| R.S.L. Estates Limited | Real estate | 1998 |
| R.W.Jones (Heswall) Limited | Manufacturing | 1987 |
| R4S Food Innovations Ltd | Hospitality | 2024 |
| RA Property Lets Ltd | Real estate | 2021 |
| RA Property Projects Ltd | Construction | 2021 |
| Raas Consultants Ltd | Information & communication | 2023 |
| Raby Laser Retreat Limited | Other services | 2021 |
| Raby Ryelands Limited | Professional & scientific | 2026 |
| Race Wirral Ltd | Arts & recreation | 2025 |
| Rach's Heating and Plumbing Services Limited | Construction | 2026 |
| Rachael Bampton-Aiken Limited | Professional & scientific | 2008 |
| Rachel Keenan & Co. Ltd | Professional & scientific | 2008 |
| Rachel Lewis Design Ltd | Professional & scientific | 2019 |
| Rachel Owen Consulting Limited | Information & communication | 2013 |
| Radic Creative Ltd | Information & communication | 2024 |
| Radons Project Management Limited | Administrative & support | 2015 |
| Radread Limited | Health & social care | 2019 |
| Rafadistributions Ltd | Wholesale & retail | 2024 |
| Rafferty Lettings Limited | Real estate | 2015 |
| Raging Beasts Ltd | Manufacturing | 2023 |
| Rail Bentley Ltd | Administrative & support | 2018 |
| Rain OR Shine Ltd | Other services | 2024 |
| Rainbow Trading Limited | Wholesale & retail | 2022 |
| Raisins Star Limited | Wholesale & retail | 2024 |
| Rajan Specialities Limited | Health & social care | 2018 |
| Rajneesh Misra Neuro Consultants Private Ltd | Health & social care | 2024 |
| Rake Booze Limited | Wholesale & retail | 2013 |
| RAM Plumbing & Heating Merchants Limited | Construction | 2020 |
| Ramleh Residents Association Limited | Households | 2006 |
| Ramotswa Limited | Information & communication | 2014 |
| Rana Restaurant Wirral Ltd | Hospitality | 2025 |
| Ranford Property Ltd | Real estate | 2026 |
| Rani Spices Wirral Ltd | Hospitality | 2025 |
| Ranjit Sahota Limited | Professional & scientific | 2016 |
| Rapid Hydraulic Services Limited | Manufacturing | 2007 |
| Rapidsteel Panels & Fixings Limited | Administrative & support | 2017 |
| Rapsock Limited | Real estate | 1958 |
| Rare Bear UK Ltd | Manufacturing | 2024 |
| Raskino Consulting Limited | Professional & scientific | 2007 |
| Raspberry Ranch Ltd | Real estate | 2021 |
| Raspberry Trade Ltd | Wholesale & retail | 2018 |
| Ratoll Services Limited | Professional & scientific | 2015 |
| Raventa Ltd | Professional & scientific | 2014 |
| Raventa Trading Limited | Professional & scientific | 1986 |
| RAW Music Ltd | Information & communication | 2013 |
| RAW Photography Limited | Professional & scientific | 2010 |
| RAW Solutions (NW) Limited | Professional & scientific | 2020 |
| Rayal Taste CH46 Ltd | Hospitality | 2026 |
| RB Endeavours Limited | Health & social care | 2024 |
| Rboulton Commercial Ltd | Real estate | 2021 |
| Rboulton Property Ltd | Real estate | 2020 |
| RBS Healthworks Ltd | Health & social care | 2026 |
| RC Estates Ltd | Real estate | 2022 |
| Rcfr Limited | Administrative & support | 2017 |
| RDF Electrical & Security Ltd | Manufacturing | 2025 |
| RDS Sumathi First Health Ltd | Health & social care | 2024 |
| Re:Nutrition Ltd | Health & social care | 2020 |
| React Site Services Limited | Administrative & support | 2015 |
| Read NOW Write NOW Limited | Information & communication | 2015 |
| Readbax Properties Ltd | Real estate | 2024 |
| Readymade Arcade Ltd | Wholesale & retail | 2021 |
| Readysetgo Success and Wellbeing CIC | Health & social care | 2025 |
| Real Scenes Education Ltd | Education | 2026 |
| Real Space Ltd | Manufacturing | 2016 |
| Realsoul Cotton Ltd | Wholesale & retail | 2023 |
| Rebecca Barclay Interiors Ltd | Professional & scientific | 2024 |
| Rebecca Gouldson Ltd | Arts & recreation | 2012 |
| Rebecca Louise Hairdressing Ltd | Other services | 2018 |
| Reclaimed Timber Liverpool Limited | Wholesale & retail | 2018 |
| Recommend Recruitment Services Limited | Administrative & support | 2019 |
| Recon Asset Management Co. Ltd | Professional & scientific | 2021 |
| Recover Hyperbarics Ltd | Wholesale & retail | 2023 |
| Recovero Ltd | Arts & recreation | 2025 |
| Recoverylux Limited | Health & social care | 2023 |
| Recreational Wardrobe CIC | Education | 2024 |
| Recycling Futures Ltd | Wholesale & retail | 2024 |
| Red 8 Ltd | Extraterritorial | 2007 |
| Red Apple Education Ltd | Administrative & support | 2014 |
| Red Apple Recruitment Limited | Administrative & support | 2018 |
| Red Creative Solutions Ltd | Information & communication | 2018 |
| Red Rocks Consulting Limited | Administrative & support | 2006 |
| Red Rocks Engineering Ltd | Professional & scientific | 2018 |
| Red Rocks Flat Management Company Limited | Households | 1975 |
| Red Rocks Marine Ltd | Professional & scientific | 2019 |
| Red Square Grocers Ltd | Wholesale & retail | 2025 |
| Redapple 7 Limited | Professional & scientific | 2019 |
| Redcliff Developments Limited | Construction | 2016 |
| Redcote Court (West Kirby) Limited | Professional & scientific | 2013 |
| Redcote Court Limited | Professional & scientific | 1990 |
| Redfox Woodcraft Limited | Manufacturing | 2025 |
| Redge.Cover Ltd | Professional & scientific | 2025 |
| Redhaven Consulting Limited | Administrative & support | 2026 |
| Redhead Events Limited | Extraterritorial | 2016 |
| Redmen Lettings Limited | Real estate | 2020 |
| Redrum Cartel Limited | Arts & recreation | 2023 |
| Redstones Technologies Limited | Professional & scientific | 2014 |
| Reece Investment Properties Limited | Real estate | 2005 |
| Reed Lane Developments Ltd | Real estate | 2017 |
| Reflective and Relational Practice in Education CIC | Education | 2026 |
| Refocus ND Services Limited | Health & social care | 2025 |