| Solar Power Investments (1) Limited | Administrative & support | 2011 |
| Sole Sisters Fashion Ltd | Wholesale & retail | 2025 |
| Solery Software Ltd | Information & communication | 2020 |
| Solex Industries Limited | Professional & scientific | 2021 |
| Soluna Spaces Ltd | Financial services | 2025 |
| Soluna Stays Ltd | Real estate | 2025 |
| Solus Testing Limited | Construction | 1999 |
| Solved Digital Limited | Professional & scientific | 2021 |
| Soul Architects Limited | Professional & scientific | 2009 |
| Soundbite UK Events and Media Ltd | Arts & recreation | 2019 |
| Sounding Board LC Ltd | Information & communication | 2024 |
| South Carlton Motors Limited | Wholesale & retail | 2008 |
| Southfield Engineering & Calibration Services Limited | Manufacturing | 2002 |
| Sovereign Marine Limited | Transport & logistics | 2026 |
| Spark Trans Ltd | Construction | 2022 |
| Sparken Hill Academy Trust | Education | 2014 |
| Sparkles Beauty Supplies Limited | Wholesale & retail | 2022 |
| Sparky's Mate Limited | Wholesale & retail | 2017 |
| SPD Global Limited | Wholesale & retail | 2025 |
| Special One Barber Limited | Other services | 2024 |
| Specialist Fight Management Ltd | Arts & recreation | 2025 |
| Spectrumsoft Ltd | Information & communication | 2025 |
| Spici Limited | Extraterritorial | 2009 |
| Spiddle Ltd | Information & communication | 2025 |
| Spizo International Ltd | Wholesale & retail | 2026 |
| Sportpower Limited | Administrative & support | 2005 |
| Sportsys LLP | | 2015 |
| Sprint Vehicle Movements Ltd | Transport & logistics | 2020 |
| SPRINT67 Ltd | Information & communication | 2023 |
| Squid INK Detailing Ltd | Manufacturing | 2018 |
| Squirrel Construction Limited | Construction | 2003 |
| SR Exploranza Limited | Other services | 2021 |
| SRM Financial Planning Ltd | Professional & scientific | 2011 |
| ST Angels Ltd | Wholesale & retail | 2024 |
| ST Clair Steel Limited | Wholesale & retail | 2019 |
| ST John Coutts Limited | Information & communication | 2024 |
| ST. Antony's Care Ltd. | Health & social care | 2015 |
| Stage Instruct Ltd | Education | 2024 |
| Stanciu Transport Ltd | Transport & logistics | 2018 |
| Standtu Global Training Ltd | Education | 2024 |
| Stanfield Management Services LLP | | 2023 |
| Stansbury Consulting Ltd | Financial services | 2025 |
| Stapletons Lock & Safe Limited | Other services | 2008 |
| Star Barber Bridge Place Limited | Other services | 2024 |
| Starpour Ltd | Wholesale & retail | 2022 |
| Staytuned Hospitality Ltd | Information & communication | 2025 |
| Steamforce Cleaning Ltd | Administrative & support | 2025 |
| Steetley Dolomite Limited | Manufacturing | 2000 |
| Stephen Kimpton Ltd | Transport & logistics | 2014 |
| Sterling Electrical Services (Yorkshire) Ltd | Construction | 2016 |
| Stevenson Hair Limited | Other services | 2000 |
| Stick & Steam Ltd | Hospitality | 2025 |
| Stimco Limited | Administrative & support | 2010 |
| Stirland Solutions Ltd | Education | 2023 |
| Stitches (Worksop) Ltd | Manufacturing | 2020 |
| Stone Haulage Limited | Transport & logistics | 2022 |
| Stonemoore Plumbing and Heating Limited | Construction | 2025 |
| Stop and Shop Market Ltd | Wholesale & retail | 2024 |
| Story Beauty Ltd | Other services | 2024 |
| Storycatchers Limited | Professional & scientific | 2013 |
| Stratify TAG Markets Sonic AI Investment Incorporation Ltd | Financial services | 2026 |
| Stratosphere Aero ENG Ltd | Manufacturing | 2025 |
| STS Freight Solution Ltd | Construction | 2023 |
| STS Retail Consulting Ltd | Extraterritorial | 2011 |
| Stunningly Clean Ltd | Administrative & support | 2025 |
| Su&Sa Ltd | Wholesale & retail | 2022 |
| Suburban Style Limited | Real estate | 2025 |
| Sueamy Park Limited | Hospitality | 2015 |
| Sugar Free Tech Ltd | Information & communication | 2025 |
| Sunlight Nutrition Limited | Health & social care | 2017 |
| Sunnar and Khaira Limited | Financial services | 2013 |
| Sunnar and Pamma Limited | Financial services | 2013 |
| Sunnyside Consultants Ltd | Professional & scientific | 2023 |
| Superpets (Worksop) Ltd | Wholesale & retail | 2021 |
| Sure Fit Conservatories UK Ltd | Construction | 2021 |
| Sure Fit Fabrications Ltd | Manufacturing | 2022 |
| Surebase-North Ltd | Construction | 2025 |
| Suskun Ltd | Hospitality | 2025 |
| Sutherland House (Trading) Limited | Education | 1997 |
| SUV OIL Limited | Wholesale & retail | 2025 |
| Suveeni Property Limited | Real estate | 2020 |
| Swan Inn Worksop Limited | Hospitality | 2025 |
| Sweeney's Baber Shop Ltd | Other services | 2025 |
| Synergy Installs Ltd | Construction | 2023 |
| Synergy Leisure Ltd | Arts & recreation | 2021 |
| T & J PUB Company Limited | Hospitality | 2019 |
| T 2 Hive Limited | Information & communication | 2012 |
| T Baddiley & Sons Limited | Agriculture & fishing | 1956 |
| T C H Joinery Limited | Construction | 2006 |
| T D Site Solutions Limited | Professional & scientific | 2015 |
| T K Inn Ltd | Hospitality | 2016 |
| T Moore Ltd | Wholesale & retail | 2022 |
| T Phipps Construction Services Limited | Construction | 2014 |
| T Sunnar & S Sunnar Limited | Health & social care | 2018 |
| T W Jeffery Building Contractors Limited | Construction | 2019 |
| T.G.S Tree & Gardening Services Ltd | Administrative & support | 2022 |
| T.Z. Car-Motor Ltd | Extraterritorial | 2022 |
| T2 Design Solutions Limited | Information & communication | 2007 |
| T4 4SWA Healthcare Ltd | Health & social care | 2026 |
| Tabularius Limited | Professional & scientific | 2015 |