| Refuel-Uk Ltd | Manufacturing | 2016 |
| Refurb Wirral Ltd | Construction | 2024 |
| Regal Gentleman Ltd | Wholesale & retail | 2014 |
| Regal Wholesale Limited | Wholesale & retail | 1989 |
| Regen City Ltd | Professional & scientific | 2025 |
| Regent D. C. Ltd | Real estate | 2022 |
| Regent Holdings Ltd | Real estate | 2015 |
| Regent Power Consulting Ltd | Professional & scientific | 2024 |
| Regional Medical Services Ltd | Health & social care | 2015 |
| Registered Marine Surveying (RMS) Ltd | Transport & logistics | 2022 |
| Rehability Therapies Limited | Health & social care | 2025 |
| Rehirst Ltd | Construction | 2025 |
| Rehoboth UK Incorporated Ltd | Health & social care | 2008 |
| Reignite LRP Ltd | Arts & recreation | 2026 |
| Reimagined Futures International Ltd | Professional & scientific | 2023 |
| Relentless Sports Ltd | Arts & recreation | 2022 |
| Reliance Marine (Wirral) Ltd | Wholesale & retail | 2005 |
| Reliant Roofing Services Limited | | 1983 |
| Relyk Properties Ltd | Real estate | 2020 |
| Remain Independent Ltd | Real estate | 2016 |
| Remote Environmental Monitoring Ltd | Other services | 2022 |
| Remote Limited | Information & communication | 2004 |
| Remote Sounds Limited | Information & communication | 2004 |
| Rendclad Ltd | Construction | 2025 |
| Renewed Hope Ltd | Health & social care | 2026 |
| Renso Bars UK Limited | Wholesale & retail | 2024 |
| Replace My Vehicle Ltd | Administrative & support | 2021 |
| Repleay Limited | Arts & recreation | 2011 |
| Requisite Agency Ltd | Professional & scientific | 2024 |
| Resa Estates Limited | Real estate | 2025 |
| Residences Upholland Limited | Real estate | 2024 |
| Resillios Ltd | Wholesale & retail | 2020 |
| Resolution Safety Ltd | Professional & scientific | 2018 |
| Resus Tree Ltd | Health & social care | 2014 |
| RET Events Ltd | Administrative & support | 2026 |
| Rethink NOW CIC | Other services | 2019 |
| Retro Peloton Ltd | Wholesale & retail | 2025 |
| Retrofit Building Services Limited | Professional & scientific | 2023 |
| Return to Endor Limited | Administrative & support | 2017 |
| Reuben Enterprises Ltd | Professional & scientific | 2025 |
| Revitalaser Franchise Ltd | Extraterritorial | 2011 |
| Revitalaser Limited | Other services | 2011 |
| Revive 369 Ltd | Other services | 2025 |
| Revive Social Care Limited | Real estate | 2017 |
| Revolution Hair Systems Ltd | Other services | 2020 |
| Revolve Capital Ltd | Construction | 2021 |
| Revradar Ltd | Information & communication | 2026 |
| Rewirekit.Com Limited | Wholesale & retail | 2024 |
| Reynolds Craft ALE Supplies Limited | Wholesale & retail | 2022 |
| Reynolds Properties Limited | Real estate | 1997 |
| RF Radiology Ltd | Health & social care | 2023 |
| Rfab Services Ltd | Administrative & support | 2020 |
| RG Events & Floral Ltd | Wholesale & retail | 2026 |
| RGC Property Consultants Limited | Real estate | 2019 |
| RGK Property Maintenance Ltd | Real estate | 2016 |
| Rhinotowbarsandtrailers Limited | Wholesale & retail | 2016 |
| Rhys Crook Ltd. | Financial services | 2021 |
| Riadago Limited | Health & social care | 2022 |
| Rianoia Ltd | Real estate | 2022 |
| Riarosa Ltd | Real estate | 2022 |
| Ribon Upton Ltd | Real estate | 2021 |
| Rice Consulting Services Ltd | Professional & scientific | 2026 |
| Rich Build Construction & Maintenance Ltd | Construction | 2017 |
| Rich Master Developments Limited | Other services | 2021 |
| Richard Dean Hughes Ltd | Arts & recreation | 2024 |
| Richard Ellis Plumbing & Heating Limited | Construction | 2009 |
| Richard Harris Cars Limited | Wholesale & retail | 2021 |
| Richard Harris Property Limited | Real estate | 2026 |
| Richard O'Brien Joinery and Building Ltd | Construction | 2012 |
| Richard P. Walsh & Company Limited | Wholesale & retail | 1996 |
| Richard Rogers Excavation Limited | Construction | 2017 |
| Richard Warwick Developments Limited | Construction | 1997 |
| Richie's Carpets Ltd | Wholesale & retail | 2011 |
| Richmond House Management Company (Aigburth) Limited | Households | 2008 |
| Richmond Mews Boughton Limited | Households | 1996 |
| Richnotes Limited | Professional & scientific | 2023 |
| Ridgewood Legal Limited | Real estate | 2020 |
| RIG IT Tech IT Rock IT Limited | Manufacturing | 2015 |
| Rightclick (UK) Limited | Information & communication | 2011 |
| Riiya Ltd | Information & communication | 2024 |
| Riley's PA Ltd | Administrative & support | 2023 |
| RIN Properties Limited | Real estate | 2020 |
| Ripperholics Ltd | Wholesale & retail | 2025 |
| Ripple Marine Ltd | Professional & scientific | 2010 |
| Riptide Innovates Ltd | Professional & scientific | 2024 |
| Rise Health Wirral Ltd | Arts & recreation | 2025 |
| Rise Wirral CIC | Education | 2022 |
| Rise Women Community Interest Company | Other services | 2026 |
| Riskapplication Limited | Information & communication | 2026 |
| Riverbed Estates Ltd | Real estate | 2009 |
| Rivercross Media Ltd | Professional & scientific | 2021 |
| Riverfree Limited | Professional & scientific | 1990 |
| Rivers Operations Limited | Transport & logistics | 2020 |
| Riversdale Court (West Kirby) Owners Company Limited | Households | 2011 |
| Riverside Premier Ltd | Wholesale & retail | 2022 |
| RJ Bennett Consulting Limited | Wholesale & retail | 2019 |
| RJE Solutions Ltd | Transport & logistics | 2006 |
| RJH Construction Services Ltd | Professional & scientific | 2022 |
| RJH Project Services Ltd | Construction | 2022 |
| RJS Group Northwest Limited | Construction | 2023 |