| Re:Volve Property Services Ltd | Real estate | 2021 |
| Reactive Recruit Ltd | Administrative & support | 2014 |
| Ready SET Recycle Ltd | Information & communication | 2018 |
| Readysteadygrow | Administrative & support | 2006 |
| Real Life Studios Ltd | Professional & scientific | 2026 |
| Realties Management Limited | Real estate | 2019 |
| Rectory Court (Marple) RTM Company Limited | Households | 2020 |
| Red Hall Property Limited | Construction | 2003 |
| Red Lantern (Wilmslow) Ltd | Hospitality | 2016 |
| Redcarr Plastering Services Limited | Construction | 2012 |
| Redfern House RTM Company Limited | Households | 2018 |
| Redline Superbikes Limited | Wholesale & retail | 1999 |
| Redmont Investments Ltd | Real estate | 2025 |
| Redstone Health Limited | Health & social care | 2018 |
| Redwood (North-West) Limited | Wholesale & retail | 1991 |
| Redwood House RTM Company Limited | Real estate | 2015 |
| Redwood Rural Advisory Limited | Professional & scientific | 2026 |
| Reech Hospitality Ltd | Hospitality | 2024 |
| Reech Sports Ltd | Arts & recreation | 2017 |
| Reem Construction Limited | Professional & scientific | 2019 |
| Rees Hudson Solicitors Ltd | Professional & scientific | 2024 |
| Refati Ltd | Real estate | 2026 |
| Refine K9 Ltd | Agriculture & fishing | 2025 |
| Refined Reflection Ltd | Other services | 2023 |
| Reflections Manchester Limited | Other services | 2016 |
| Reflex Blue Packaging Ltd | Wholesale & retail | 2007 |
| Reflex Blue Planet Limited | Administrative & support | 2024 |
| Regal Ground Contractors Limited | Construction | 2019 |
| Regen 21 Limited | Construction | 2026 |
| Regents Crescent Management Company Limited | Households | 2010 |
| Reges Holdings Limited | Real estate | 2024 |
| Reggie.Mobi Ltd | Information & communication | 2025 |
| Rehabilitation Case Management Ltd | Health & social care | 2023 |
| Reid Consult Ltd | Professional & scientific | 2025 |
| Rejuvenate Skin Clinic Limited | Health & social care | 2025 |
| Renewable Access Systems Limited | Construction | 2017 |
| Renewed Youth Limited | Health & social care | 2019 |
| Renstar Consulting Ltd | Wholesale & retail | 2015 |
| Rent a Space (Prescot) Ltd | Real estate | 2023 |
| Reproductive Science Consultancy Ltd | Professional & scientific | 2018 |
| Rept Sports Ltd | Administrative & support | 2020 |
| Reset Eco Limited | Professional & scientific | 2020 |
| Residential Compliance Focused Solutions Ltd | Water & waste | 2025 |
| Resilience Medical Communications Ltd | Professional & scientific | 2022 |
| Resilience Netzero Ltd | Energy | 2024 |
| Respect the Game Limited | Education | 2018 |
| Retail Base Limited | Real estate | 2001 |
| Retail Base One Limited | Wholesale & retail | 2019 |
| Revamp Ventures Limited | Real estate | 2014 |
| Reveal Medical Apps Limited | Education | 2020 |
| Reverse Ferret Media Ltd | Professional & scientific | 2023 |
| REX Salut Ltd | Health & social care | 2025 |
| Rexob Limited | Health & social care | 2016 |
| Rexor Technology Limited | Information & communication | 2015 |
| Reyco-Uk Limited | Real estate | 2022 |
| RFM Digital Ltd | Information & communication | 2025 |
| RGB Property Ltd | Real estate | 2019 |
| Rheum 4 Life Ltd | Health & social care | 2018 |
| Rheumatology Consultancy Limited | Health & social care | 2026 |
| RHR Medical Ltd | Health & social care | 2006 |
| Rhythm Care Limited | Health & social care | 2020 |
| Ribblesdale Court RTM Company Limited | Households | 2021 |
| Richard Davenport Limited | Health & social care | 2015 |
| Richard G Johnson Limited | Professional & scientific | 1998 |
| Richardson Group Limited | Professional & scientific | 2008 |
| Richmond Dental Holdings Limited | Health & social care | 2025 |
| Richmond Park Management Company (Hinckley) Limited | Households | 2013 |
| Richwood Securities Limited | Financial services | 1998 |
| Rick Green Cycles Limited | Manufacturing | 2011 |
| Ridgesafe Estates Ltd | Real estate | 2009 |
| Ridgewood Investments Limited | Construction | 2022 |
| Ridings Energy Limited | Professional & scientific | 2023 |
| Rigby Smith Associates Ltd | Professional & scientific | 2012 |
| Rigg END Yorkshire Dales Limited | Hospitality | 2021 |
| Rinard Renovations Limited | Construction | 2021 |
| Ringway Cafe Limited | Transport & logistics | 2026 |
| Ringway Property Ltd | Real estate | 2024 |
| Rinse Dental Hygiene Island Limited | Health & social care | 2024 |
| RISE19 Limited | Hospitality | 2025 |
| Risecafe Wilmslow Ltd | Hospitality | 2022 |
| Rishi Patel Healthcare Limited | Health & social care | 2021 |
| Rishi Patel Property Limited | Real estate | 2022 |
| Risk & Assurance Insights Limited | Professional & scientific | 2011 |
| Ristic Ltd | Real estate | 2022 |
| River Dean Consulting Limited | Information & communication | 2021 |
| Rivers Technology Consulting Ltd | Information & communication | 2023 |
| Riversdale (Wilmslow) Management Company Limited | Households | 2013 |
| Riverside Partners Limited | Health & social care | 2019 |
| Rivington Park (Management Company) Limited | Households | 2024 |
| Rivington View (Management Company) Limited | Households | 2007 |
| RJD Gynae Services Limited | Health & social care | 2017 |
| RJG Accounting Limited | Professional & scientific | 2009 |
| RJG Collective Ltd | Wholesale & retail | 2025 |
| RJO Management Consultants Ltd | Professional & scientific | 2025 |
| RJS Capital Limited | Real estate | 2012 |
| RJS Capital V1 Ltd | Real estate | 2021 |
| RK Linux Systems Limited | Information & communication | 2023 |
| RKR Property LLP | | 2017 |
| RL & a Consulting Limited | Health & social care | 2026 |
| RLJ Medical Limited | Health & social care | 2022 |