| Poppy Therapy and Training Limited | Health & social care | 2017 |
| Portland Projects Ltd | Construction | 2019 |
| Pounddealz Ltd | Wholesale & retail | 2015 |
| Prepped Nutrition Ltd | Hospitality | 2025 |
| Price's Painting & Decorating Limited | Construction | 2016 |
| Priority Facilities Limited | Other services | 2018 |
| Pristine Plumb & Bath Ltd | Construction | 2026 |
| Prize Nation Ltd | Other services | 2025 |
| Prizom Ltd | Extraterritorial | 2023 |
| Proactive Business Consultants Limited | Professional & scientific | 2015 |
| Proactive Physical Health Limited | Health & social care | 2012 |
| Proactive Quality Engineering Systems Limited | Professional & scientific | 2023 |
| Project & Risk Ltd | Professional & scientific | 2018 |
| Properly Solutions Ltd | Professional & scientific | 2026 |
| Proserve(Cumbria) Limited | Extraterritorial | 2025 |
| Prospect Properties Management Limited | Households | 2018 |
| Protozoa Operations Ltd | Wholesale & retail | 2026 |
| PSJ (Bowness) Limited | Arts & recreation | 2019 |
| PSJ (Lancaster) Limited | Arts & recreation | 2017 |
| Punchbowl Cottages Limited | Real estate | 2024 |
| Punya Ltd | Education | 2023 |
| Purple Phoenix Pottery CIC | Other services | 2023 |
| PUT Together Ltd | Manufacturing | 2018 |
| PW & S Hodgson Ltd | Construction | 2014 |
| QPT Training & Nutrition Ltd | Other services | 2013 |
| Qu-Est Commercial Management Ltd | Professional & scientific | 2024 |
| Quality Coin Leisure Limited | Administrative & support | 2003 |
| Quality NS Ltd | Professional & scientific | 2026 |
| Quayside Apartments (Whitehaven) Limited | Households | 2021 |
| Queritor Limited | Professional & scientific | 2013 |
| Quick Drop Deliveries Limited | Transport & logistics | 2023 |
| R & J Industrial Supplies Ltd | Wholesale & retail | 2002 |
| R & K 2024 Limited | Transport & logistics | 2024 |
| R Cummings Consultancy Ltd | Professional & scientific | 2024 |
| R Petrie Consulting Ltd | Professional & scientific | 2022 |
| R&R Day Services Limited | Health & social care | 2022 |
| R&S Electrical Services Cumbria Ltd | Construction | 2020 |
| R.S.H Rentals Ltd | Real estate | 2025 |
| R.T.M Electrical Ltd | Professional & scientific | 2023 |
| R4U Limited | Real estate | 2024 |
| Radiance Renewable Energy Solutions Ltd | Construction | 2021 |
| Raemore Homes Limited | Construction | 2023 |
| Rapidblocs Limited | Manufacturing | 2009 |
| Rapier Storage Limited | Financial services | 2008 |
| Raymond Stevens Plant & Marine Services Limited | Manufacturing | 1996 |
| RDR Contracting Ltd | Professional & scientific | 2026 |
| Re.Works (Hair Studio) Limited | Other services | 2006 |
| React Ventures Limited | Professional & scientific | 2019 |
| Rebecca Armstrong Property Ltd | Real estate | 2025 |
| Redefine Medical Ltd | Health & social care | 2018 |
| Redghyll Ltd | Professional & scientific | 2024 |
| Reedlands Auto Centre Ltd | Wholesale & retail | 2003 |
| Regent Court Limited | Hospitality | 2016 |
| Revelation Improvements Group Ltd | Construction | 2025 |
| Revelstoke House Limited | Real estate | 2008 |
| Rewired Cumbria Ltd | Construction | 2024 |
| RG Property Cumbria Ltd | Real estate | 2026 |
| RHO Seaton Limited | Professional & scientific | 2012 |
| Richah UK Ltd | Information & communication | 2025 |
| Richard Cook (Haulage) Ltd | Transport & logistics | 2003 |
| Richard Graham Engineering Ltd | Professional & scientific | 2014 |
| Richpaddys Limited | Hospitality | 2026 |
| Rigg House Farm | Agriculture & fishing | 2013 |
| Right Property Cumbria Ltd | Real estate | 2024 |
| Riverside Grove Ltd | Hospitality | 2015 |
| RJ Building Services Cumbria Ltd | Construction | 2026 |
| RK Pharm Solutions Ltd | Health & social care | 2022 |
| RMG (Cumbria) Ltd | Construction | 2008 |
| Robert Scott Limited | Construction | 2002 |
| Robinson and Barron Ltd | Construction | 2026 |
| Robinson+Co (Cumbria) Limited | Administrative & support | 2011 |
| Robinson+Co (Gosforth) Limited | Professional & scientific | 2012 |
| Robinson+Co Financial Services Limited | Financial services | 2010 |
| Rootz Hair and Beauty Limited | Other services | 2002 |
| RPG Transport Ltd | Transport & logistics | 2025 |
| RPS Training Solutions Ltd | Administrative & support | 2019 |
| RTG Consultancy Limited | Professional & scientific | 2015 |
| Russ Devine Ltd | Professional & scientific | 2016 |
| RV Projects (Europe) Limited | Education | 2008 |
| Ryan Fisher Farm Services Limited | Extraterritorial | 2014 |
| Ryans Physique Ltd | Arts & recreation | 2019 |
| S & G Services (Cumbria) Limited | Construction | 2025 |
| S & I Inspection Limited | Professional & scientific | 2017 |
| S E Ceilings Holdings Limited | Financial services | 2022 |
| S J Mcguckin Limited | Construction | 2004 |
| S K Drainage Solutions Limited | Administrative & support | 2018 |
| S Walker Builder Limited | Construction | 2004 |
| S&P Scurr Haulage Ltd | Transport & logistics | 2020 |
| S&P Trading Limited | Hospitality | 2025 |
| S.E.B. Management Services Limited | Professional & scientific | 1999 |
| Sable Engineering and Consulting Services Limited | Professional & scientific | 2024 |
| Sacred Space Sisterhood CIC | Health & social care | 2025 |
| Sadies Takeaway Ltd | Hospitality | 2025 |
| Safe Access Scaffolding North West Ltd | Construction | 2023 |
| Salarium Limited | Extraterritorial | 2021 |
| SAM Barbers Cumbria Ltd | Other services | 2025 |
| Samurai Electrical Limited | Professional & scientific | 2012 |
| Sanigear Ltd | Hospitality | 2017 |
| Sapphire Livestock Ltd | Agriculture & fishing | 2026 |
| SAS Builders (Cumbria) Limited | Construction | 2010 |