| Physiotherapy Clinics (Cheshire) Ltd | Health & social care | 2014 |
| Pickering Property Services Limited | Construction | 2004 |
| Pinpoint Property Estates Ltd | Real estate | 2023 |
| PJR Residential Consulting (CYP) Limited | Public administration | 2026 |
| Pluto Constructions Ltd | Construction | 2025 |
| Polar Palace Limited | Arts & recreation | 2006 |
| Pound Stretch Limited | Wholesale & retail | 2023 |
| Power Source Engine Parts Limited | Wholesale & retail | 2010 |
| Power-All Europe Limited | Manufacturing | 2006 |
| Premier CRU Investments Limited | Financial services | 2025 |
| Premier Holdings Northwich Limited | Real estate | 2016 |
| Premier Image Services Limited | Manufacturing | 2015 |
| Premier Insurance Centre Limited | Financial services | 1992 |
| Prime Barber Winsford Ltd | Other services | 2023 |
| Prime Fastfood Ltd | Hospitality | 2025 |
| Print Your Memory Limited | Professional & scientific | 2020 |
| Prismatape U.K. Limited | Wholesale & retail | 1991 |
| Privy Ltd | Manufacturing | 2024 |
| PROACTIV8 Ltd | Other services | 2023 |
| Professional PA Ltd | Health & social care | 2022 |
| Project Empire (UK) Limited | Construction | 2009 |
| Prolive Technical Production Services Limited | Administrative & support | 2015 |
| Promechanical Ltd | Construction | 2025 |
| Property Wise Group Ltd | Administrative & support | 2023 |
| Propertymatch Sourcing Limited | Real estate | 2024 |
| PRP DEV Ltd | Real estate | 2025 |
| PRP Renovations Limited | Real estate | 2024 |
| PRS Engineering Ltd | Manufacturing | 2017 |
| Psalms Children's Home Ltd | Education | 2025 |
| Pseudocode Ltd | Information & communication | 2023 |
| Purple Property Inc Ltd | Construction | 2026 |
| PY Project Services Limited | Administrative & support | 2008 |
| Quick Bites NW Ltd | Hospitality | 2025 |
| Quinton Travel Ltd | Administrative & support | 2017 |
| Quotrium Limited | Professional & scientific | 2014 |
| Qwest Services Limited | Professional & scientific | 2015 |
| R & G Roofing Services Ltd | Construction | 2026 |
| R & M Finney Limited | Construction | 2015 |
| R James Construction Ltd | Construction | 2020 |
| R P Landscapes Ltd | Other services | 2016 |
| R&T Roofing Services Ltd | Construction | 2025 |
| R. Milner & Sons Limited | Hospitality | 1960 |
| RA Commercial Property Maintenance Ltd | Water & waste | 2015 |
| Rabble Limited | Financial services | 2000 |
| Radical Therapist Network CIC | Education | 2022 |
| Rail Group Solutions Ltd | Administrative & support | 2019 |
| Rain OR Shine Records Limited | Information & communication | 2016 |
| Rainbow Healthcare Private Limited | Health & social care | 2016 |
| Rainbow Raves Ltd | Wholesale & retail | 2023 |
| Rainy Grinch Ltd | Information & communication | 2026 |
| Raleigh Adhesive Coatings Limited | Manufacturing | 1988 |
| Rama Inc Limited | Health & social care | 2014 |
| Rangos Holdings Limited | Hospitality | 2017 |
| Rbbcservices Limited | Professional & scientific | 2024 |
| RCL Care Services Limited | Health & social care | 2023 |
| RCT Industries Ltd | Professional & scientific | 2025 |
| Reflec Evolution Limited | Manufacturing | 1997 |
| Reflec Media Ltd | Manufacturing | 1993 |
| Reflec PLC | Manufacturing | 1995 |
| Reign Season Ltd | Wholesale & retail | 2019 |
| Renovex Ltd | Construction | 2025 |
| Renray Healthcare Group Ltd | Manufacturing | 2020 |
| Renray Healthcare Limited | Manufacturing | 2007 |
| Renray Holdings Limited | Professional & scientific | 2007 |
| REPORTS4 Ltd | Information & communication | 2015 |
| Resmar Limited | Wholesale & retail | 1999 |
| Resource Cupboard Ltd | Information & communication | 2025 |
| Retailscout Ltd | Information & communication | 2026 |
| Reventador Ltd | Administrative & support | 2008 |
| RG Fire Limited | Public administration | 2022 |
| Richard Williams Upholstery Ltd | Other services | 2016 |
| Rilshaw Development Ltd | Information & communication | 2026 |
| Rilshaw Electrical Services Ltd | Construction | 2022 |
| River of Life Church Winsford | Other services | 2005 |
| RJ Property Lettings Ltd | Manufacturing | 1990 |
| RJ Tuning Ltd | Wholesale & retail | 2016 |
| RM MOT Centre Ltd | Wholesale & retail | 2024 |
| Rmdg Limited | Administrative & support | 1998 |
| Road Four Storage Limited | Real estate | 2026 |
| Robin Wood & Sons Limited | Administrative & support | 2018 |
| Rooms Group Holdings Limited | Financial services | 2022 |
| Rooms Group Limited | Construction | 2014 |
| Rooms Group Property Limited | Real estate | 2024 |
| Rosalyn Bingham Limited | Hospitality | 2019 |
| Rose Consultancies Limited | Health & social care | 2022 |
| Rowe Surfacing and Fencing Ltd | Administrative & support | 2024 |
| Royel Kebab and Pizza Ltd | Hospitality | 2016 |
| RSH Property Holdings Ltd | Real estate | 2017 |
| Rupert Maxwell Grounds Maintenance Ltd | Administrative & support | 2015 |
| S & D Surveyors Ltd | Professional & scientific | 2020 |
| S & D T Limited | Construction | 2013 |
| S & J Lomas Butchers Ltd | Wholesale & retail | 2018 |
| S a Electrical (Manchester) Limited | Construction | 2012 |
| S Cooper Group Limited | Financial services | 2016 |
| S Cooper Properties Limited | Real estate | 2010 |
| S&A Administrative Services Limited | Administrative & support | 2024 |
| S.M. Book-Keeping Services Limited | Professional & scientific | 2002 |
| S.P. Diesels Limited | Manufacturing | 2002 |
| Safe Solutions (SAFE4) Limited | Manufacturing | 2004 |
| Safer Cheshire Limited | Education | 2015 |