| RRC Group Limited | Administrative & support | 2015 |
| RRP Properties Limited | Real estate | 2019 |
| RRS NW Limited | Manufacturing | 2023 |
| RSC NW Ltd | Professional & scientific | 2023 |
| RSM Training and Assessing Services Limited | Education | 2018 |
| Ruabon Resources Ltd | Extraterritorial | 2013 |
| Ruabon Road Properties Limited | Construction | 2017 |
| Ruabon Sales Limited | Wholesale & retail | 2008 |
| Ruabon Turkish Barbers Ltd | Other services | 2026 |
| Rubbercover Limited | Construction | 2007 |
| Rugged Mobile Systems Ltd | Information & communication | 2007 |
| Rugged Reach Services Ltd | Administrative & support | 2026 |
| Rural & Commercial Finance Ltd | Financial services | 2017 |
| Rural Associates Limited | Financial services | 2008 |
| Rural Finance Limited | Financial services | 2004 |
| Rural Finance Technologies Limited | Information & communication | 2025 |
| Russ Transport Limited | Transport & logistics | 2014 |
| Rustik Woodcrafted Ltd | Wholesale & retail | 2023 |
| RV Agriship Limited | Transport & logistics | 2015 |
| RV Shipping Ltd | Transport & logistics | 2008 |
| RWC Group Incorporated Ltd | Administrative & support | 2018 |
| RWD Demolition Limited | Construction | 2019 |
| RX Focused Ltd | Administrative & support | 2026 |
| Ryecroft Meadow Limited | Real estate | 2025 |
| Ryzen Trading Ltd | Wholesale & retail | 2022 |
| S & K Mathews (Wrexham) Limited | Other services | 2023 |
| S & L (Wrexham) Holdings Limited | Financial services | 2023 |
| S & N Beauty T/A Beauty Zone Ltd | Other services | 2017 |
| S & R Developments (North Wales) Limited | Construction | 2010 |
| S & T Property Developments Ltd | Construction | 2018 |
| S & T Systems Ltd | Manufacturing | 2005 |
| S a Bannister Limited | Professional & scientific | 2021 |
| S a Roberts Groundworks Limited | Construction | 1999 |
| S Baldam Financial Services Ltd | Financial services | 2024 |
| S C Commercials Ltd | Wholesale & retail | 2023 |
| S C Van & Truck Ltd | Wholesale & retail | 2024 |
| S G Estates Group Ltd | Extraterritorial | 2018 |
| S G Estates Ltd | Construction | 2004 |
| S J Bebbington Butchers Ltd | Hospitality | 2011 |
| S J H Construction Limited | Construction | 2016 |
| S J Stone Security Services Ltd | Administrative & support | 2025 |
| S Jones Groundworks Ltd | Construction | 2018 |
| S M a Y S (UK) Ltd | Hospitality | 2010 |
| S M Locum Consultants Ltd | Wholesale & retail | 2016 |
| S O'Sullivan Holdings Ltd | Financial services | 2025 |
| S P & I Management Limited | Professional & scientific | 2007 |
| S R Machin (Cloy Hall) Limited | Real estate | 2003 |
| S Totev Transport Ltd | Transport & logistics | 2018 |
| S W Heating Services Limited | Construction | 2007 |
| S&C Trading Limited | Manufacturing | 2022 |
| S&G Power Management Services Limited | Other services | 2017 |
| S&K Mathews (WXM) Ltd | Water & waste | 2026 |
| S&L Aerospace Engineering Ltd | Professional & scientific | 2019 |
| S&L Allman Ltd | Hospitality | 2023 |
| S&P Estates Ltd | Real estate | 2016 |
| S&S Electrical & Security Limited | Construction | 2020 |
| S. Beech Builders Ltd | Construction | 2007 |
| S. Fagan GAS Services Ltd | Construction | 2010 |
| S. L. Plumbing Limited | Construction | 2008 |
| S.A.W. Electrical Services Ltd | Construction | 2018 |
| S.D.R Groundworks Ltd | Construction | 2019 |
| S.K.J Fast Food Ltd | Hospitality | 2018 |
| S.M. Shepherd C.V.R. Ltd | Wholesale & retail | 2021 |
| SA Sweets Ltd | Wholesale & retail | 2025 |
| SA Tech Innovations Ltd | Information & communication | 2026 |
| Saannie Medical Services Limited | Health & social care | 2014 |
| SAB Wrexham Ltd | Hospitality | 2017 |
| Sabor DE Amor Limited | Manufacturing | 2018 |
| Sabre Trading (Wrexham) Ltd | Hospitality | 2013 |
| Sackville Consultants Limited | Construction | 2016 |
| Sadler Fitness Limited | Arts & recreation | 2007 |
| Saenco Workspace Limited | Administrative & support | 2007 |
| SAF Systems Limited | Professional & scientific | 2010 |
| Safe Aqua Limited | Water & waste | 2016 |
| Safepath Medical Ltd | Education | 2015 |
| Safeway Scaffolding (North West) Limited | Construction | 2008 |
| Saffcor Courier Ltd | Transport & logistics | 2025 |
| Sagar Design Services Ltd | Other services | 2008 |
| Sage at Conwy Limited | Wholesale & retail | 2010 |
| Sage Civils Limited | Construction | 2021 |
| SAI Candid Services Limited | Wholesale & retail | 2014 |
| Saint Minerals UK Limited | Wholesale & retail | 2023 |
| Salisbury Media Group Ltd | Professional & scientific | 2024 |
| Salomon Properties Limited | Real estate | 2015 |
| Salon LA (Wrexham) Limited | Other services | 2017 |
| Salon LA Academy Limited | Other services | 2025 |
| Salon One 20 Limited | Other services | 2008 |
| Salon Xcel Limited | Other services | 2003 |
| Salons First Limited | Other services | 2009 |
| Salonspy Limited | Information & communication | 2012 |
| Salop 1969 Limited | Extraterritorial | 2013 |
| Salus Associates Limited | Professional & scientific | 2024 |
| SAM Baldam Limited | Financial services | 2018 |
| Samarth and Ananya Ltd | Real estate | 2019 |
| Samruddhi Ltd | Real estate | 2022 |
| Samruddhi Medicare Ltd | Health & social care | 2023 |
| Sandee Worldwide Limited | Wholesale & retail | 2013 |
| Sanderson Procurement Services Limited | Professional & scientific | 2025 |
| Sandringham Properties (WXM) Ltd | Construction | 2024 |
| Sandstone Brewery Ltd | Manufacturing | 2013 |