| Stardalereach Ltd | Transport & logistics | 2022 |
| Starkey Safety Services Limited | Administrative & support | 2012 |
| Starks K9 Security Limited | Administrative & support | 2022 |
| Starlight Cleaners Ltd | Administrative & support | 2025 |
| Starlight Theatre Services Limited | Administrative & support | 2019 |
| Starlite Vine Ltd | Administrative & support | 2022 |
| Starmakr Ltd | Professional & scientific | 2026 |
| Start Site Services Ltd | Construction | 2018 |
| Start Solutions Limited | Wholesale & retail | 2003 |
| Starteq Ltd | Information & communication | 2014 |
| Stately Properties Ltd | Real estate | 2019 |
| Statham Developments Ltd | Real estate | 2026 |
| Static Systems Group Limited | Manufacturing | 1977 |
| Stavarpan Limited | Health & social care | 2023 |
| Stave-Con EOT Limited | Professional & scientific | 2022 |
| Stave-Con Holdings Limited | Financial services | 2008 |
| Stave-Con Limited | Construction | 1964 |
| Stawska M&S Limited | Construction | 2024 |
| Stay Point Ltd | Financial services | 2019 |
| Stayfolio Limited | Real estate | 2025 |
| Staysbysk Ltd | Real estate | 2026 |
| STB Foods (Wolverhampton) Limited | Wholesale & retail | 2023 |
| Steadishot UK Limited | Manufacturing | 2020 |
| Steam Engine Rivets Ltd | Manufacturing | 2023 |
| Steamvalve Ltd | Manufacturing | 2021 |
| Steedon Properties Limited | Real estate | 2025 |
| Steel Donkeys Film Ltd | Information & communication | 2026 |
| Steel Express Limited | Wholesale & retail | 2001 |
| Steel Mill Events Limited | Arts & recreation | 2017 |
| Steel Mill Films Ltd | Information & communication | 2025 |
| Steel Mill Holdings Ltd | Real estate | 2026 |
| Steel Xpress Limited | Transport & logistics | 2024 |
| Steelguard Holdings Limited | Information & communication | 2026 |
| Steelhorse Limited | Transport & logistics | 2023 |
| Steels and Lintels Ltd | Wholesale & retail | 2024 |
| Steelway Fensecure Limited | Manufacturing | 1999 |
| Steelway Group Holdings Ltd | Financial services | 2020 |
| Steelway Holdings Limited | Professional & scientific | 2010 |
| Stef Price Ltd | Real estate | 2026 |
| Stefan FOX Estate Agents Ltd | Real estate | 2024 |
| Stefan Harrison Limited | Professional & scientific | 2021 |
| Stefan Nelutu ADI Limited | Manufacturing | 2018 |
| STEFAN07 Transport Ltd | Transport & logistics | 2025 |
| Stefany Trans Limited | Transport & logistics | 2017 |
| Stellamunjere Ltd | Health & social care | 2014 |
| Stellar Goods Ltd | Wholesale & retail | 2023 |
| Stellar United Holding Ltd | Real estate | 2024 |
| Stenic Services Limited | Construction | 2005 |
| Step Compass Ltd | Information & communication | 2026 |
| Step Rail Ltd | Construction | 2023 |
| Step UP (West Midlands) Community Interest Company | Professional & scientific | 2010 |
| Step UP Support Services Limited | Professional & scientific | 2019 |
| Stephanie Taylor Limited | Financial services | 2026 |
| Stephen Makaya Ltd | Health & social care | 2025 |
| Stephenson Maintenance Limited | Professional & scientific | 1936 |
| Stepping Stones Web Ltd | Information & communication | 2017 |
| Steps for Success Limited | Professional & scientific | 2007 |
| Steps to Growth Ltd | Professional & scientific | 2020 |
| Stercus Limited | Professional & scientific | 2023 |
| Sterling Accounting & Consultancy Limited | Professional & scientific | 2015 |
| Sterling Electrical Services Limited | Construction | 2008 |
| Sterling Financial Advisers Limited | Financial services | 2001 |
| Sterling Investments Midlands Ltd | Real estate | 2019 |
| Sterling Joint Ventures Ltd | Financial services | 2025 |
| Sterling Metal Services Limited | Manufacturing | 1994 |
| Sterling Project Services Limited | Professional & scientific | 2013 |
| Sterling Textiles Limited | Wholesale & retail | 1991 |
| Sterling Window Repairs Limited | Construction | 2010 |
| Sterry Lane Ltd | Construction | 2013 |
| Steve Anthony Taylor Limited | Extraterritorial | 2022 |
| Steve Loveridge Transport Limited | Extraterritorial | 2016 |
| Steve Parkes Engineering Services Ltd | Professional & scientific | 2016 |
| Steve Perry (Transport) Limited | Transport & logistics | 2000 |
| Steve's Inflatables Ltd | Arts & recreation | 2022 |
| Stevefe Ltd | Health & social care | 2016 |
| Steventon Developments Limited | Construction | 2019 |
| Steventon Premier Homes Limited | Real estate | 2010 |
| Stevey 3D Limited | Manufacturing | 1998 |
| Stevlen Limited | Administrative & support | 2021 |
| Stewart Derbyshire Electrical Limited | Construction | 2022 |
| Stewart Henry Jones Limited | Professional & scientific | 2012 |
| Sthamosna Ltd | Transport & logistics | 2019 |
| Sthirronos Ltd | Administrative & support | 2021 |
| Stick Fingers Limited | Hospitality | 2026 |
| Stickers Wall Limited | Wholesale & retail | 2010 |
| Stiley Hardware Limited | Wholesale & retail | 2025 |
| Stirrop Property Renovations Limited | Construction | 2016 |
| Stitch and Mend Limited | Wholesale & retail | 2013 |
| STK Fire and Risk Management Limited | Health & social care | 2009 |
| Stock Stream Wholesale Ltd | Wholesale & retail | 2026 |
| Stockfoundation.Org | Extraterritorial | 2011 |
| Stocknroll Limited | Professional & scientific | 2010 |
| Stockton Court Right to Manage Company Limited | Professional & scientific | 2008 |
| Stockwell Facilities Management Limited | Households | 2024 |
| Stockwell Homes (Wolverhampton) Limited | Real estate | 2016 |
| Stockwell Management Company Limited | Real estate | 2007 |
| Stocxbuy Limited | Wholesale & retail | 2026 |
| Stoic Stack Coffee Ltd | Manufacturing | 2026 |
| Stoica F Ltd | Construction | 2025 |
| Stoke Cross Farm Finstall Ltd | Construction | 2024 |