| SB Fire Safety Consultant Ltd. | Public administration | 2021 |
| Scale Hill Hotel Limited | Hospitality | 1933 |
| Scarlett Beauty Limited | Other services | 2015 |
| Schofield Family Holdings Limited | Wholesale & retail | 2024 |
| School House Court Estate Management Company Limited(The) | Real estate | 1985 |
| Scruffy Dog Media Limited | Information & communication | 2007 |
| SCT Electrical Ltd | Construction | 2021 |
| SD Quality Services Ltd | Professional & scientific | 2025 |
| SDH Brickwork Limited | Construction | 2024 |
| Seaton Academy | Education | 2010 |
| Seaton Football Club Limited | Arts & recreation | 2018 |
| SEL Construction and Maintenance Limited | Construction | 2011 |
| Select Audit Services Ltd | Extraterritorial | 2015 |
| SH Legal Ltd | Professional & scientific | 2022 |
| Shane Graham Plastering Ltd | Construction | 2016 |
| Sharpe Management Consulting Limited | Professional & scientific | 2017 |
| Shaun Quinn Limited | Construction | 2003 |
| Shaw Property Group Ltd | Real estate | 2024 |
| Signatureslabs Limited | Manufacturing | 2026 |
| Simon Mattinson Limited | Education | 2014 |
| Sing Kown House Ltd | Hospitality | 2026 |
| SJB Smart Electricals Limited | Construction | 2021 |
| SJD Cyber Security Limited | Professional & scientific | 2024 |
| SKE Developments Limited | Construction | 2022 |
| Skelton Houses Limited | Construction | 2021 |
| Skiddaw View Farm Cottages Limited | Hospitality | 2025 |
| Skills Development Ltd | Education | 2025 |
| Skinner Consultancy Ltd | Professional & scientific | 2026 |
| Skinner Property Solutions Ltd | Real estate | 2018 |
| Sksls Limited | Professional & scientific | 2025 |
| SL E-Commerce Ltd | Wholesale & retail | 2026 |
| SLK Homes and Lettings Ltd | Real estate | 2026 |
| Smallwood Properties Cumbria Ltd | Households | 2024 |
| SMASHING123 Ltd | Hospitality | 2025 |
| SMF Projects Limited | Administrative & support | 2017 |
| Smudge Properties Ltd | Real estate | 2021 |
| Sole IT Lock IT Limited | Other services | 2005 |
| Solway Blast Cleaning Limited | Construction | 2011 |
| Solway Commercials Ltd | Wholesale & retail | 2004 |
| Solway GAS & Heating Limited | Administrative & support | 2009 |
| Solway Heaters Limited | Wholesale & retail | 1990 |
| Solway Property Services Ltd | Real estate | 2025 |
| Sovereign Roofing Cumbria Ltd | Construction | 2026 |
| SP Training (West) Ltd | Education | 2023 |
| Spartin Property Ltd | Real estate | 2025 |
| Spatial Consultants Ltd | Professional & scientific | 2007 |
| Spire Project Controls Management Ltd | Professional & scientific | 2022 |
| Splash Hand Car Wash (Workington) Ltd | Administrative & support | 2025 |
| SRI Saanvi Healthcare Ltd | Wholesale & retail | 2023 |
| SSB Ventures Limited | Professional & scientific | 2002 |
| Stainburn Travel Ltd | Transport & logistics | 2024 |
| Stanbeck Property Solutions Limited | Real estate | 2024 |
| Star - Salterbeck Tenants and Residents C.I.C. | Health & social care | 2023 |
| Starling View Limited | Hospitality | 2024 |
| Start in Mate C.I.C. | Administrative & support | 2023 |
| Staveley Properties Limited | Real estate | 2020 |
| Steven Tunstall Painting & Decorating Limited | Construction | 2015 |
| Steves Paints Limited | Wholesale & retail | 1998 |
| Stobbarts Electrical Limited | Construction | 2017 |
| Stobbarts Holdings Limited | Financial services | 2013 |
| Stobbarts Limited | Construction | 1999 |
| Stonethwaite Campsite Limited | Hospitality | 2025 |
| Store 41 Ltd | Wholesale & retail | 2019 |
| STORE41 Local Ltd | Wholesale & retail | 2026 |
| Storey HR Solutions Limited | Professional & scientific | 2008 |
| Strands & Screes Holdings Limited | Hospitality | 2025 |
| Strands & Screes Hospitality Limited | Hospitality | 2025 |
| Strands Brewing & Distilling Limited | Hospitality | 2025 |
| Strength Cartel Workington Ltd | Arts & recreation | 2026 |
| Strive College CIC | Education | 2022 |
| Superchicluxe Ltd | Wholesale & retail | 2026 |
| Superdec (Cumbria) Limited | Wholesale & retail | 1995 |
| Surelock Homes Locksmith Services Ltd | Construction | 2026 |
| SVM Properties Ltd | Construction | 2004 |
| Swan Engineering Supplies Limited | Other services | 1997 |
| Swift Car Sales Lillyhall Limited | Wholesale & retail | 2017 |
| Synergy Educational and Development Consultants Limited | Information & communication | 2016 |
| Sypec Design Limited | Administrative & support | 2012 |
| T'Gether CIC | Administrative & support | 2024 |
| T-Strike Limited | Administrative & support | 2025 |
| T.A.J. Consulting Ltd | Administrative & support | 2017 |
| Taelmo Consulting Ltd | Information & communication | 2017 |
| Talaria Performance Limited | Other services | 2025 |
| Tamaisha Limited | Health & social care | 2016 |
| TAN N Glow Sunbeds Ltd | Other services | 2025 |
| Tanca Limited | Hospitality | 2025 |
| Taylor's Joinery and Plastics Limited | Construction | 2003 |
| Taylors Properties (UK) Limited | Real estate | 2001 |
| Team Graham FBA Ltd | Wholesale & retail | 2026 |
| TEC Care Consultancy Ltd | Professional & scientific | 2022 |
| Templar Safety Consultancy Ltd | Professional & scientific | 2023 |
| Terry Rourke Property Services Ltd | Real estate | 2013 |
| Test Inspect Group Limited | Professional & scientific | 2024 |
| THC Meal Preparation Limited | Hospitality | 2018 |
| THE Big Golf Company Ltd | Administrative & support | 2023 |
| THE Big Journey Company Limited | Administrative & support | 2008 |
| THE Big Safari Company Limited | Administrative & support | 2021 |
| THE Blue Cat (Cumbria) Limited | Hospitality | 2019 |
| THE Card Project UK Ltd | Information & communication | 2013 |
| THE Composite Bonding Company Ltd | Health & social care | 2015 |