| RM Endodontics Limited | Health & social care | 2016 |
| RMB Pro Direct Ltd | Professional & scientific | 2025 |
| RMS (EOT) Trust Company Limited | Financial services | 2025 |
| RMS Marketing Advertising & Public Relations Limited | Administrative & support | 1991 |
| Rmtp Properties Limited | Households | 2025 |
| RN Medical Ltd | Health & social care | 2019 |
| RN Vascular Services Ltd | Information & communication | 2022 |
| RNR Medical Services Limited | Health & social care | 2019 |
| ROB Rach Wingman Ltd | Information & communication | 2025 |
| ROB Winterton Plastic Surgery Limited | Health & social care | 2016 |
| Robert Norgrove Commissioning Limited | Professional & scientific | 2024 |
| Robert S.Maynard Limited | Wholesale & retail | 1961 |
| Robin SIL Limited | Health & social care | 2021 |
| Robinson Rose Wealth Management Ltd | Professional & scientific | 2022 |
| Roboreception Limited | Information & communication | 2022 |
| Robotic Surgery Limited | Health & social care | 2020 |
| Robson Whiteley Ltd | Administrative & support | 2015 |
| Robswall Consulting Ltd | Professional & scientific | 2013 |
| Rock Advisory Limited | Professional & scientific | 2016 |
| Rocket Money Limited | Financial services | 2024 |
| Rockhopper Holidays Ltd | Administrative & support | 2025 |
| Roma XP Group Ltd | Hospitality | 2025 |
| Romany of the BBC C.I.C. | Other services | 2023 |
| Romilla 2 Limited | Real estate | 2022 |
| Romilla 2 Rental Company Limited | Real estate | 2025 |
| Romilla Limited | Real estate | 2017 |
| Romilla Rental Company Limited | Real estate | 2025 |
| Rooftops Estate Agents Limited | Real estate | 2017 |
| Roonoo Health Ltd | Professional & scientific | 2025 |
| Rooster Retail Limited | Wholesale & retail | 2013 |
| Root and Flower Ltd | Wholesale & retail | 2012 |
| Root Creations Ltd | Wholesale & retail | 2020 |
| Ropafadzo Limited | Health & social care | 2026 |
| Roque Medical Limited | Health & social care | 2022 |
| Rosalia Medical Ltd | Health & social care | 2021 |
| Rosavi Limited | Health & social care | 2023 |
| Rosebud Media Limited | Professional & scientific | 2021 |
| Rosemead Medical Services Limited | Health & social care | 2015 |
| Rosewood House Pets Limited | Agriculture & fishing | 2014 |
| Rosh Aesthetics Limited | Health & social care | 2020 |
| Rosie Designer Ltd | Other services | 2019 |
| Rossini Motor Sports Limited | Wholesale & retail | 2015 |
| Rosthern Investments Limited | Real estate | 2021 |
| ROTUNDA57 Expo Ltd | Transport & logistics | 2019 |
| Roupell Advisory Limited | Professional & scientific | 2017 |
| Rowan Court (Hazel Grove) Limited | Households | 1988 |
| Rowlands Eyes Ltd | Health & social care | 2019 |
| Rowtest 200 Ltd | Manufacturing | 2025 |
| Roya Jane Marketing Limited | Professional & scientific | 2021 |
| Royce Properties Ltd | Real estate | 2025 |
| Royks Ltd | Health & social care | 2022 |
| RPB Consultants Limited | Professional & scientific | 2025 |
| Rrtd Limited | Health & social care | 2024 |
| RS Medical Consultancy Limited | Health & social care | 2019 |
| RSK Aesthetics Limited | Health & social care | 2026 |
| RSM Reports Limited | Health & social care | 2013 |
| RSV Diagnostics Ltd | Real estate | 2013 |
| RSW Advisory Services LLP | | 2013 |
| Ruby Properties & Investment Ltd | Real estate | 2026 |
| Rudnick Health Limited | Health & social care | 2024 |
| Rudwan Limited | Health & social care | 2023 |
| RUM88 Limited | Health & social care | 2020 |
| Run Creative Ltd | Professional & scientific | 2010 |
| Run North West Limited | Wholesale & retail | 2016 |
| Runway Car Rentals Ltd | Information & communication | 2024 |
| Rush UK Entertainment Limited | Wholesale & retail | 2015 |
| Russian Doll Limited | Administrative & support | 2019 |
| Russo Trading Limited | Wholesale & retail | 2003 |
| Rutherford Surgical Limited | Health & social care | 2018 |
| RVS Healthcare Limited | Real estate | 2008 |
| RW Cardiology Limited | Health & social care | 2018 |
| RWA FP Ltd | Financial services | 2022 |
| RWM Phillips Consulting Ltd | Information & communication | 2025 |
| Rydal Mews (Management) Limited | Households | 2024 |
| Rylands Properties Limited | Hospitality | 2010 |
| RZ Academy Limited | Education | 2019 |
| S & G Property Solutions Limited | Real estate | 2024 |
| S & G Response Limited | Other services | 2009 |
| S a Kershaw Limited | Health & social care | 2012 |
| S B Rawal Limited | Health & social care | 2010 |
| S Baxter Anaesthetics Limited | Health & social care | 2025 |
| S Bojanic Limited | Health & social care | 2015 |
| S C Chhaya Limited | Health & social care | 2012 |
| S Chatterjee Ltd | Health & social care | 2015 |
| S Clark MAX FAX Surgeon Limited | Health & social care | 2016 |
| S D Corp Limited | Health & social care | 2014 |
| S S Ladha Limited | Health & social care | 2011 |
| S&B Talent Limited | Administrative & support | 2026 |
| S. FOX Engineering Limited | Professional & scientific | 2007 |
| S.Periodontics Ltd | Health & social care | 2013 |
| Sabharata Ltd | Financial services | 2017 |
| Sadact Ltd | Financial services | 2025 |
| Sadie Ozoun Ltd | Other services | 2026 |
| Sadler Properties NW Ltd | Real estate | 2023 |
| Safari Consultancy Ltd | Real estate | 2021 |
| Safdip Limited | Professional & scientific | 2016 |
| Safe Keyping Limited | Extraterritorial | 2007 |
| Safebase Residential Limited | Health & social care | 2025 |
| Safepoint Asbestos Ltd | Water & waste | 2025 |
| Safeskin Surgery Limited | Health & social care | 2020 |