing | 2026 |
| Shawflow Services Limited | Administrative & support | 2025 |
| Shear Gardens Landscaping Ltd | Administrative & support | 2009 |
| Sheila and Chezhian's Properties Limited | Real estate | 2011 |
| Shepy Developments Limited | Construction | 2024 |
| Sheq-Sol Ltd | Professional & scientific | 2021 |
| Sherlock Foams Limited | Manufacturing | 1987 |
| Shining Edge Ltd | Information & communication | 2015 |
| Ship Happens-Uk Ltd | Information & communication | 2025 |
| Shivam Clinical Limited | Health & social care | 2019 |
| Shones Homes Limited | Real estate | 2021 |
| Shop 34 Regent Street Ltd | Information & communication | 2025 |
| Shop Snappy Ltd | Wholesale & retail | 2025 |
| SHOPWALK3D.COM Limited | Information & communication | 2014 |
| Shordley Services Ltd | Professional & scientific | 2010 |
| Shot Aviation Ltd | Manufacturing | 2017 |
| Shotwick Ltd | Wholesale & retail | 2024 |
| Shoulder-Shoulder CIC | Information & communication | 2025 |
| Shropshire Estate Agents Ltd | Real estate | 2024 |
| Shumba Properties Limited | Real estate | 2026 |
| Signature Finish Ltd | Construction | 2026 |
| Signature Property Ltd | Real estate | 2025 |
| Signature Styled Tiling Ltd | Construction | 2026 |
| Silent Yeti Entertainment Ltd | Information & communication | 2020 |