| E-Z Rect Limited | Wholesale & retail | 1993 |
| E-Z-Rect Holdings Limited | Financial services | 2003 |
| E2E-ASSURE Limited | Information & communication | 2013 |
| E2E-CYBER Limited | Information & communication | 2013 |
| E2E-ENGAGE Limited | Information & communication | 2019 |
| E2E-GROUP Limited | Professional & scientific | 2020 |
| E2GO Packaging Ltd | Wholesale & retail | 2026 |
| EAC Network Solutions Limited | Information & communication | 2005 |
| Eadles Developments Limited | Real estate | 2021 |
| Eadles Holdings Limited | Professional & scientific | 2022 |
| Eadles Investments Limited | Real estate | 2022 |
| Eadles Limited | Wholesale & retail | 2016 |
| Eager Lobster Ltd | Information & communication | 2026 |
| Earlyedunest Ltd | Education | 2024 |
| Earth Day Festival Limited | Administrative & support | 2021 |
| Earthline Aggregates Ltd | Mining & quarrying | 2015 |
| Earthline Recycling Ltd | Mining & quarrying | 2015 |
| Earthwise Girls Limited | Wholesale & retail | 2018 |
| Easington Terrace LLP | | 2020 |
| East-Link Recruitment Services Limited | Administrative & support | 2004 |
| Easy Crem Forms Ltd | Information & communication | 2026 |
| Easyreach Accounts Ltd | Wholesale & retail | 2023 |
| Easyreach Underwear UK Ltd | Wholesale & retail | 2022 |
| Eaton Court Residents Association (Oxford) Limited | Real estate | 1978 |
| Eaton Gate (Kidlington) Management Company Limited | Households | 2009 |
| Ebico Energy Ltd | Energy | 2020 |
| Ebico Limited | Financial services | 1998 |
| Ebico Trading Limited | Energy | 2015 |
| EBV Ltd | Real estate | 2023 |
| Eclipse Barn Racing LLP | | 2024 |
| Ecocleanpartners Ltd | Administrative & support | 2025 |
| Ecohouse Initiative Ltd | Professional & scientific | 2013 |
| ED Isard Ltd | Administrative & support | 2022 |
| ED Jackson Property Limited | Real estate | 2020 |
| Edam House Ltd | Professional & scientific | 2026 |
| EDE Developments (Oxford) Limited | Construction | 1959 |
| EDE Holdings Limited | Construction | 1964 |
| EDE Homes Limited | Real estate | 2006 |
| Edelweiss HR Ltd | Administrative & support | 2018 |
| Eden Health Consultancy Limited | Health & social care | 2014 |
| Edenzgrain Exports UK Ltd | Wholesale & retail | 2022 |
| Edespare Limited | Construction | 2011 |
| Edfolio Ltd | Education | 2020 |
| Edgars Holdings Limited | Financial services | 2026 |
| Edgars Limited | Professional & scientific | 2001 |
| EDGE1874 Ltd | Professional & scientific | 2025 |
| Edginton Contractors Limited | Construction | 2015 |
| Edminson Limited | Construction | 2014 |
| Edmunds Construction Limited | Construction | 2006 |
| Education for Everyone Ltd | Other services | 2016 |
| Educave Ltd | Education | 2025 |
| Eduwise Limited | Education | 2005 |
| Edwards Holdings Limited | Manufacturing | 1976 |
| Edwardson Lettings Limited | Real estate | 2013 |
| Efficient Project Management Services Limited | Professional & scientific | 2015 |
| EFS Homes Limited | Real estate | 2018 |
| Ehoom Limited | Financial services | 2023 |
| EJ Junior Investments Limited | Real estate | 2021 |
| EK Clinic Witney Limited | Health & social care | 2025 |
| EL108 Limited | Real estate | 2023 |
| Electric Billy Limited | Construction | 2006 |
| Electric Engineering Co. Ltd. | Manufacturing | 1977 |
| Electro Magnetic Properties Ltd | Real estate | 2019 |
| Electrokinematic Ltd | Manufacturing | 2021 |
| Electromotive Components Limited | Wholesale & retail | 2001 |
| ELF Training Limited | Arts & recreation | 2026 |
| Elinor Sophia Limited | Manufacturing | 2018 |
| Elisten UK Limited | Real estate | 2018 |
| Elite Soccer Stars Ltd | Education | 2025 |
| Elite-Clean Oxfordshire Limited | Other services | 2014 |
| Elivia Capital Management Ltd | Professional & scientific | 2011 |
| Elizabeth Anne Designs Limited | Professional & scientific | 1995 |
| Elizabeth Dawson Associates Ltd | Professional & scientific | 2023 |
| Elliott Fitness and Rehabilitation Ltd | Arts & recreation | 2024 |
| Ellite Food Limited | Hospitality | 2013 |
| ELM E-Commerce Ltd | Wholesale & retail | 2021 |
| Elmleaze Farm Ltd | Financial services | 2021 |
| Elsharkawy Islamic Culture Centre CIC | Administrative & support | 2023 |
| Elysian Affairs by Stella Ltd | Other services | 2025 |
| EMANUEL93 Limited | Health & social care | 2019 |
| Embarr Limited | Financial services | 2014 |
| EMC Joinery Limited | Manufacturing | 2020 |
| EMC Medical Services Limited | Health & social care | 2009 |
| Emergent Design Ltd | Information & communication | 2011 |
| Emex Technologies Limited | Administrative & support | 2014 |
| Emfs Group Holdings Ltd | Financial services | 2022 |
| Emfs Group Limited | Financial services | 2020 |
| Emixa Industry Solutions Limited | Wholesale & retail | 2017 |
| Emma Lynch Limited | Professional & scientific | 2010 |
| Emmabros Limited | Other services | 2024 |
| Emotion Broadcast Systems Limited | Information & communication | 2009 |
| Empire Contractors (Oxford) Ltd | Construction | 2023 |
| Empire Holdings (Oxford) Ltd | Financial services | 2024 |
| Empire Maintenance (Oxford) Ltd | Construction | 2023 |
| Empire Properties (Oxford) Ltd | Real estate | 2025 |
| Empire Roofing Services (Oxford) Ltd | Construction | 2020 |
| Emporiam Removals Ltd | Transport & logistics | 2024 |
| Empowered Coaching and Consultancy Limited | Health & social care | 2026 |
| EMS Pro Limited | Information & communication | 2026 |
| Emstones Limited | Hospitality | 2014 |