| Drift Touring Ltd | Hospitality | 2025 |
| Driftlodge Limited | Administrative & support | 2006 |
| Drink Childish Ltd | Manufacturing | 2025 |
| Drink Events Ltd | Extraterritorial | 2019 |
| Driptrip Limited | Wholesale & retail | 2018 |
| Drive Thru Coffee Limited | Hospitality | 2025 |
| Drive Thru Snacks Ltd | Hospitality | 2024 |
| Driverstation Ltd | Education | 2025 |
| Driving Instructor Cars Ltd | Administrative & support | 2025 |
| DRK Sussex Limited | Real estate | 2018 |
| Dropfoot Design Ltd | Professional & scientific | 2019 |
| DRU Designs Ltd | Professional & scientific | 2018 |
| Drummond Court Worthing Limited | Households | 2018 |
| Druryway 250 Limited | Extraterritorial | 1919 |
| Druryway One Limited | Extraterritorial | 1926 |
| Druryway P & S Limited | Manufacturing | 1949 |
| Druryway PSE Limited | Professional & scientific | 1929 |
| Druryway Samba Limited | Professional & scientific | 1935 |
| DS Fernandes Ltd | Real estate | 2023 |
| DSH Construction Limited | Construction | 2025 |
| Dsopa Elite Programme Limited | Arts & recreation | 2026 |
| DSP Financial Planning Ltd | Financial services | 2014 |
| DT Finance Ltd | Professional & scientific | 2017 |
| DT Premier International Ltd | Professional & scientific | 2026 |
| DTK Roofing Solutions Ltd | Construction | 2026 |
| Dtzg Consulting Ltd | Administrative & support | 2023 |
| DUA & Hawa Ltd | Hospitality | 2025 |
| Dualrose Limited | Real estate | 2000 |
| Duckcorp Ltd | Administrative & support | 2002 |
| Duddings Limited | Hospitality | 2025 |
| Dudes Barber Limited | Other services | 2024 |
| Dugard Consultancy Services Ltd | Information & communication | 2019 |
| Duke Street Properties (Brighton) Limited | Real estate | 1961 |
| Dukia Property Management Co.Limited | Households | 1969 |
| Dumb Blonde Hair Studio Ltd | Other services | 2020 |
| Duncan Heath Digital Marketing Limited | Information & communication | 2021 |
| Dunkerton’S Plumbing & Heating Ltd | Construction | 2010 |
| Dunkley's of Deal Limited | Wholesale & retail | 2006 |
| Dunntech Limited | Information & communication | 2013 |
| Dunya International Supermarket Ltd | Wholesale & retail | 2026 |
| DUO Hosting Ltd | Administrative & support | 2023 |
| Durham Software Limited | Information & communication | 1997 |
| Durrington Community Cycle Project C.I.C. | Manufacturing | 2018 |
| Durrington Hill Management Company Limited | Households | 2004 |
| Durrington Multi Academy Trust | Education | 2014 |
| Durston Property Group Ltd | Real estate | 2025 |
| Dustsentinel Environmental Systems Limited | Water & waste | 2026 |
| Dutton Cars Ltd | Administrative & support | 2017 |
| Duty Doctor Limited | Information & communication | 2018 |
| DUX Solutions Ltd | Professional & scientific | 2025 |
| Dwellbuild Ltd | Construction | 2025 |
| Dwelledge Properties Rentals Ltd | Real estate | 2024 |
| DWG Games Limited | Information & communication | 2023 |
| DX Futures Ltd | Other services | 2019 |
| DXT LE Ltd | Administrative & support | 2016 |
| Dyerflyer Limited | Information & communication | 2013 |
| Dylo Ventures Limited | Real estate | 2016 |
| Dymond Jewellery Limited | Manufacturing | 2023 |
| Dynamic Global Village Limited | Construction | 2016 |
| Dynex Technologies Europe Limited | Health & social care | 2002 |
| Dyzio Limited | Information & communication | 2015 |
| E & T Events and Hospitality Ltd | Arts & recreation | 2021 |
| E B Digging Ltd | Construction | 2021 |
| E J White Limited | Professional & scientific | 2001 |
| E Mura Ltd | Administrative & support | 2022 |
| E&F Holdings Limited | Health & social care | 2024 |
| E-Focus Limited | Professional & scientific | 2000 |
| E-Transfer Technologies (UK) Limited | Information & communication | 2026 |
| E. Street Restaurants Limited | Hospitality | 2010 |
| E.I.S. Industrial Supplies Limited | Wholesale & retail | 2005 |
| E.P.A. Properties Limited | Real estate | 2022 |
| E2B Brickwork Ltd | Construction | 2024 |
| EA Bedford Limited | Hospitality | 2016 |
| EA Northampton Limited | Hospitality | 2016 |
| EA Robinson Properties Ltd | Real estate | 2018 |
| Eagle Executive Search Ltd | Administrative & support | 2025 |
| Eagles Spearing Management Consultancy Limited | Professional & scientific | 2021 |
| Earls Construction Limited | Construction | 2026 |
| Earnscliffe Davies Associates Ltd | Professional & scientific | 2005 |
| Earth Private Holdings Ltd | Financial services | 2021 |
| Earth's Health Care Limited | Administrative & support | 2021 |
| Earthmoss Investments Ltd | Administrative & support | 2018 |
| Eason Adams Properties Ltd | Real estate | 2017 |
| East Coast Property Investment Limited | Real estate | 2018 |
| East Sussex Property Ltd | Real estate | 2025 |
| East Worthing Site Services Limited | Construction | 2021 |
| East-Med Estates Ltd | Real estate | 2006 |
| Eastlands Equestrian Ltd | Administrative & support | 2002 |
| Eastlands Farm Ltd | Construction | 1999 |
| Eastrise Group Limited | Professional & scientific | 2024 |
| Easy Solutions Building Ltd | Construction | 2007 |
| Easy Taxi (Sussex) Ltd | Transport & logistics | 2019 |
| Easyncr Ltd | Manufacturing | 2013 |
| Easythaiger Ltd | Hospitality | 2025 |
| Eate Ltd | Information & communication | 2020 |
| Eatl Group Covenantors Limited | Financial services | 2017 |
| EB10 Limited | Real estate | 2021 |
| EBB Restaurant Ltd | Hospitality | 2026 |
| EBR Electrical Limited | Construction | 2018 |
| EC Food and Wine Limited | Hospitality | 2024 |