| Safety Shield AI Ltd | Information & communication | 2021 |
| Safety Shield Global Limited | Information & communication | 2018 |
| Safety Shield Group Limited | Information & communication | 2021 |
| Safety Shield Rail Limited | Information & communication | 2023 |
| Safety Shield VUE Ltd | Information & communication | 2020 |
| Safshen Prospects Ltd | Other services | 2017 |
| Saint Flooring Limited | Construction | 2008 |
| Salem Heritage Co Ltd | Manufacturing | 2026 |
| Sales Androids Ltd | Professional & scientific | 2025 |
| Salt House Veterinary Centre Ltd | Professional & scientific | 2017 |
| Salt Union Limited | Professional & scientific | 2000 |
| Salterswall Technical Solutions Limited | Information & communication | 2025 |
| Samis Barber Ltd | Other services | 2018 |
| Sandiway Capital Partners Ltd | Financial services | 2025 |
| Sandstone Ridge Estates Limited | Hospitality | 2022 |
| Sandyacre Services Ltd | Construction | 2024 |
| Sara Doors Ltd | Manufacturing | 2018 |
| SB Electrical Services (Cheshire) Limited | Construction | 2023 |
| SC Training Ltd | Public administration | 2020 |
| Scholar Rise Management Company (Winsford) Limited | Real estate | 2005 |
| Scully Gauging and Control Systems Ltd. | Professional & scientific | 1993 |
| Scully U.K. Limited | Manufacturing | 1985 |
| SDW Electrical Cheshire Ltd | Construction | 2025 |
| Secondtek Limited | Wholesale & retail | 2001 |
| Security Performance Architecture Limited | Information & communication | 2015 |
| SEE Impact Ltd | Extraterritorial | 2024 |
| Select and Save Winsford Ltd | Wholesale & retail | 2025 |
| Select Window Systems Limited | Construction | 2003 |
| Seprascience Limited | Manufacturing | 2009 |
| Serenity Homes North West Limited | Real estate | 2026 |
| Sergiu Birladeanu Ltd | Transport & logistics | 2020 |
| Sesu Transport Ltd | Transport & logistics | 2025 |
| Severance Ltd | Wholesale & retail | 2025 |
| Sevyn Drinks Limited | Wholesale & retail | 2024 |
| Seymour Properties (Winsford) Limited | Real estate | 1963 |
| SG Cash and Carry Ltd | Construction | 2021 |
| Shadow Foam Limited | Manufacturing | 2012 |
| Shane Hanwell Limited | Construction | 2002 |
| Shent-Events Marquee Hire Ltd | Other services | 2016 |
| Shine Car Wash Pro Ltd | Administrative & support | 2024 |
| Shuse (T/A Cheeky Little Soles) Ltd | Wholesale & retail | 2018 |
| SIG Properties Ltd | Real estate | 2018 |
| Silver HOG Solutions Ltd | Construction | 2015 |
| Simply Signs (Cheshire) Limited | Administrative & support | 2002 |
| Sisu Consulting Ltd | Information & communication | 2023 |
| SIZE41 Digital Limited | Professional & scientific | 2017 |
| SJB Instrumentation Ltd | Professional & scientific | 2018 |
| SJP Develops Ltd | Information & communication | 2023 |
| SJW Property Holdings Ltd | Real estate | 2017 |
| SKN Traders Ltd | Wholesale & retail | 2020 |
| Skyline Scaffolding - Cheshire Ltd | Construction | 2025 |
| Smart Climate AC Ltd | Energy | 2019 |
| Smart Thing Solutions Limited | Financial services | 2016 |
| Smee Holdings Limited | Real estate | 1974 |
| Snagapro Ltd | Construction | 2025 |
| Snelsons (Holdings) Limited | Financial services | 2024 |
| Snelsons Limited | Manufacturing | 2006 |
| Soluble Technology Limited | Professional & scientific | 2005 |
| Solutech Limited | Manufacturing | 1994 |
| Somerford Foods Limited | Hospitality | 2015 |
| Southview Equestrian Centre Limited | Administrative & support | 1997 |
| SPAC3 Fitness Ltd | Arts & recreation | 2024 |
| Spero (Sandbach) Ltd | Transport & logistics | 2012 |
| Sprint and Spoke Ltd | Wholesale & retail | 2025 |
| Sproutt Ltd | Information & communication | 2026 |
| Squidzillaink Limited | Wholesale & retail | 2021 |
| Squire Surveyors Ltd | Professional & scientific | 2023 |
| Squirrel Medical Limited | Wholesale & retail | 2004 |
| SRL Traffic Systems Limited | Manufacturing | 1997 |
| ST Chad's Community Enterprises | Education | 2005 |
| ST Luke's (Cheshire) Hospice | Health & social care | 1984 |
| ST Luke's Hospice Promotions Limited | Arts & recreation | 1993 |
| ST Luke's Hospice Trading Limited | Wholesale & retail | 1995 |
| ST Rentals Limited | Real estate | 2025 |
| Stag Fencing Limited | Administrative & support | 2020 |
| Steadfast Engineering Supplies Limited | Wholesale & retail | 2003 |
| Steele House Health & Social Care Consultancy Ltd | Extraterritorial | 2024 |
| Steve Dunning Ltd | Construction | 2013 |
| Stickerbods Limited | Administrative & support | 2008 |
| STM Power Transmission Ltd | Manufacturing | 1990 |
| Stratton Search Ltd | Administrative & support | 2020 |
| Strive Bridge Ltd | Information & communication | 2024 |
| Strong Culture LLP | | 2025 |
| SUG Enterprises Ltd | Wholesale & retail | 2026 |
| Sunblaze Tours Ltd | Administrative & support | 2018 |
| Sunflower Childcare Services Ltd | Administrative & support | 2025 |
| Sunstar Shining Limited | Wholesale & retail | 2016 |
| Sunstone HR Limited | Professional & scientific | 2016 |
| Suntech Consultants Ltd | Information & communication | 2021 |
| Sustainable Building Services (2013) Limited | Other services | 2013 |
| SW Accounting Services Limited | Professional & scientific | 2021 |
| Swift Electrical Services (Cheshire) Limited | Construction | 2012 |
| Symms-Williams Geological Limited | Professional & scientific | 2020 |
| T66 Holdings Ltd | Financial services | 2023 |
| T66 Ltd | Information & communication | 2020 |
| T66 Property Rentals Ltd | Real estate | 2023 |
| Tactile Tiles Ltd | Manufacturing | 2025 |
| Talserve Consulting Ltd | Administrative & support | 2024 |
| Talserve Holdings Ltd | Financial services | 2024 |
| Talserve Investments Ltd | Real estate | 2024 |