| Drivelogic AI Limited | Professional & scientific | 2025 |
| Driven Software Limited | Information & communication | 2023 |
| Drjonnyc Limited | Health & social care | 2023 |
| Drug Safety Solutions Ltd | Professional & scientific | 2002 |
| Drunk Desires Ltd | Wholesale & retail | 2022 |
| DRY Risers Direct Limited | Construction | 2015 |
| Dsah Holdings Limited | Financial services | 2024 |
| DSC Kaizen Ltd | Wholesale & retail | 2023 |
| Dtyl Medical Limited | Health & social care | 2018 |
| Dual Medical Ltd | Health & social care | 2014 |
| DUF Ltd | Administrative & support | 2007 |
| Dugdill Properties Ltd | Real estate | 2025 |
| Dukabora Ltd | Other services | 2025 |
| Dukes Solutions Limited | Administrative & support | 2026 |
| DUNHAM216 Limited | Financial services | 2026 |
| Dunkeld Investments Limited | Financial services | 2025 |
| Dunmill Holdings Limited | Financial services | 2020 |
| Dunsters Construction Limited | Construction | 2017 |
| Durable Fitness Ltd | Arts & recreation | 2015 |
| Duraflon Fabrics Limited | Manufacturing | 2004 |
| Dwcd (UK) Ltd | Information & communication | 2023 |
| Dynamic Wealth Ltd | Financial services | 2024 |
| Dynamis Consultancy Ltd | Professional & scientific | 2019 |
| Dynamis Group Ltd | Professional & scientific | 2021 |
| Dyslexia Sense Limited | Education | 2023 |
| E E B Consulting Ltd | Professional & scientific | 2024 |
| E Grace Motors Ltd | Wholesale & retail | 2026 |
| E Quip Camping for Less Ltd | Wholesale & retail | 2015 |
| E&I Living Limited | Real estate | 2025 |
| E.C.C. Consulting Limited | Administrative & support | 2015 |
| E.G. Financial Planning Ltd | Professional & scientific | 2025 |
| E2E Limited | Professional & scientific | 2017 |
| E5 Growth Advisory Group Ltd | Professional & scientific | 2023 |
| Eagles Wilmslow FC Ltd | Education | 2026 |
| Eagles Wing Healthcare Solutions Ltd | Health & social care | 2022 |
| Eaglethorn Estates Ltd | Real estate | 2008 |
| Eales Medical Limited | Health & social care | 2010 |
| EAM Lodge Community Interest Company | Administrative & support | 2009 |
| Eardley Property Services Limited | Real estate | 2025 |
| Earl Digital Ltd | Professional & scientific | 2018 |
| Earle Gardens (Dunchurch) Management Company Limited | Households | 2017 |
| Ears and Noses Ltd | Health & social care | 2023 |
| Earthlabs Ltd. | Professional & scientific | 2016 |
| East Cheshire Cardiology Limited | Health & social care | 2019 |
| East Lawn Limited | Real estate | 2000 |
| East Midlands Aggregates Ltd | Mining & quarrying | 2022 |
| East Park Medical Limited | Health & social care | 2023 |
| Easy 2 LET Properties Limited | Real estate | 2019 |
| Easy Way Properties Ltd | Real estate | 2023 |
| EASY2LET Manchester Limited | Real estate | 2014 |
| Easyqbuy Ltd | Wholesale & retail | 2025 |
| Eaton Court Holly Road North Freehold Company Limited | Households | 2021 |
| Eaves Communications Limited | Professional & scientific | 2013 |
| EBB3 Limited | Information & communication | 2016 |
| Ebro Assets Limited | Real estate | 2019 |
| Echo Media Ltd | Professional & scientific | 2021 |
| Ecig World Ltd | Wholesale & retail | 2015 |
| Ecjb Investments Limited | Professional & scientific | 2025 |
| Eckley Financial Strategies Limited | Financial services | 2016 |
| Ecobubl Ltd | Construction | 2020 |
| Ecom Eilya Ltd | Information & communication | 2020 |
| Ecosphere Development Limited | Other services | 2024 |
| Ecosphere Group Limited | Financial services | 2024 |
| Ecosphere Limited | Administrative & support | 2016 |
| Ecosphere PV Limited | Other services | 2024 |
| Ecosphere SPV Limited | Other services | 2024 |
| EDB2 Ltd | Professional & scientific | 2026 |
| Eden Point Limited | Professional & scientific | 2006 |
| Eden Residences Ltd | Real estate | 2021 |
| Edenbrook Property Services Ltd | Construction | 2022 |
| EDG Wilson Surgery Ltd | Health & social care | 2019 |
| Edge 360 Fitness Ltd | Arts & recreation | 2017 |
| Edge Decorating Ltd | Construction | 2026 |
| Edge Fencing Ltd | Administrative & support | 2018 |
| Edge Holdings NW Ltd | Construction | 2024 |
| Edge Management Solutions Ltd | Construction | 2013 |
| Edge Osteopathy Ltd | Health & social care | 2021 |
| Edgeway Services Limited | Professional & scientific | 2021 |
| Edit Consultants Ltd | Professional & scientific | 2016 |
| Edmunds Architects Limited | Professional & scientific | 2020 |
| EDS Resources Limited | Professional & scientific | 2014 |
| EDT UK Limited | Construction | 2017 |
| Education Rentals Limited | Financial services | 2017 |
| Edulease Limited | Other services | 2009 |
| Edward Jeans Limited | Health & social care | 2023 |
| EEA Property Limited | Real estate | 2017 |
| EF Coaching & Consulting Ltd | Professional & scientific | 2024 |
| EF EXP Ltd | Administrative & support | 2017 |
| Egcc Group Limited | Real estate | 2019 |
| Egerton Park (Altrincham) Management Company Limited | Households | 2016 |
| Egnimed Limited | Health & social care | 2025 |
| EHC Moston Grange Limited | Health & social care | 1998 |
| EHC Oakland House Limited | Health & social care | 2006 |
| EHC Pathways Limited | Health & social care | 2005 |
| Eigentum Group Ltd | Financial services | 2022 |
| EJ Consulting Limited | Professional & scientific | 2006 |
| EJL Hunt Ltd | Health & social care | 2023 |
| Ejpw Limited | Professional & scientific | 2020 |
| EJS Cardiology Limited | Health & social care | 2026 |
| Ekinox Ltd | Wholesale & retail | 2023 |