| Searchflex Ltd | Information & communication | 2025 |
| Sebstan Ltd | Real estate | 2025 |
| Secure Perception Research Ltd | Professional & scientific | 2009 |
| Securetranspologistics Limited | Transport & logistics | 2026 |
| Select Scales Limited | Manufacturing | 2002 |
| Sellec Limited | Manufacturing | 2014 |
| Senaldo Company Ltd | Real estate | 2019 |
| Senatek Recruitment Limited | Other services | 2025 |
| Senior MAN Ltd | Health & social care | 2025 |
| Senni Projects Ltd | Professional & scientific | 2022 |
| Senni Property Holdings Ltd | Real estate | 2024 |
| Sentinel Rail Projects Ltd | Construction | 2025 |
| Serenity Home Rentals Limited | Real estate | 2021 |
| Server Switch Ltd | Wholesale & retail | 2019 |
| Servernation Limited | Information & communication | 2007 |
| Service 2000 Machine Tools Limited | Manufacturing | 2011 |
| Sesame Cafe Limited | Hospitality | 2025 |
| Seven Hills Property Developments Ltd | Real estate | 2022 |
| Seventeen Thirteen Ltd | Information & communication | 2026 |
| SG Fit Coaching Ltd | Education | 2025 |
| SGR Properties (Derbyshire) Ltd | Real estate | 2022 |
| Shajc Ltd | Wholesale & retail | 2020 |
| Shalles Home Care Limited | Administrative & support | 2022 |
| Shandy's Property Ltd | Real estate | 2024 |
| Sharkeye Wheel Alignment Centres UK Ltd | Wholesale & retail | 2021 |
| Shed Shed Sheds Limited | Construction | 2004 |
| Sheldaire Technology Ltd | Information & communication | 2015 |
| Sherry’S Cafe Ltd | Hospitality | 2026 |
| Sherwood Accountancy Limited | Professional & scientific | 2021 |
| Sherwood Alternative Provision Ltd | Education | 2026 |
| Sherwood Construction Services Limited | Construction | 2016 |
| Sherwood Medico-Legal Services Limited | Health & social care | 2011 |
| Sherwood Mortgages Limited | Financial services | 2007 |
| Sherwood Ranger Ltd | Hospitality | 2022 |
| Sherwood Surveyors & Property Consultants Ltd | Construction | 2010 |
| Shineexterior Ltd | Administrative & support | 2024 |
| Shiny Gateford Road Carwash Ltd | Other services | 2016 |
| Shire Farm Services Limited | Administrative & support | 2007 |
| Shireoaks Worksop Holdings Limited | Financial services | 2010 |
| Shires Property Ltd | Construction | 2025 |
| SHOP4BEARINGS Ltd | Manufacturing | 2020 |
| Shotblast Supplies Limited | Manufacturing | 1988 |
| Show Clean Ltd | Administrative & support | 2022 |
| Simon Thomas Transport Ltd | Transport & logistics | 2025 |
| Simondodsworth Ltd | Hospitality | 2019 |
| Simpatico Properties Ltd | Real estate | 2022 |
| Simplistic Renewables Ltd | Construction | 2025 |
| Simply Family Business School Limited | Education | 2021 |
| Simply Joint UK Ltd | Wholesale & retail | 2017 |
| Simply Towbars Ltd | Wholesale & retail | 2023 |
| Simpson Property Ventures Limited | Real estate | 2026 |
| Simpsons Office Solutions Limited | Other services | 2011 |
| Sinan's Gardening Ltd | Other services | 2020 |
| Sinbad Construction Ltd | Construction | 2023 |
| Singhs Medical Dinnington Limited | Wholesale & retail | 2024 |
| Singhs Medical Holdings Limited | Financial services | 2025 |
| Singhs Medical Limited | Health & social care | 2010 |
| Single Songs Limited | Information & communication | 2012 |
| Siphonic Rainwater & Drainage Services Limited | Construction | 2020 |
| Site in a Week Ltd | Information & communication | 2022 |
| Sitetown Property Management Limited | Water & waste | 1991 |
| SJC Forklift Services Ltd | Manufacturing | 2016 |
| SJR Worksop CIC | Education | 2025 |
| SJT & ADT Properties Ltd | Other services | 2016 |
| SJW the Wright Care Limited | Health & social care | 2011 |
| SK Roofing Ltd | Construction | 2025 |
| Skin Symphony Limited | Health & social care | 2025 |
| Skittle Alley Learning Limited | Education | 2024 |
| SKS Financial Limited | Financial services | 2024 |
| Sky Heating Ltd | Energy | 2018 |
| Skylook Ltd | Manufacturing | 2024 |
| Skysafaris International Ltd | Manufacturing | 2026 |
| Slaney Solutions Limited | Administrative & support | 2017 |
| SM Electrical Engineering Ltd | Construction | 2020 |
| Smart Computing Ltd | Information & communication | 2004 |
| Smart CUT S80 Ltd | Other services | 2026 |
| Smart Energy (GB) Ltd | Construction | 2011 |
| Smart GEN Solutions Ltd | Construction | 2025 |
| Smart Property Education Limited | Administrative & support | 2016 |
| Smart Property Success LLP | | 2023 |
| Smart Saddles Ltd | Manufacturing | 2006 |
| Smart Survey Solutions Ltd | Financial services | 2022 |
| Smartfix Property Limited | Construction | 2025 |
| Smartsource Investments Limited | Real estate | 2024 |
| Smartstruct Ltd | Construction | 2025 |
| Smarty Pants Ltd | Manufacturing | 2004 |
| Smgb Limited | Wholesale & retail | 1973 |
| SMH Barbers Ltd | Other services | 2025 |
| SMH Product Trading Ltd | Wholesale & retail | 2021 |
| Smokesmedia Ltd | Arts & recreation | 2022 |
| SMW Logistics Limited | Transport & logistics | 2024 |
| SMW Motors Ltd | Professional & scientific | 2025 |
| Snafu Events Limited | Arts & recreation | 2021 |
| Snazzy Groom Ltd | Other services | 2022 |
| Snep Company Ltd | Wholesale & retail | 2019 |
| Snowdrift DRY Cleaners Limited | Other services | 2015 |
| Soar Trainers Limited | Information & communication | 2019 |
| Socially Independent Community Limited | Administrative & support | 2022 |
| Sofa Emporium Limited | Wholesale & retail | 2023 |
| Soil Fertility Solutions Limited | Wholesale & retail | 2016 |